Aspirin 81 Agimexpharm prevents myocardial infarction, stroke (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Acetylsalicylic acid
Ingredient Stroke, myocardial infarction, psoriasis, thrombosis

Ingredient

Composition information	Content
Acetylsalicylic acid	81mg

Uses

Indications

Aspirin 81 drug used to prevent primary and secondary preventive infarction, stroke.

Pharmacokic

The inhibited inhibitors of Cycloxygenase (COX), leading to prostaglandin synthesis inhibitors. Cells with new COX synthesis will be able to continue synthesizing prostaglandin, after salicylic acid levels decrease. Platelets are non -nucleus cells, unable to synthesize new COX, so the COX is inhibited, until platelets are created.

Aspirin also inhibits prostaglandin in the kidneys. Prostaglandin production in the kidneys is less physiologically important to patients with normal kidneys, but plays a very important role in maintaining blood circulation through the kidneys in people with chronic kidney failure, heart failure, liver failure or there is a disorder of plasma volume. In these patients, prostaglandin synthesis effects in the kidneys of aspirin can lead to acute renal failure, water retention and acute heart failure.

pharmacokinetic

absorption

Acetylsalicylic acid absorbs well through the gastrointestinal tract. Acetylsalicylic acid that is decomposed into salicylic acid also has a pharmacological effect similar to acetylsalicylic acid. Oral bioavailability is about 68% ± 3.

Distribution

The drug is associated with plasma proteins by about 49% (increasing blood urea that reduces the drug with plasma proteins). The distribution volume is about 0.15 ± 0.03 liters/kg.

Metabolism and elimination

The clearance of the drug: 9.3 ± 1.1 ml/min/kg and may change in the elderly and cirrhosis. The sale time of the drug is about 0.25 ± 0.03 hours, the semi -waste time changes in people with hepatitis. The drug excretes the kidneys mainly in the form of free salicylic acid and conjugate metabolites.

Before taking Aspirin 81 Agimexpharm prevents myocardial infarction, stroke (20 blisters x 10 tablets)

How to use

Take the whole pill after eating, do not chew or crush.

Dosage

Common dose used in long -term treatment 1-2 capsules 1 time/day. In some cases, it may be suitable for higher doses, especially in short -term treatment and may be used up to 4 capsules/day according to the doctor's instructions.

What to do when overdose?

Clinical symptoms

Breathing fast, deep, tinnitus, deafness, vasodilation, sweating.

Handling

Clean the stomach by causing vomiting (careful attention to not inhale) or gastric lavage, drinking activated carbon. Monitor and support the necessary functions for life. High fever treatment; Infusion, electrolytes, acid imbalance correction - base; treatment of ceton accumulation; Keep the concentration of suitable blood glucose.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using aspirin 81, you may experience unwanted effects (ADR).

Common

Digestive: Nausea, vomiting, indigestion, discomfort in the epigastric, heartburn, stomach pain, stomach ulcer. Breathing.

Other: Anaphylaxis.

Central nervous system: insomnia, restlessness, irritability. Management.

Instructions on how to handle ADR

ADR on the central nervous system can recover completely within 2-3 days after the drug stopped.

If there are symptoms of dizziness, tinnitus, hearing loss or liver damage, it is necessary to stop the drug.

In the elderly, the lowest dose of aspirin is effective and in the shortest possible time.

Anaphylaxis treatment due to aspirin with therapy is the same as when treating acute anaphylactic reactions. Adrenalin is a selective drug and often easily controlled angels and urticaria.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ASPIRIN 81 drug is contraindicated in the following cases:

Hypersensitivity to the derivatives of Salicylat and NSAID.

People with a history of asthma. Gout or a history of gout.

Precautions when using

Aspirin content of 81 mg is not suitable for fever, anti -inflammatory, analgesic indications.

Should be used for patients 16 years and older. Do not use for patients under 16 unless the expected benefits are greater than the risks. Acetylsalicylic acid can be a factor that contributes to Reye syndrome in children.

Be careful before surgery, stop temporary treatment if necessary. Because it may increase the risk of serious bleeding during or after surgery (even small surgery such as tooth extraction).

Should not be used during menstruation because it can increase menstrual bleeding.

Be cautious in cases of high blood pressure and patients with a history of stomach, duodenal or hemorrhage or are being treated with anticoagulant therapy.

Should report to your doctor any abnormal bleeding symptoms. Treatment should be stopped if bleeding or gastrointestinal ulcers.

Be careful when taking acetylsalicylic acid in medium or decreased liver impaired patients (contraindicated if serious) or in patients with dehydration because of non -steroid anti -inflammatory drugs (NSAIDs) can lead to impaired renal function.

Do not simultaneously use Aspirin 81 with anticoagulic drugs, thrombolytic drugs and platelet resistance, nonsteroidal anti -inflammatory drugs and inhibiting selective Serotonin reabsorption because of the increased risk of bleeding. If the combination is inevitable, closely monitor the signs of patient bleeding.

The risk of hypoglycemia with sulfonylure and insulin may increase when used with aspirin 81.

The ability to drive and operate machinery

No information.

Pregnancy

Aspirin inhibits cyclooxygenase and prostaglandin production, leading to pipe closing. Aspirin also inhibits the contractions of the uterus, thus delaying labor. Prostaglandin production effects can lead to early closing of the circuit in the uterus, with a serious risk of pulmonary hypertension and neonatal respiratory failure. The risk of bleeding increases in both mother and fetus, because aspirin inhibits platelet aggregation. Therefore, do not use aspirin in the last 3 months of pregnancy.

Do not use aspirin in women trying to conceive or in the first 3 months and middle 3 months of pregnancy unless really necessary. If used, it should be used for low doses and the shortest possible time.

Breastfeeding period

aspirin into breast milk, but with normal treatment dose there is very little risk of harmful effects in breastfed babies.

may be treated for short -term Aspirin 81 during breastfeeding. In case of long -term use or high doses of aspirin, the drug should be stopped.

Drug interaction

Do not combine Aspirin 81 with methotrexate (dose> 15 mg/week) because of the increased risk of hematology due to Aspirin 81 reduces the amount of methotrexate through the kidney.

Aspirin 81 reduces the uric acid excretion through the kidney thus reduces the effects of drugs: Probenecid and sulphinpyrazol.

Be careful when using Aspirin 81 simultaneously with anticoagulants such as warfarin, heparin, cooumarin, phenindion because of the increased risk of bleeding (due to Aspirin anti -platelet effects).

Aspirin 81 increases the risk of gastrointestinal bleeding when used simultaneously with plateloon anti -binding agents (clopidogrel, dipyridamol), selective inhibitors of Serotonin reabsorption (Sertralin, paroxetin).

Aspirin 81 increases the hypoglycemic effect of sulphonylure.

Aspirin 81 reduces the kidney excretion of digoxin and lithium. It is necessary to monitor the concentration of digoxin and lithium when treated with aspirin 81, which can be adjusted if necessary.

Aspirin 81 reduces the effect of lowering the blood pressure of diuretics and other antihypertensive drugs, increasing the risk of acute renal impairment when used simultaneously with enzyme inhibitors and Angiotensin II body blockers.

Simultaneous use of Aspirin 81 with carbonic anhydrase inhibitors (acetazolamid) can be severe and increased the toxicity of the central nervous system.

When treating the combination of Aspirin 81 with corticosteroids will increase the risk of stomach ulcers and gastrointestinal bleeding.

Aspirin 81 should not be used in combination with other NSAID drugs because of the increase in side effects such as increasing the risk of ulcers and gastrointestinal bleeding due to the synergistic effect.

Experimental data shows that ibuprofen inhibits the anti -platelet aggregation effect of Aspirin 81 when used simultaneously.

Simultaneous use of Aspirin 81 with ciclosporin or tacrolimus may increase the toxicity of the kidneys of Cilosporin or Tacrolimus. The function of the kidney should be monitored in case of simultaneous use of these drugs with aspirin 81.

There has been an aspirin 81 report that reduces the cohesion of anti -epileptic drugs (Phenytoin, Valproot) with serum abumin. Therefore increasing the concentration of freedom of phenytoin and valproat in plasma in a stable state.

Simultaneous use of alcohol and aspirin 81 will increase the risk of gastrointestinal bleeding. Antacids that reduce the effects of aspirin 81 due to urine will increase aspirin excretion.

Storage

Leave a cool place, avoid light, temperature below 30 ° C.

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