Arenmax tab Yooyoung room and osteoporosis treatment (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Alendronic Acid
Ingredient Osteoporosis, osteoporosis in South, fracture

Ingredient

Composition information	Content
Alendronic Acid	70mg

Uses

indications

Arenmax tab drugs are indicated in the following case:

Treatment and prevent osteoporosis in menopausal women. In the treatment of osteoporosis, alendronat increases bone mass and prevents fractures, including hip, wrist and vertebra (broken vertebrae). Pre -clinical studies show that Alendronat accumulates selectively at the active bone pepper position, where Alendronat inhibits the operation of the cell cancel.

Clinical studies show that Alendronat treatment can significantly increase the volume of bone in the spine, femur and transfer. In clinical studies in menopausal women from 40 to 85 years old with osteoporosis (determined to have low bone mass, at least two standard deviations below the average of the before menopause), Alendronat treatment significantly reduces the number of spine fractures after 3 years of medication.

The density of bone minerals increases clearly after 3 months of Alendronat treatment and continues during the use of the drug. However, after 1-2 years of treatment, if the alendronat is stopped, it does not maintain an increase in bone mass. This proves to be constantly treated daily to maintain the healing effect.

pharmacokinetic

absorption

Average oral use in women is 0.7% with doses in the range of 5 - 40mg, taken after 1 fast fast and 2 hours before a standard breakfast.

Distribution

Alendronat (Alendronic Acid) is transiently distributed in soft tissues but then redistributed to the bone and exit through the urine. Links to protein in human plasma is approximately 78%.

Metabolism

There is no evidence that alendronat is metabolized in humans.

Elimination

The renal clearance of the alendronat is 71ml/min. The sale time of the drug is estimated to exceed 10 years, perhaps reflecting the release of Alendronat from the skeleton.

Before taking Arenmax tab Yooyoung room and osteoporosis treatment (1 blister x 4 tablets)

How to use

Do not chew or suck the pill. Do not lie within at least 30 minutes after the drug and until the first meal of the day.

Dosage

Take 1 tablet at a single time, 1 time of the week (7 days), must drink with 1 cup of water full of normal water at the time of waking up during the day and at least 30 minutes before eating, drinking or taking other drugs.

Take it on the same day.

Elderly

No need to adjust the dose.

Patients with renal failure

Creatinine Clcr> 35ml/minute: No dose adjustment.

Creatinin Clcr clearance

Children under 18 years old

Not used due to insufficient research on efficiency and safety.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Hydropic calcium reduction, hype phosphate and unwanted reactions in the gastrointestinal tract such as gastrointestinal disorders in the stomach, heartburn, esophagitis, inflammation or stomach ulcer may be due to overdose of Alendronat.

Should use milk and antacid agents to link alendronat. Due to the risk of esophageal irritation, do not cause vomiting and patients still have to sit upright. The separation is not effective.

What to do when forgetting a dose? Do not take two capsules at the same time but continue to take one capsules per week on the original selected day.

Side Effects

When using Arenmax Tab, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: weakness, peripheralema.

Central nervous system: headache, dizziness. digestive: abdominal pain, flatulence, acid reflux, esophageal ulcer, difficulty swallowing, bloating, indigestion, constipation, diarrhea.

musculoskeletal: musculoskeletal pain.

Skin and tissue disorders: itching, hair loss.

Uncommon, 1/1000

DA: Ban, Red Ban.

digestive: gastritis (0.5%), disturbance, nausea, vomiting.

Eyes: Eye inflammation (Ivanitis, Eye Harditis, Eythogue).

Rare, ADR

DA: Alendronat allergies in particular and bisphosphonate in general such as urticaria, angioedema, Steven - Johnson syndrome and poisonous epidermal necrosis.

Ear, eye: Hearing virtual, visual disorders, external ear necrosis.

musculoskeletal joints: Jaw necrosis, jaw joint damage, thigh bone fractures may be broken when used for prolonged medication.

Immune system: reducing blood calcium.

digestive: esophagus stenosis, pharyngeal ulcer, complications on the gastrointestinal tract (bleeding, ulcers, perforation).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Arenmax tab drugs in the following cases:

esophagus deformities slow the esophagus, for example, narrow or non -relaxing esophagus. Inability to stand or sit upright for at least 30 minutes.

Precautions when used

There have been reports on events in esophagus, esophagitis, esophagitis, esophagus, sometimes with bleeding, in patients who are treating alendronat. Therefore, the patient must be instructed to stop Alendronat and see a physician if it is difficult to swallow, swallow pain or pain behind the breastbone.

Be careful when using alendronat in patients with pathology is active in the gastrointestinal tract (for example, difficulty swallowing, esophagus, gastritis, duodenum or ulcer).

Must treat blood calcium loss before starting with Alendronat treatment. As well as effectively treating other disorders of inorganic metabolism (for example, vitamin D deficiency).

Must guide patients with calcium and vitamin D supplements, if the daily amount in the diet is not enough.

Jaw bone necrosis, often associated with tooth extraction or local infection (including osteomalitis), has been reported in cancer patients when in the treatment regimen combining bishosphonate drugs that are passed by intravenously. There has been a report of jaw bone necrosis in patients with osteoporosis when treated with oral bisphosphonates.

The following risk factors should be considered when evaluating the ability to necrosis of the jaw bone when the patient uses bisphosphonate:

Effect of bisphosphonate, sugar and accumulated doses in cancer patients.

Risk factors simultaneously include cancer, chemotherapy, radiation, corticosteroid, tobacco.

History of dental disease including poor hygiene, periodontal disease, tooth trauma ...

Before treatment with bisphosphonates patients should be checked for dental regularly and during treatment should not perform any tricks related to dental. During the treatment of bisphosphonate, all patients need to be recommended to maintain good oral hygiene, regularly check teeth and report any dental symptoms such as pain, swelling or toothache.

External ear necrosis has been reported when long -term bisphosphonate treatment. The risk factor for increased external ear necrosis includes steroid and chemotherapy or local risk factors such as infection or injury. For patients with ear disease such as chronic ear infections, it is necessary to consider and evaluate when treated with bisphosphonat.

musculoskeletal pain: There is a report in patients when taking prolonged bisphosphonate. This symptom is usually not severe and decreases. Most patients reduce this symptom after stopping the drug.

Fracture: There has been reports of femur fractures in patients when using long -term bisphosphonate for osteoporosis. The likelihood of the femur often occurs in the thighs, so the opposite thigh should be checked if there is a thigh fracture on one side. Stop using bisphosphonate if the benefits and risks have been assessed in patients with femur fractures. During the treatment process, it is necessary to monitor and notify any symptoms related to bone and joints.

During the drug circulation, there was a report (very rare) serious reaction on the skin such as Steven - Johnson syndrome and poisonous epidermal necrosis.

There is no recommendation when patients with renal failure have a clearance coefficient

The drug contains lactose, so it is necessary to be cautious in patients without lactose intolerance.

The ability to drive and operate machinery

The drug can cause headaches so be cautious when used for drivers and machinery operation.

Pregnancy

through effects on lip balca balance and bone metabolism, alendronate can cause harm to the fetus or for newborn babies. It has been found to be difficult to produce and formulate bones in animal studies, so it is not allowed to use Alendronat during pregnancy.

Breastfeeding period

It is unknown whether Alendronat will be exported to breast milk or not. So be cautious when using Alendronat for women who are breastfeeding.

Drug interaction

estrogen: Safe and effective of simultaneous use of hormone replacement therapy and alendronat for postmenopausal women have not been determined, so it is not recommended this simultaneous usage.

Calcium supplements and anti -acid drugs: can reduce the absorption of alendronat. Therefore, the patient must wait at least half an hour after taking Alendronat to use any other drug.

Non -steroid anti -inflammatory drugs (NSAID): NSAID drugs often cause gastrointestinal irritation, so they must be cautious when used with Alendronat.

Storage

Store in a dry place, avoid light, temperatures below 30 ° C.

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