A.T Fexofenadin 30mg/5ml An Thien Treatment Treatment for allergic rhinitis, indefininant urticaria (30 packs x 5ml)

Dosage form Drink
Specifications 30 package box
Ingredient Fexofenadin hydrochlorid

Ingredient

Thành phần cho 5ml

Composition information	Content
Fexofenadin hydrochlorid	30mg

Uses

Indications

oral fluid A.T Fexofenadin 30mg/5ml is indicated for treating symptoms in seasonal allergic rhinitis, indefinite urticaria in adults and children over 6 years old.

Pharmacology

Pharmacological group: 2nd generation antihistamine resistance, receptor resistance H1

ATC code: R06AX26

Fexofenadine is a second -generation antihistamine, which has a specific antagonistic and selective effect on peripheral H1 receptors. The drug is a metabolic substance that has the activity of terfenadine, also competing with histamines at H1 receptors in the digestive tract, blood vessels and respiratory tract, but no more toxic to the heart due to not inhibiting potassium channel related to myocardial cycles. Fexofenadine has no significant effect on acetylcholin, dopamine antagonism and has no effect of inhibiting Alpha 1 or beta-adrenergic receptors. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into H1 receptors, forming a sustainable complex and slowly separated.

pharmacokinetics

absorption:

Good absorption drug when taken oral and start to work after drinking 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (to about 4 hours). The antihistamine effect lasts more than 12 hours. The ratio of cohesion with plasma proteins of the drug is 60-70%, mainly with albumin and alpha1-acid glycoprotein.

Distribution:

It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadine has detected fexofenadine as a metabolic substance of terfenadin in breast milk. Fexofenadine does not pass the blood - brain barrier.

Metabolism and elimination:

Fexofenadine is very small metabolized (about 5%, mainly in the intestinal mucosa, only about 0.5-1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non-active substances). About 3.5% of fexofenadine dose metabolized through phase II (not related to the cytochrom f450 enzyme system) into methyl ester derivatives. This metabolite is only seen in the stool, so there may be the participation of intestinal bacteria into this metabolism. FEXOFENADINEAADELINE SELLING TIME OF 14.4 hours, lasting longer (31-72%) in kidney failure people. The drug excreted mainly in feces (approximately 80%) and urine (11-12%) in constant form.

Pharmacokinetics in people with renal failure:

CLCR 41 - 80 ml/minute: The peak concentration is 87%high, the selling time is longer than 59%.

CLCR 11 - 40 ml/minute: The peak concentration is higher than 111%, the sale time is longer than 72%.

CLCR ≤ 10 ml/minute (in the person who is performing the fertilizer): the peak concentration is 82% and the sale time is 31% longer than a healthy person.

Before taking A.T Fexofenadin 30mg/5ml An Thien Treatment Treatment for allergic rhinitis, indefininant urticaria (30 packs x 5ml)

How to use

A.T Fexofenadin oral. Do not drink with fruit juice. The time to take the drug does not depend on the meal.

Note: Shake carefully before use.

Dosage

Allergic rhinitis:

Adults and children over 12 years old: 60mg x 2 times/day or 180mg, taken 1 time/day.

Children from 2 to 11 years old: 30mg x 2 times/day.

Adults and children aged 12 years and older: 60 mg x 2 times/day or 180 mg, oral 1 time/day. Children from 6 months to 2 years old: 15mg x 2 times/day.

Children aged 12 years and older and adults with kidney failure, the elderly: Start using 60mg dose, take 1 time/day, adjust the dose according to the kidney function. referendum. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling: Using conventional measures to remove the drug that has not been absorbed in the digestive tract. Support support and treatment.

Hemolysis reduces the concentration of drugs in the blood (1.7%). There is no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

In control clinical studies, the unwanted effect rate in the patient group using Fexofenadine is similar to the Placebo group. The unwanted effects of the drug are not affected by the dosage, age, gender and race of the patient.

Common, ADR> 1/100

Neurological: Drowsy, tired, headache, insomnia, dizziness. 1/100

Neurological: Fear, sleep disorders, nightmares.

Digestive: dry mouth, abdominal pain.

Skin: Ban, urticaria, itching.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

A.T Fexofenadin 30mg/5ml contraindicated in the following cases:

Hypersensitivity to Fexofenadine, Terfenadine or any ingredients of the drug.

Caution when using

should be cautious and adjust the appropriate dose when taking the drug for people with impaired kidney function because the concentration of drugs in plasma is increased due to prolonged semi -waste time.

Be cautious when taking medicine for the elderly (over 65 years old) because there is often a impaired renal function.

Safety and effectiveness of drugs in children under 6 months of age has not been determined.

It is necessary to stop Fexofenadine at least 24-48 hours before conducting injection antigen tests.

Use Fexofenadine to make psoriasis worse.

This drug contains sorbitol and sucrose. The use of it is not recommended in non -intolerance fructose, malpuses and galactose or deficient enzymes sucrase/ isomaltase.

This drug contains methyl hydroxybenzoate and propyl hydroxybenzoate, which can cause allergic reactions (can be delayed).

The effect of the drug on the ability to drive and operate machinery

Although Fexofenadine is less drowsiness, but still need to be cautious while driving, control machines or perform activities that require alertness.

Use drugs for women during pregnancy and lactation

Pregnant women:

Because there is no complete research on pregnant women, only Fexofenadine is used for pregnant women when the maternal benefits are superior to the risk of the fetus.

breastfeeding women:

It is clear whether the drug is excreted through milk or not, even though it has not seen unwanted effects in newborn babies when breastfeeding mothers use fexofenadine, so be careful when using fexofenadine for breastfeeding women.

Drug interaction

erythromycin and ketoconazole increases fexofenadine levels in plasma but does not change the QT range.

Fexofenadine concentration may be increased by erythromycin, ketoconazole, verapamil, p-glycoprotein inhibitors. Do not simultaneously use fexofenadine with antacids containing aluminum, magnesi because it will reduce the absorption of fexofenadine.

Fexofenadine may increase alcohol concentration, central nervous sedatives (TKTW), anti -cholinergic substances.

Fexofenadine may reduce the concentration of acetylcholinininiserase inhibitors (in TKTW), Betahistin. Fexofenadine may be reduced by concentrations by acetylcholininininiserase inhibitors (in TKTW), amphetamine, antacids, grapefruit juice, rifampin.

Cavalry:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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