Argistad 1g Stella oral solution for hyper ammonia (20 tubes x 5ml)

Dosage form Box of 20 tubes x 5ml
Specifications Arginin hydrochlorid
Ingredient ArgininoSuccinic acid, hyper ammonia blood, URE cycle disorders

Ingredient

Thành phần cho 5ml

Composition informationContent
Arginin hydrochlorid1000mg

Uses

Indication

Argistad is indicated in case of:

  • Treatment of hyperconemia in patients with carbamoylphosphate synthetase, lack of ornithin transcarbamylase. Practicing skills in people with stable cardiovascular disease. In the urea cycle for patients who lack enzymes: N - Acetylglutamate Synthase (NAGS), Carbamoylphosphate Synthetase (CPS), Ornithin Transiscarbamylase (OTC), ArgininoSuccinat Synthetase (ASSS), or ArginininoSuccinat Lyase (ASL). Use Arginine hydrochloride for patients with disorders as above to restore arginine concentrations in the blood and help prevent protein catabolism. The intermediate products of the urea cycle are less toxic and easily eliminate through urine than ammonia and create other paths for excess nitrogen elimination.

    arginine increases blood glucose levels. This effect may be direct effect; The amount of glucose released from the liver is directly associated with the amount of amino acids absorbed. The Glycogen prize and the new glucose creation may also be the intermediary of the arginine process that stimulates the liberation of Glucagon.

    Pharmacokinetics

    absorption

    Arginine Hydrochloride absorbs well through the digestive tract, the peak of plasma peaks is achieved after about 2 hours.

    Metabolism

    Arginine Hydrochloride is closely combined with many biochemical paths. Amino acids are metabolized through the liver to form ornithin and urea by hydrating guanidine under the catalyst of Arginase.

    Elimination

    arginine is filtered in glomerular and reabsorbed almost entirely in the renal tubules.

    • Before taking Argistad 1g Stella oral solution for hyper ammonia (20 tubes x 5ml)

    How to use

    argistad 1 g is used by oral.

    Dosage

    Maintenance of hyperconemic ammonia in patients with carbamoylphosphate synthetase, ornithin transcarbamylase

    Babies and babies aged 1 - 18 months: 0.5 ml/kg per day, divided 3-4 times.

    Maintenance treatment for patients with hyperiemia, blood citrulin, argininosuccinicuria

    Babies and babies from 1 - 18 months of age: 0.5 - 0.875 ml/kg/time, use 3-4 times daily with food, adjust the dose according to response.

    Treatment support indigestion

    Adults: 15 - 30 ml/day.

    Supporting treatment to improve exercise ability in people with stable cardiovascular disease

    Adults: 30 - 105 ml/day, each use no more than 40 ml.

    Nutrition supplements for people with urea cycle disorders such as hyper ammonia hyper type I and II, blood citrulin, ArgininoSuccinicuria and N-acetylglutamate Synthase

    deficiency

    Adults: 15 - 100 ml/day depending on the condition.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Acid infection will be neutralized and the deficiency of bases will return to normal after infusion. If the condition is still, it is advisable to determine the degree of deficiency and adjust by calculating the amount of alkaline agent.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using 1 g argistad, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • No report.

    • Uncommon, 1/1000

  • No report.

    • Not determined frequency

  • Metabolism: Bun, creatinin and serum creatin.
    • digestion: pain and abdominal distention. blood vessels: Increase the purple blue. blood and lymphatic system: thrombocytopenia, sickle cell anemia. The immune system: allergic reactions to manifestations such as red rash, hand swelling and face.

    Instructions on how to handle ADR

    Allergic reactions will decrease rapidly when stopping the drug and using extra diphendramin.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    ARGISTAD 1 g drug is contraindicated in the following cases:

  • Patients with hypersensitivity to any ingredients of the drug.
  • Patients with allergies.
  • Patients with Urian cycle disorders with Arginase deficiency.

    • Be cautious when using

    Pay attention to the sugar content of the drug (2 g in every 5 ml) when used for patients with diabetes or sugar -diet patients.

    Should stop the drug if diarrhea occurs.

    Arginine may change the ratio between extracellular and intracellular potassium, plasma potassium levels may increase when using arginine in patients with renal impairment. Should be cautious when taking Arginine for patients with kidney disease or urinating.

    When using high doses of arginine to treat acute hyperactive hyperglycemia can cause metabolic acidic contamination due to hypercasses; Therefore, chloride and plasma bicarbonate levels should be monitored and at the same time adding the corresponding amount of bicarbonate.

    Arginine contains a high metabolic nitrogen content, so it should evaluate the temporary impact of high nitrogen on the kidneys before starting treatment with arginine. Arginine does not have the effect of treating hyperactive hyperactive hyperacture caused by organic acid disorders, and should not be used in case of disorder.

    Argistad 1 g contains sucrose (white sugar). This medication should not be used for patients with rare genetic problems that are fructose intolerance, Glucose - Galactose or SUCRASE - Isomaltase.

    Argistad 1 g contains methylparaben and propylparaben, which can cause allergic reactions (occurring late).

    The ability to drive and operate machinery

    No report.

    Pregnancy

    Studies on reproduction have been conducted on rabbits and mice at 12 times higher dose for humans and do not see any manifestations of fertility decline or damage to arginine fetuses.

    There is no complete and controlled research on pregnant women. Because animal reproductive studies are not always forecasted to be met in humans, therefore, drugs should not be used during pregnancy.

    breastfeeding period

    amino acids are excreted into breast milk in very small amounts that can not be harmful to children. However, caution should be cautious when taking medicine in nursing women.

    Drug interaction

    Insulin concentration in plasma due to arginine stimulation may increase higher by thiazid, xylitol and aminophyllin diuretics.

    Using oral diabetes treatment drugs for long periods of time can inhibit plasma glucagon response to arginine. When patients who do not tolerate glucose are used for glucose, phenytoin reduces insulin response in plasma with arginine. Hyperbonemia may occur when using Arginine to treat metabolic alkaline infections for patients with new severe liver disease using spironolacton recently.

    Storage

    Store in closed packaging, avoiding light. The temperature does not exceed 30 ° C.

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