Aspilets EC 80mg to prevent myocardial infarction, stroke (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Acetylsalicylic acid
Ingredient United

Ingredient

Composition information	Content
Acetylsalicylic acid	80mg

Uses

Indications

Aspilets EC drug indicated to prevent recurrence for patients with a history of myocardial infarction, a history of stroke, preventive treatment for thrombosis for patients with high risk of atherosclerosis.

Prevention of recurrence for patients with a history of myocardial infarction, a history of stroke, stable and unstable angina, fleeting anemia, peripheral vascular disease, blood vessel procedures such as coronary oxygen surgery and coronary cavity surgery.

Preventive treatment for thrombosis for patients with high risk of atherosclerosis such as LDL cholesterol/high blood, men on 40 or postmenopausal women, hypertension (after control of blood pressure), smoking, diabetes, family history with coronary artery disease.

Pharmacokology

Acetylsalicylic acid has an analgesic, cooling, anti -inflammatory and anti -platelet. Acetylsalicylic acid is quickly absorbed at a high level. In adults, the concentration of treatment of salicylic acid 30 - 60mg/l plasma for pain relief and antipyretic effects, and 40 - 100mg/l plasma for anti -inflammatory effects.

The anticoagulant effect of acetylsalicylic acid is due to indirect platelet inhibition effects through the negative acetylation of plateletic cyclooxy The inhibitory effects of acetylsalicylic acid on the production of platelet threshold are still during the existence of platelets, about 8-9 days in normal people. This leads to a plateletic cycloxygenase acetyl

pharmacokinetic

While absorbed through the intestinal wall, as well as in the liver and blood, acetylsalicylic acid is hydrolyzed into salicylic acid. With a dose of 500mg acetylsalicylic acid, the sale time is 20 - 30 minutes, and 2.5 - 3 hours with salicylic acid. When using a higher dosage, the sale time of salicylic acid is more. Acetylsalicylic acid is mainly eliminated by the kidneys in the form of free or combined salicylate.

Before taking Aspilets EC 80mg to prevent myocardial infarction, stroke (10 blisters x 10 tablets)

How to use

Aspilets EC is recommended by oral. Should drink after eating. Or according to the instructions of the physician.

Dosage

The usual dose of Aspilets EC is 1-2 tablets, once a day or as directed by the physician.

What to do when overdose?

When taking a large amount of acetylsalicylic acid can lead to deep breathing, fast, tinnitus, deafness, vasodilation, sweating.

Handling poisoning includes gastreasing and monitoring of plasma pHs, plasma salicylate levels and electrolytes. It may be required to alkaline the required urine to increase the urology if the salicylate concentration in plasma is> 500 mg/l in adults or> 300 mg/l in children.

What to do when you forget 1 dose?

If you forget to take a dose of the drug, take it as soon as possible. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Aspilets EC you can experience unwanted effects (ADR).

Auxiliary reactions of acetylsalicylic acid are often associated with the digestive system such as nausea, vomiting, indigestion, abnormalities, heartburn, stomach pain, digestive ulcers, severe gastrointestinal bleeding.

Central nervous system: fatigue, (rarely) insomnia, restlessness, irritability.

DA: Ban, urticaria.

Hematology: Hemolytic anemia, (rarely) prolonged bleeding time, leukopenia, platelets.

Neurological - muscle and bone: weak muscle.

Respiratory: Difficulty breathing, (rarely) bronchospasm.

Liver, kidney (less common) toxic liver and impaired kidney function.

Other: Anaphylaxis.

Notify the doctor with unwanted effects when taking the drug.

Warnings

Contraindicated

ASPILETS EC is contraindicated in the following cases:

Patients with acetylsalicylic acid hypersensitivity or other non-steroid anti-inflammatory.

Patients with asthma, rhinitis and nasal polyps due to bronchospasm and rhinitis may be more serious in the case of acetylsalicylic acid intolerance.

Patients with a history of progressive gastrointestinal ulcer because acetylsalicylic acid can cause stomach mucosa and bleeding.

Patients with moderate and severe heart failure.

Patients with severe renal impairment and liver failure, cirrhosis.

People with bleeding and thrombocytopenia.

Note

Alcoholism: Patients who drink on 3 glasses of alcohol a day should consult a doctor when taking acetylsalicylic acid because of alcoholism is associated with the risk of bleeding.

Acetylsalicylic acid can inhibit platelet function and lead to prolonged bleeding time. Acetylsalicylic acid should be avoided in patients with genetic coagulation disorders (hemophilia) or suffering from (liver disease or vitamin K).

Be cautious when using

When treating people with mild heart failure, kidney disease or liver disease, especially when used simultaneously with diuretics, it is necessary to carefully consider the risk of water retention and the risk of reducing kidney function.

Children: Avoid using acetylsalicylic acid for children with viral fever (flu or chickenpox) because of the risk of Reye syndrome, a rare but serious disease on the liver and nervous system that can lead to coma and death.

Pregnancy or breastfeeding

For pregnant women: only acetylsalicylic acid should be used if it is really necessary because it can cause early arteriosclerosis and labor delay. Avoid use in the last three months of pregnancy (because of the risk of bleeding during birth).

For breastfeeding women: Do not use acetylsalicylic acid because salicylate is excreted through breast milk. High doses can cause rash, platelet deformities and bleeding in breastfeeding.

Driving and operating machinery

This drug usually does not affect the ability to drive and operate machinery

Medicinal interaction

using acetylsalicylic acid can lead to increased concentration of acetazolamide, reducing total phenytoin levels and increasing serum valproic acid levels.

Acetylsalicylic acid may reduce the effect of lowering the blood pressure of beta inhibitors and diuretics, reducing the effect of lowering blood pressure and sodium/blood lowering of the enzyme inhibitors. Salicylate can inhibit the kidneys in the kidneys of methotrexate leading to bone marrow poisoning, especially in the elderly or patients with renal impairment. Acetylsalicylic acid should be avoided at the same time with other anti -inflammatory drugs - steroids and other anticoagulants (heparin and warfarin) due to increased risk of bleeding. Salicylate antagonists acting with drugs that increase uric acid secretion in urine (probenecid and sulfinpyrazone).

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

Expiry date: 24 months from the date of production.

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