Aspirin PH8 pH Mekophar reduces mild and medium pain, reduces fever (20 blisters x 10 tablets)

With antipyretic effects, like many other related drugs, aspirin works on heat adjustment centers in the brain to cool down the body through vasodilation in the skin. The usual dose of aspirin to reduce pain and reduce fever is 0.3 - 1 g that can be repeated according to clinical needs, maximum 4 g/day.

Aspirin is used in the treatment of chronic and chronic joints. Maximum inhibition of rheumatoid symptoms that occur with plasma concentrations about 300 μg/ml, but this concentration is often minor toxicity such as nausea and tinnitus, which can completely achieve control of the symptoms of rheumatism with lower concentrations. In chronic rheumatism, 300 - 900 mg is injected every 4 hours for a long time. In acute rheumatism, 4 - 8 g per day is divided into 2 doses that are sometimes recommended, but the initial dose is 150 mg/kg/day.

Dynamic pharmacokinetics

absorption: aspirin without ionization is absorbed in the stomach. Acetylsalicylate and salicylate are also easy to absorb in the intestine.

Distribution: Salicylate on a large area with plasma proteins, aspirin binding at a lower level. Aspirin and Salicylat are quickly distributed to all body tissues; They appear in breast milk and overcome the placenta fence.

Metabolism: Salicylic acid hydrolysis occurred quickly in the intestine and in the circulatory system.

Elimination: Aspirin is excreted in the form of salicylic acid, glucuronid compounds, Gentisic acid. The rate of aspirin excretion varies with the pH of the urine, increasing when the pH increases and the maximum at 7.6 or more.

Anti -arthritis of teenagers.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Salicylate plasma concentration is over 300 mg/l, plasma concentrations above 500 mg/l in adults and 300 mg in children often cause serious poisoning.

Symptoms of moderate poisoning: Tinnitus, hearing disorders, headache, dizziness, confusion and gastrointestinal symptoms (nausea, vomiting and abdominal pain).

Serious toxic symptoms: Symptoms are related to serious alkali - acidic balance. The first stage of increased ventilation, leading to respiratory and respiratory. Next is respiratory acidosis due to inhibited respiratory center. In addition, metabolic acidosis occurs due to the presence of salicylat. Children are often not detected at the early stage of poisoning until they are in acidosis.

Other possible symptoms are: increased body temperature and sweat leading to dehydration, restlessness, convulsions, hallucinations and hypoglycemia. Weakness of the body of the body leads to coma, cardiovascular collapse or apnea.

Management:

Clean the stomach by causing vomiting (pay attention to not inhale) or gastrointestinal, drink activated carbon. Monitor and support the necessary functions for life. High fever treatment, infusion, electrolyte, correction of acid-base imbalance; treatment of ceton accumulation; Keep the appropriate blood glucose concentration. Monitor the serum salicylate concentration until it is clear that the concentration is decreasing to the point of non -toxic.

In addition, it is necessary to monitor for a long time if it is overdosed of a large extent, because the absorption may last; If the test is performed from drinking to 6 hours before the Salicylate poisoning concentration, it is necessary to repeat the test. Causing the urinary tract with alkalinization of urine to increase salicylate excretion. However, oral bicarbonate should not be used because it can increase Salicylate absorption.

If acetazolamid is used, it is necessary to carefully consider the risk of serious metabolic acid infection and salicylate poisoning (due to increased salicylate penetration into the brain due to metabolic acid infection). Perform blood transfusion, hemorrhage, abdominal separation when overdose if needed. Monitor pulmonary edema and convulsions, perform appropriate therapy if needed. Blood transfusion or vitamin K if needed to treat bleeding. Actively monitor for timely measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

When used simultaneously with other drugs, to avoid the risk of overdose, it is necessary to check to ensure that acetylsalicylic acid does not exist in the composition of those drugs.

Prolonged treatment with high dose painkillers, when headaches appear should not increase the dose of treatment. Regular use of painkillers, especially a combination of painkillers can lead to persistent kidney damage with the risk of kidney failure.

Reye syndrome is very rare but life -threatening, which has been observed in children with signs of viral infection (especially chickenpox and influenza disease) and treatment with acetylsalicylic acid. Therefore, acetylsalicylic acid should be used only for children when other treatments fail. In the case of prolonged vomiting, abnormal consciousness or abnormal taste, acetylsalicylic acid treatment should be stopped.

In some cases of severe G6PD deficiency, high -dose aspirin can cause hemolysis. Treatment with acetylsalicylic acid in the case of G6PD deficiency should be performed under medical supervision.

Treatment supervision should be strengthened in the following cases:

Concomitance this drug is not recommended for:

Should monitor the overdose signs when using high doses of aspirin in rheumatism.

In case of tinnitus, hearing loss and dizziness, the treatment needs to be re -evaluated.

Elderly people may have aspirin poisoning, likely due to impaired renal function, need to use lower doses than conventional doses for adults.

Should monitor bloodlic acid levels in children, especially during the first treatment.

Do not give children under 6 years old to take the whole tablet because the drug is at risk of entering the respiratory tract.

Preparation 500 mg is not suitable for children under 30 kg, using other drugs with more appropriate doses.

Preparations containing lactose monohydrates, caution for patients with rare genetic disorders in galactose tolerance, lactase deficiency, or glucose-galactose absorption disorders.

The ability to drive and operate machinery

Caution when used for operators, train drivers, higher people working and other cases because the drug can cause fatigue, drowsiness.

Pregnancy

Pregnant women: (dose ≥ 500 mg/day)

Prostaglandin synthesis inhibitors may affect pregnancy and/or embryo or fetal development. Data from epidemiological studies shows an increase in the risk of miscarriage, heart defects and abdominal hernia after treatment with prostaglandin synthesis inhibitors at the beginning of pregnancy. The risk of cardiovascular defects increases from the bottom to about 1.5%. The risk increases depending on the dosage and treatment time.

Unless it is necessary, acetylsalicylic acid should not be used for the first 24 weeks of pregnancy (5 -month -old pregnancy). If acetylsalicylic acid needs to be used for women who intend to become pregnant or pregnant less than 6 months (5 -month -old pregnancy), the lowest treatment should be used and the shortest possible treatment time.

In the last 3 months of pregnancy, all Prostaglandin synthesis inhibitors can make the fetus susceptible:

During the end of pregnancy, the mother and the fetus may have:

Combining closely monitoring: