ASIACOMB New Medipharco cream to treat infections, skin fungi (10g)

Dosage form Tube x 10g
Specifications Triamcinolon acetonid, nystatin, clotrimazol, neomycin
Ingredient Fungal fungus, nail mushroom, candidia

Ingredient

Thành phần cho 10g

Composition informationContent
Triamcinolon acetonid10mg
Nystatin1000000iu
Clotrimazol100mg
Neomycin35mg

Uses

Indications

Asiacomb-new Tenamyd 10 g drug is indicated in the following cases:

  • Treatment on the spot of skin infections, skin diseases that respond to steroids or fungal diseases such as: skin fungal disease, skin fungus in addition to skin, interstitial fungi, interstitial fungus, feet of malassezia furfur, nail inflammation and around nails ...

    is a synthetic glucocorticoid gluor. Used to treat skin to treat disorders that need corticosteroids: anti -inflammatory, immunosuppressive, anti -allergy.

    Clotrimazol

    is a broad -spectrum anti -fungal active ingredient used to treat skin diseases caused by various diseases and also have effects on trichomonas, staphylococcus and bacteroides. No effect on lactobacilli.

    The mechanism of acting of clotrimazol is to link with phospholipids in the fungal cell membrane, changing the permeability of the membrane, causing loss of intracellular essential substances leading to the destruction of mushroom cells.

    nystatin

    is an anti -fungal antibiotic extracted from streptomyces nourei mushrooms, yellow powder, very little soluble in water. Nystatin has the effect of restraining or eliminating fungi depending on the concentration and sensitivity of the fungus, not affecting the normal bacteria on the body. The most sensitive is yeast and has a very good effect.

    neomycin

    A aminoglycoside antibiotic has the same mechanism and spectrum of the same effect as Gentamycin. Neomycin sensitive bacteria such as: Staphylococcus aureus, Escherichia Coli, Heamophilus Influenzae, Klebsiella, Enterobacter of all kinds, neisseria of all kinds. Neomycin is often used on the spot in the treatment of infections in the ear, eyes and skin. Because the drug is quite popular on the spot, there has been a relatively wide anti -drug notice, typically Staphylococcus staph, some Salmonella, Shigella and Escherichia Coli series. Cross -resistance to kanamicin, framycetin and paramomycin happened.

    pharmacokinetic

    triamecinolon acetonid

    Good absorption when used external especially when echoed or damaged skin causes systemic effect. Triamcinolon is distributed into all tissues in the body (muscles, liver, skin, intestines, kidneys ..). The drug passes the placenta and secretes the milk in a small amount. Triamcinolon metabolizes mainly in the liver, partly in the kidneys and the issue through the urine, and the plasma life is 2 - 5 hours. Links to plasma albumin. Discontinuation at the dose of treatment must gradually gradually until the HAP (under the adrenal pituitary gland) recovers.

    Clotrimazol

    Use topical on the skin very little absorbed. 6 hours after applying 1% Clotrimazol on the skin intact and on the skin acute inflammation, Clotrimazol concentration varies from 100 mcg/cm3 in the horny layer to 0.5 - 1 mcg/cm3 in spikes and 0.1 mcg/cm3 in the subcutaneous tissue layer. The average serum peak concentration reaches approximately 0.01 mcg/ml after 8 - 24 hours if using 5 g of Clotrimazol - 14C 0 1%.

    nystatin

    Poorly absorbed through the gastrointestinal tract, not absorbed through the skin or mucous membranes when used on the spot, excreted mainly through fertilizer in the form of unprocessed.

    neomycin

    Goods absorbing through the skin, absorbing the drug may increase when the mucosa is inflamed or damaged. When absorbed, the drug will quickly eliminate through the kidneys in the form of activity. The sale time of the drug is about 2-3 hours.

    • Before taking ASIACOMB New Medipharco cream to treat infections, skin fungi (10g)

    How to use

    topical skin.

    Dosage

    Apply a thin layer of cream on the infected area, 2-3 times a day to treat common fungal infections from 2-4 weeks.

    Note:

  • During the use of cream should not use disinfectant, should not eat crab shrimp, beef and strong wine to reduce the stimulation and damage to the skin.
  • Do not apply medicine to the eye.

    • Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    triamcinolon

    Fever, muscle pain, joint pain, rhinitis, conjunctivitis, skin pain, weight loss. Stop or reduce the dose too fast after long -term treatment can cause acute adrenal failure, hypotension and death.

    If these signs should be used immediately 1 dose of corticosteroids quickly act (put into intravenous line), then gradually reduce the dose.

    Clotrimazol

    Not found information when using overdose.

    nystatin

    Gastrointestinal lavage, then use bleach and appropriate support treatment.

    neomycin sulfate

    When signs or symptoms of toxicity with the kidneys or hearing must stop the drug immediately. Monitor kidney function and hearing. If these functions are impaired, for hemorrhage. Necessary can give prolonged respiration.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Asiacomb-New Tenamyd 10 g, you may experience unwanted effects (ADR).

    Nystatin is almost non -toxic and does not cause sensitivity and good tolerance at all ages including weak children and even for prolonged use.

    rarely

  • urticaria, foreign.

    • Rare

  • Causes on -site irritation, Steven - Johnson syndrome.

    Local reactions include minor burns, irritation, allergic dermatitis due to contact, burning pain in the skin or vagina.

    triamcinolon when used on a large scale, especially when skin damage, can cause systemic effect.

    Common
  • Reducing blood, keeping Na+, edema, hypertension, muscle weakness, muscle atrophy.

    • Less

  • thrombosis, mental disorders accompanied by emotional symptoms, adrenal insufficiency, fake Cushing symptoms, decreased protein balance, children grow slowly, diabetes, the ability to reduce, outbreaks of potential diseases such as tuberculosis, diabetes, osteoporosis, skin atrophy and muscle, difficulty wounds, glaucoma, opaque eyes under the back of the back bag (if used for prolonged use).

    • Rare

  • Increased intracranial pressure, necrotic vasculitis, intravenous inflammation, worsening infection, insomnia, fainting, stunning anaphylaxis.

    • Neomycin used on the spot

    Common
  • Sensitive hyperplasher reactions such as dermatitis, itching, drug fever and anaphylaxis.

    • Uncommon:

  • Hypermia and bilirubin enzyme, hematopoietic disorders, hemolytic anemia, confusion, abnormalities, disorientation, eyeball, increased salivation, stomatitis.

    • Using prolonged drugs can lead to dizziness, vibration of the eyeball and deaf, even after stopping the drug.

    Instructions on how to handle ADR

    Notify the doctor with unwanted effects when using the drug.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Asiacomb-new Tenamyd 10 g drug is contraindicated in the following cases:

  • Patients with skin virus disease.
  • Patients with hypersensitivity to the ingredients of the drug.

    • Precautions when using

    triamcinolon

    Use caution in patients with thyroid diseases, cirrhosis, nausical ulcerative ulcer, people at risk of stomach ulcer. Do not use for patients with impaired skin circulation. Avoid using on the face.

    Clotrimazol

    If irritated or sensitive when used to stop the medication and appropriate treatment. Must treat the drug enough time despite the symptoms of relief.

    nystatin

    If there is a hypersensory reaction, it is necessary to stop the drug immediately and take appropriate handling measures.

    neomycin

    Avoid staying in place for a long time because it can cause sensitivity on the skin and easily cross -sensitive with other aminoglycosides. The drug has a neurological -muscle -blocking effect, so it can cause respiratory inhibitors and respiratory arrest. Must be very cautious when taking drugs for patients with kidney or liver or hearing.

    The ability to drive and operate machinery

    does not affect.

    Pregnancy

    only used when really necessary.

    Breastfeeding period

    only used when necessary.

    Drug interaction

    triamcinolon

    Barbiturat, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Primidon and Aminoglutethimid increases metabolism, corticoid clearance, reduces treatment effects.

    corticosteroids antagonistic effects of hypoglycemic drugs (including insulin), antihypertensive drugs and diuretic. The effect of reducing potassium of the following drugs increases: acetazolamid, diuretic thiazid, carbenoxolon.

    Simultaneously used with Cumarin anticoagulants increases the effects of anticoagulants. It is necessary to check blood clotting time or prothrombin time to avoid spontaneous bleeding. Corticosteroids increase salicylate clearance, corticosteroids can cause salicylate poisoning.

    Clotrimazol

    There is no notice of the effect of copper or antagonism between clotrimazol and nystatin, amphotericin B or flucytosin and C. albicans.

    nystatin

    Loss of Candida Albicans resistance if used simultaneously riboflavin phosphate.

    neomycin

    Neomycin can reduce other drugs such as Phenoxymethyl Penicilin, Digoxin, which can reduce the effectiveness of oral contraceptives. Concentrated with strong diuretics such as ethacrynic acid, Furosemid increases the ability to poison the kidneys and hearing.

    Neomycin is tolerated, which can cause reduced absorption syndrome with many substances such as fat, nitrogen, cholesterol, carotene, glucose, xylose, lactose, sodium, calec, cyanocobalamin and iron. Neomycin can increase Cumarin's anticoagulant effects by reducing the reserves of Vitamin K. Concomitanting Neomycin with neurological -muscle inhibiting agents that can increase the nerve -muscle inhibitor effect and lead to respiratory paralysis. Therefore, avoid using neomycin for patients who are taking these drugs or patients with myasthenia gravis.

    Storage

    In a dry place, temperatures below 30 ° C, avoid light.

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