Ardineclav 500/125 laboratorio Reig JOFRE drinking powder for short -term infections (12 packs)

Dosage form 12 package box
Specifications Clavulanic acid, amoxicilin
Ingredient Laboratorio Reig Jofre

Ingredient

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Composition information	Content
Clavulanic acid	125mg
Amoxicilin	500mg

Uses

Indications

Ardineclav 500mg/125mg oral powder for short-term treatment of sensitive bacterial infections in the following positions, when possible caused by amoxicillin resistant strains.

Upper respiratory tract infections (including ear, nose and throat infections), especially sinusitis, otitis media, recurrent tonsillitis. Bacteria, obstetric infections and abdominal infections. Concomitant use with Clavulanic Acid does not change the mechanism of action of amoxicillin. However, because Clavulanic Acid has high affinity and links with some beta-lactamase yeasts that these yeast often lose the activity of amoxicillin due to hydrolysis of beta-lactam loop, simultaneous use of clavulanic acid with amoxicillin as a co-effect of antibacterial effect, thereby expanding the antibacterial spectrum of amoxicilin for many strains of lactamase antibacterial bacteria when using poisonous.

Clavulanic Acid often works as a competitive, reversible beta-lactamase inhibitor, clavulanic acid has a structure similar to penicillin and cephalospolin, starting it acts as a competitive inhibitor and binding at the operating position on beta-lactamase. Then form an acyl that is not active but only has no temporary activity because this intermediate can be hydrolyzed, resulting in restoring the activity of beta-lactamase and releasing the degenerative products of Clavulanic Acid.

Gram -positive aerobic bacteria:

Staphylococcus aureus (including penicillinase strains). pyogenes.

Gram -negative aerobic bacteria:

Escherichia coli. Both penicillinase strains).

Proteus mirabilis. After drinking, both active ingredients reach the peak concentration of about 1 hour and this concentration is directly related to the dose. Absorption is not affected when used with food, milk ... and binding to protein is 22% in in vitro test.

both clavulanic acid and amoxicillin have an average 1 -hour disposal time on healthy volunteers. The main elimination road is the urinary tract.

Before taking Ardineclav 500/125 laboratorio Reig JOFRE drinking powder for short -term infections (12 packs)

How to use

Should drink ARDINECCLAV 500mg/125mg oral powder at the beginning of the meal to reduce intolerance. Treatment time is appropriate with indications and should not exceed 14 days if not consult the doctor again.

Dosage

Adults and children over 40 kg: Indications to use ArdineClay 500/125 to treat severe infections in adults: 1 pack at each time, 3 times daily.

Dosage when kidney failure:

mild renal failure (Creatinin clearance> 30 ml/min): No change of dose. Now.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Also encountered rash, hyperactive, or drowsy in a few patients.

In case of overdose, stop amoxicillin clavulanate, symptomatic treatment, and use support measures, if necessary. If an overdose occurs, and there is no contraindication, trying to cause vomiting or use other measures to eliminate the smoking from the stomach.

Both Amoxicilin and Clavulanat can be removed from circulation by hemorrhage.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

With normal doses, unwanted effects show over 5% of patients, most common are digestive reactions: diarrhea, nausea, vomiting. This reaction ratio increases when the dose is higher and more common than the amoxicillin.

Common, ADR> 1/100

Digestive: diarrhea.

Blood: hyperlypes Can be heavy and last for a few months.

Systemic body: Anaphylaxis reaction, Phuincke. Interstitial.

Instructions on how to handle ADR

When there is a serious anaphylactic reaction, it should be processed immediately by epinephrin, oxygen, intravenous corticosteroids.

Transaminase increases: Clinical significance is unknown. Attention should be paid to the elderly and adults, preventing the detection of cholestatic hepatitis.

Radio, erythema, Stevens syndrome - Johnson, Bong dermatitis: Must stop the drug.

fake colitis:

If light: Stop drugs.

If heavy (possibilities due to Clostridium difficile): Water and electrolyte, anti -Clostridium antibiotic.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ARDINECLAV 500mg/125mg oral powder is contraindicated in the following cases:

Patients with hypersensitivity to penicillin. Pay attention to the ability to hypersensitize with other beta-lactam antibiotics, for example, cephalosporins.

Be cautious when using

Hypersensitivity reactions and sometimes fatal (anaphylaxis) occurred in patients using penicillin. These reactions are more likely to occur in people with a history of hypersensitivity to penicillin.

has seen changes in liver function tests in some patients using amoxicillin/ clavulanic acid. The clinical significance of these changes is not sure but carefully using amoxicillin/ clavulanic acid in patients with evidence of liver function failure.

Rare jaundice can be heavy but often recovered. Signs and symptoms may end after a few weeks of stopping treatment.

Fake colitis has met with most antibiotics, including amoxicillin/ clavulanic acid, from mild to life -threatening. Therefore, it is important to pay attention to this diagnosis in patients with diarrhea after antibiotics. To reduce the expansion of anti -drug bacteria and maintain the effect of ArdineClay as well as other antibiotics, only use ArdineClay to treat or prevent infections that have known or more likely to be caused by sensitive bacteria. When information about culture and sensitivity, should be used to choose or adjust the treatment regimen with antibiotics.

The risk of convulsions when taking high doses or in patients with renal failure.

The risk of general development.

Caution for patients with redness with lymphadenopathy.

The effect of the drug on the ability to drive and operate machinery

unknown effects of the drug.

Use drugs for women during pregnancy and lactation

Pregnant women:

Studies on animal reproduction (mice and large mice) with oral and injections of amoxicillin/ clavulanic acid have shown that there is no teratogenic effect. Experience in using amoxicillin/ clavulanic acid in pregnant people is limited. Like all other drugs, should be avoided during pregnancy, especially in the first three months unless the physician is really necessary.

breastfeeding women:

Ampicillin antibiotics secretize human milk, so be careful when using ArdineClay for breastfeeding.

Drug interaction

Probenecid reduces excretion in the renal tubules of amoxicillin. Concentrated use with probenecid causes increased and prolonged blood concentration of blood amoxicillin.

Extended bleeding time and prothrombin time in some patients using amoxicillin/clavulanic acid. Be careful to use amoxicillin/clavulanic acid for patients who are under coagulation treatment. Like other broad -spectrum antibiotics, amoxicillin/clavulanic acid can reduce the effectiveness of oral contraceptives, so patients need to be warned. Using allopurinol while using amoxicillin may increase skin allergic reactions. There is no data on simultaneous use of amoxicillin/clavulanic acid and allopurinol.

Storage

Store in a cool dry place, temperatures below 30 degrees Celsius, avoiding light.

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