Asthmatin 10 Stella prevents and treats asthma, reduces allergic rhinitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Montelukast
Ingredient Allergic rhinitis, bronchial asthma

Ingredient

Composition information	Content
Montelukast	10mg

Uses

Indications

ASTHMATIN 10 mg is indicated in the following cases:

prevention and long -term treatment of asthma in adults and children aged 12 months and older.

Symptoms of allergic rhinitis (seasonal allergic rhinitis and children 2 years and older and allergic rhinitis year -round in adults and children aged 6 months and older). Released from many different cells, including mast cells and eosinophilia. These eicosanoids are associated with Leukotrien cysteine receptors (CYSLT).

Cyst Typ-1 receptor (CYSLT1) is found in humans (including smooth muscle cells and respiratory macrophages) and other inflammatory cells (including eol only and some bone marrow cells).

CYSLTS is correlated with asthma and allergic rhinitis. In asthma, the indirect effects of Leukotrien include respiratory edema, smooth muscle contraction and transforming cell activity related to inflammatory process.

In allergic rhinitis, CYSLTS is released from the nasal mucosa after exposure to allergies in both early phase and late phase reactions with symptoms of allergic rhinitis. The stimulation in the nose caused by CYSLTS shows increased respiratory resistance through the nose and increases the symptoms of nasal congestion.

Montelukast is an oral activity associated with CYSLT1 receptor with high pressure and selection (rather than other important pharmacological receptors in the respiratory tract such as Prostanoid receptors, cholinergic or beta-adrenergic). Montelukast inhibits the physiological impact of Ltd, at CYSLT receptor without any owner activity.

pharmacokinetics

Montelukast's peak plasma concentration is achieved after 3-4 hours of taking medicine. The average oral bioavailability is 64%. Montelukast is connected to plasma proteins over 99%. The drug is widely metabolized in the liver thanks to the isoenzyme of Cytochrom P450 is CYP3A4, CYP2A6 and CYP2C9, and excreted mainly into the fertilizer through bile.

Before taking Asthmatin 10 Stella prevents and treats asthma, reduces allergic rhinitis (3 blisters x 10 tablets)

How to use

Asthmatin should drink once a day. For asthma, take medicine in the evening. For allergic rhinitis, the time to take medicine can be personalized to suit the needs of each patient. Patients who have asthma and allergic rhinitis should only take 1 capsule daily in the evening.

Dosage

Adults and adolescents aged 15 and older with asthma or allergic rhinitis: 10 mg x 1 time/day.

Children 6 - 14 years old with asthma or allergic rhinitis: 5 mg x 1 time/day.

Children 2 - 5 years old with asthma or allergic rhinitis: 4 mg x 1 time/day.

Children 12 - 23 months of age have asthma: 4 mg x 1 time/day.

Children 6 - 23 months of age allergic rhinitis all year round: 4 mg x 1 time/day.

Safety and effectiveness of treatment in children under 6 months of age have allergic rhinitis all year round and in children under 12 months of age with unprocessed asthma.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In chronic asthma studies, Montelukast is used at a dose of up to 200 mg/day for adult patients for 22 weeks and in short -term studies, 900 mg/day for patients for about 1 week without a clinical non -desire reaction. In case of overdose, common support measures may be used such as eliminating non -absorbing substances in the gastrointestinal tract, clinical monitoring and starting treatment, if necessary.

There are reports on acute overdose occurring in children with Montelukast at least 150 mg/day. Clinical and experimental findings in accordance with the summary description of safety in adults and older children. There is no unwanted effect that is reported in most cases of overdose. The most common unwanted effect is thirst, drowsiness, pupils, increased movement and abdominal pain.

It is unknown whether Montelukast is excluded by the abdominal separation or hemorrhage.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using ASTHMATIN 10 mg you may experience unwanted effects (ADR).

Very common, ADR

Infection and parasitic infection: upper respiratory infection.

The immune system: The hypersensitivity reactions include anaphylaxis.

Common, 1/100

Digestive: diarrhea, vomiting, nausea.

Liver - bile: Increased serum transaminase concentration (ALT, AST).

Skin and surplus skin: ban.

Systemic: Fever.

Uncommon, 1/1000

Mental: Abnormal dreams such as nightmares, insomnia, sleepwalking, anxiety, agitation include acts of aggression or hostility, depression, mental hyperactivity (including irritability, restlessness, tremor).

Less nervousness: dizziness, drowsiness, paresthesia/reducing sensation, epilepsy.

Respiratory, chest and mediastinum: nosebleeds.

Digestive: dry mouth, indigestion.

Skin and skin tissue: bruising, urticaria, itching.

Muscle - Bone and connective tissue: joint pain, muscle pain including muscle cramps.

Systemic: weakness/fatigue, discomfort, edema.

Rare, 1/10000

Blood and lymph: Increased bleeding trend.

Mental: Attention disorders, memory impairment.

Cardiovascular: Brush the chest drum.

Skin and subcutaneous tissue: Evaluation.

Very rare, ADR

The immune system: even leukemia in the liver.

Mental: illusion, disorientation, thoughts and suicide behavior.

Respiratory, chest and mediastinum: Churg-strauss syndrome (CSS), Eosin hyperpens in the lungs.

liver - bile: hepatitis (such as bile stasis, liver cancer, and mixed liver damage).

Skin and skin surplus: Rose button, diverse roses.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ASTHMATIN 10 mg is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Precautions when used

bronchospasm in acute asthma attacks.

advise patients with appropriate emergency drugs.

Can continue treatment with Montelukast during severe asthma attacks.

While reducing the dose of corticosteroids spray slowly under medical monitoring, Montelukast should not be used instead of corticosteroids spray or oral form.

Do not use Montelukast as a single -treatment therapy for treatment and control of bronchospasm due to activity.

Patients with severe asthma after activity should continue the common treatment regime with the spray beta -shifting drug owner to prevent and can use the Beta -shaped spray owner with short effects for emergency.

Patients sensitive to aspirin should avoid continuing to take aspirin or nonsteroidal anti -inflammatory drugs while taking Montelukast. Although Montelukast takes effect in improving respiratory function in people with asthma sensitivity to aspirin, it has not yet been shown to be removed from the bronchial contract caused by Aspirin and other nonsteroidal anti -inflammatory drugs in aspirin sensitive asthma patients.

Patients with rare genetic problems are galactose intolerance, lapp lactase deficiency, or Glucose-Galactose.

The ability to drive and operate machinery

Montelukast is said to do not affect the ability to drive and operate machinery, but some rare cases cause drowsiness, dizziness.

Pregnancy

There are no complete and well -controlled studies in pregnant women. Because animal reproduction studies do not always predict to be met in humans, only Montelukast should be used if it is really necessary.

Breastfeeding period

It is unknown whether Montelukast is excreted in breast milk or not. Because many drugs are excreted on breast milk, it is cautious when using Montelukast in breastfeeding mother.

Drug interaction

In Montelukast's recommended interaction, clinical doses, there is no clinical important effect on the pharmacokinetics of the following drugs: Theophylllin, prednisolon, oral contraceptive contraceptive (Ethinyl estradiol/norethindroon 35/1), Terfenadin, Terfenadin and Terfenadine Warfarin.

Montelukast's area under the curve (AUC) decreases by about 40% in users simultaneously with phenobarbital. Because Montelukast is metabolized by CYP 3A4, 2C8 and 2C9, should be used carefully, especially in children, when used simultaneously with CYP 3A4, 2C8 and 2C9 induction substances such as phenytoin, phenobarbital and rifampicin.

In vitro studies show that Montelukast is a strong CYP 2C8 inhibitor. However, information from a clinical medical interactive study related to Montelukast and Rosiglitazon (the exploration substrate represents the main metabolic drugs mainly by CYP 2C8) has proven that Montelukast does not inhibit CYP 2C8 In Vivo. Therefore, Montelukast is unpredictable that significantly changes the metabolism of drugs metabolized by this enzyme (such as Paclitaxel, Rosiglitazon and Repaglinid).

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

Expiry date: 24 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

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