Artrodar 50mg chemedica treatment of hip or knee degeneration (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Diacerein
Ingredient Trb Pharma S.A

Ingredient

Composition information	Content
Diacerein	50mg

Uses

Indications

Artrodar 50 drugs are indicated in case of treatment of hip or knee degeneration symptoms, with slow effects.

Do not recommend the treatment of hip degeneration has progressed rapidly because it can be weakened with diacerein.

Pharmacokology

Diacerein is an anti -osteoarthritis drug that has anti -inflammatory effects to treat osteoarthritis (osteoarthritis and related diseases), well tolerated in the stomach because the drug does not inhibit the propaglandin synthesis.

Diacerein is likely to affect both assimilation and catabolism of cartilage cells and reduce inflammatory factors. The results of some studies In-Vitro and In-Vivo showed that Diacerein and Rhein, a metabolic substance with its activity, inhibit the production and activity of Cytokine Il-LB of inflammatory and pre-catabolic, both in the shallow and deep layer of cartilage, in the epidemic membrane and the epidemic membrane while stimulating the production factor of the formation of the formation of the form of the Basic substance in the formation Proteoglycan, Aggrecan, Hyaluronic Acid and Type II glue.

In addition, these substances also show inhibition of macrophages and movement of macrophages. Studies in some animal osteoarthritis models show that diacerein reduces cartilage degeneration compared to untreated groups.

pharmacokinetic

absorption

After using a single dose of 50 mg of diacerein, the peak plasma concentration is achieved after 2.5 hours, cmax is about 3 mg/l. The pharmacokinetics parameters do not depend on the dose when using Diacerein dose in the range of 50 mg - 200 mg. Used with food increases 25% of the absorption capacity. Therefore, should share diacerein with food.

Distribution

Rhein (metabolites with Diacerein activity) connect 99% with plasma albumin, a smaller amount associated with lipoprotein and immunoglobulin gamma. The epidemic concentration reaches 0.3 to 3.0 mg/l.

Metabolism

Diacerein is strongly metabolized (100%) in the liver after oral, diacerein will be reduced to acetyl to form an active metabolic substance.

Elimination

Diacerein is excreted through urine in the form of metabolism in the range of 35% - 60%, of which about 20% in the form of free Rhein and 80% are compounds of Rhein.

After taking the dose of the Diacerein hard capsule (50mg x 2 times/day), there is a slight accumulation. In patients with severe renal failure (creatinine clearance below 30 ml/minute), the area under the curve and the half -life of cancellation increased and eliminated through the urine by half.

Before taking Artrodar 50mg chemedica treatment of hip or knee degeneration (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

The use of diacerein should be started by a doctor who has experience in treating osteoarthritis.

Because some patients may have loose or diarrhea, Diacerein's recommended starting dose is 50 mg once a day for dinner for the first 2-4 weeks. It may be increased by 50 mg 2 times/day. At that time, you should take medicine with meals (one pill at breakfast and the other for dinner). The drug must be swallowed intact (do not break the drug) with 1 glass of water.

The doctor will determine the time to take the drug depending on the results of treatment. However, do not stop the drug before 6 months.

Due to the slow onset of acting (after 2-4 weeks of treatment), Diacerein can be combined with an anti -inflammatory drug that is not in the steroid group or analgesics for the first 2-4 weeks of treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Need to treat symptoms and restore water - electrolytes if necessary.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Artrodar 50, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Gastrointestinal disorders: diarrhea, abdominal pain. Increase intestinal motility, flatulence. These effects will be relieved when continuing to use the drug. In some cases, serious diarrhea has complications such as dehydration and electrolyte weight disorders.

Liver disorders: Increased serum liver enzyme. This is a typical sign of the compound in the drug and has no clinical significance.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Angorar 50 anti -contraindications in the following cases:

Known hypersensitivity to the drug or excipients of the drug.

History of hypersensitivity to anthraquinone derivative.

is expensive or a history of liver disease.

History of severe diarrhea, dehydration, and hypotension to be hospitalized.

Consider the benefits/risk of using artrodar for patients with previous intestinal disorders, especially the colon is easily stimulated.

Caution when using

Renal failure (Creatinine clearance

Diacerein should not be prescribed for children under 15 years old because there is no clinical research that has been conducted at this age.

diarrhea:

Diacerein regularly can cause diarrhea, thereby leading to tears and hypokalemia. Patients should stop using when diarrhea and discuss with the doctor for treatment of alternative treatments.

Be cautious when using diacerein for patients who use diuretics due to increased risk of dehydration and hypokalemia. Especially cautious to prevent hypotension in patients using the cardiac glycosides (Digitoxin, Digoxin).

Avoid simultaneous use of diacerein with laxatives.

Liver poisoning:

Increased serum liver enzyme levels and acute liver damage symptoms were recorded during the circulation of diacerein in the market.

Before starting treatment with diacerein, the patient should be asked for attached and history diseases, especially liver diseases and screening the main causes of progressive liver disease. If diagnosis of liver disease is identified, contraindicated using diacerein.

Need to closely monitor the signs of liver damage and caution when using diacerein simultaneously with drugs that can cause liver damage. Recommend patients to reduce alcohol while being treated with diacerein.

Stop using diacerein if the liver enzyme is detected or suspected to show signs and symptoms of liver toxicity and ask the patient to immediately contact the treating doctor in the event of a sign of liver damage.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Animal studies show that bone mineralization makes the fetal growth due to toxic effects on mothers in high doses. There is no complete research data in clinically to assess the possibility of monitoring or toxic to the fetal of diacerein during pregnancy. Therefore, do not recommend diacerein during pregnancy.

Breastfeeding period

Do not use diacerein for women who are breastfeeding because there is a report that shows small amounts of anthraquinon derivatives into breast milk.

Drug interaction

should avoid simultaneous use with salt, oxide or aluminum hydroxide, calcium and magnesium hydroxide because they reduce diacerein absorption. Diacerein should be used at least 2 hours away from these drugs.

Using diacerein can cause diarrhea and hypotension. Caution should be used with simultaneous use with diuretics (diuretics and thiazids) or with cardiac glycosides (digitoxin, digoxin) due to increased risk of arrhythmia.

Storage

Store at room temperature (15 ° C).

Expiry date: 36 months from the date of production.

Do not use overdue drugs indicated on the packaging.

Manufacturer: Trb Pharma S.A Company.

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