Armten 90 Armephaco oral media treat acute respiratory infections (10 packs x 1.5g)

Dosage form 10 package box
Specifications Ceftibuten
Ingredient Branch of Armephaco Joint Stock Company- Pharmaceutical Enterprise 150

Ingredient

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Composition information	Content
Ceftibuten	90mg

Uses

Indications

ceftibuten are indicated for treatment of medium and mild infections caused by sensitive bacteria, such as:

Respiratory infections: Acute attacks in chronic bronchitis, upper jaw sinusitis, acute bronchitis, Haemophilus influenzae, Moraxella Catatrhalis or Streptococcus pneumoniae. Streptococcus pyogenes. Area

Pharmacological group: antibiotics of Cephalosporin group 3

ATC code: J01DD14

Mechanism of action:

Ceftibuten is semi -synthetic cephalosporin antibiotic, 3rd generation, with bactericidal effects. CEFTIBUTEN inhibits the synthesis of bacterial cell walls. CEFTIBUTEN is sustainable with beta-lactamase enzymes, so the drug is effective for many resistance strains with penicillin or some other antibiotics belonging to the cephalosporin group.

CEFTIBUTEN is highly sustainable with penicillinase and cephalosporinase through plasmid intermediaries, not durable with some cephalosporinase through intermediaries in bacteria such as Citrobacter, Enterobacter and Bacteroides.

ceftibuten has been shown in vitro and clinically, showing the drug works on most of the following bacteria:

Gram -positive bacteria:

Streptococcus pyogenes, Streptococcus pneumoniae (except for penicillin resistance lines).

Gram -negative bacteria:

Haemophilus Influenzae (Beta Lactamase positive and negative). Calculate).

Escherichia Coli; Klebsiella sp. (including K. Pneumoniae and K. Oxytoca). P. Mirabilis. Salmonella SP; Shigella sp.

Gram -positive bacteria:

Streptocbecus group C and group G.

Gram -negative bacteria:

Brucella, Neiserria, Aeromonas Hydrophilia, Yersinia Enterocotilica, Providencia Rettgeri,

Providencia Stuartii and Citrobacter, Morganella and Serratia series are not multi -secreting Cephalosporinase through chromosomes.

ceftibuten has no activity on Staphylococcus, Enterococcus, Acinetobacter, Listeria, Flavobacteria and Pseudomonas spp.

Medicinal resistance mechanism:

CEFTIBUTEN is unstable with some cephalosporinase through chromosomes in bacteria such as Bacteroides, Citrobacter, Enerobacter, Morganella and Serratia.

Like other beta-lactam, CEFTIBUTEN should not be used against beta-lactam resistance strains due to common mechanisms such as changing membrane absorption or penicillin-mounted protein-mounted protein like S. Pneumoniae penicillin.

Dynamic pharmacokinetics

CEFTIBUTEN is quickly absorbed through the digestive system after oral, oral use of the drug is about 75-90%. Food reduces the speed and level of absorption of CEFTIBUTEN, but this impact mainly affects the bioavailability of CEFTIBUTEN when used in the form of more fluid, less affected when used in the form of capsules.

After taking a dose of 400 mg/time/day, CEFTIBUTEN is capsule in 7 days, the average peak concentration of 17.9 mcg/ml on the 7th day. The distribution is about 0.21 l/kg in healthy adults and about 0.5 l/kg in children. After drinking, Ceftibuten distributes into the fluid in the burning place, pulmonary fluid, nasal secretion, saliva, middle ear secretion, tracheal secretion, tonsils. About 65% of drugs are linked to plasma proteins.

Selling plasma waste time of an average of 2-2.4 hours in healthy adults with normal kidney function and 1.9-2.5 hours in children 6 months to 16 years old.

CEFTIBUTEN is present in plasma and urine mainly in the form of cis -cebuten. About 10% converts into Trans-Socftibuten. Trans isomers are lower, only about 12% compared to CIS isomers. Selling plasma waste time is longer in patients with renal failure.

The drug is mainly eliminated through urine. After taking the dose of 400 mg (researching in healthy men), about 57-70% of the dosage excreted through urine in the form of unchanged and about 7-20% is excreted in the form of CIS isomers.

ceftibuten through hemolysis membrane.

Before taking Armten 90 Armephaco oral media treat acute respiratory infections (10 packs x 1.5g)

How to use

Mixed powder mixed in water for oral fluid.

Dosage

is like other oral antibiotics, the general treatment time is 5-10 days.

Children 6 months to 12 years: recommended dose is 9 mg/kg/day (maximum 400 mg per day) in the form of oral fluid. It is possible to use once a day in the treatment of the following indications: sore throat, whether or not there is tonsillitis, acute otitis media with pus and urinary tract infections with or without complications.

What to do when overdose?

Treatment:

Can appoint stomach, hemolysis. There is no specific detoxification. The effectiveness of removing the body has not been determined by peritoneal fertilizer.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The adverse reaction is classified by the following frequency: Very common (≥1/10); Common (1/100 to

Side effects may be encountered when using ceftibuten including:

System of agencies Common rarely rarely Cephalosporin's antibiotic report reports: superinfection

Eat

Children: agitation, insomnia, discomfort, chills.

epilepsy

mental disorders, language disorders Disorders of taste, gastritis, vomiting, abdominal pain, constipation, dry mouth

Cephalosporin antibiotic report: fake colitis

liver disorders

Children: diaper rash

Children: blood

Cephalosporin's antibiotic report report: Kidney, kidney dysfunction, bilirubin, directly positive coombs test, urinary keton ALT

From clinical trials, most patients stop drugs when disorders on the gastrointestinal tract, usually diarrhea or vomiting.

Some cephalosporin have been reported to activate seizures, especially in patients with impaired renal function not to be adjusted. If a seizure occurs, stop the drug, may prescribe anti -epileptic drugs if the clinical condition is required.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Do not use for patients with allergies or hypersensitivity to antibiotics of cephalosporin group and any ingredient of the drug.

Be cautious when using

Prisable to use in patients allergic to penicillin.

If in the process of using the drug, in patients with sensitive reactions, the drug must be discontinued immediately and use appropriate treatments (such as epinephrin, corticosteroids, and maintain ventilation for patients).

Precautions to monitor patients using long spectrum antibiotics, due to excessive development of non -sensitive strains.

Should reduce the dose in patients with renal failure.

has not determined the safety and effectiveness in children under 6 months of age.

Excipients: The drug contains sucrose, so it is necessary to be cautious with diabetics and patients with rare genetic problems in non-tolerance of fructose, poorly absorbing glucose-galactose or deficiency of sucrase-isomaltase should not use this drug.

The effect of the drug on the ability to drive and operate machinery

Patients who experience unwanted effects such as nausea, vomiting should be cautious when driving or operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

Only for pregnant women, in the opinion of the doctor, the benefits of treatment for the mother greater than the potential risks for the fetus.

breastfeeding women

There is no document about the ability to secret out of Ceftibuten's breast milk, so it is only used when it is necessary.

Medicinal interaction

The use of oral ketotifen can increase the effects of central neurological inhibitors, antihistamines and alcohol.

Storage

Storage in closed packaging, avoid moisture, light, at temperatures below 30 ° C.

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