A.T ibuprofen syrup syrup 100mg analgesic, anti -inflammatory (60ml)

Dosage form Chaos
Specifications Bottle x 60ml
Ingredient Ibuprofen

Ingredient

Thành phần cho 5ml

Composition information	Content
Ibuprofen	100mg

Uses

indicated

oral fluid A.T ibuprofen syrup indicated treatment in the following cases:

Mild to medium analgesic in some cases such as menstruation, headache, toothache, analgesic and inflammation in soft tissue trauma. Inflammation and pain relief steroid

ATC code: M01AE01

ibuprofen is an nonsteroidal anti -inflammatory drug, derived from propionic acid. Ibuprofen has analgesic, antipyretic and anti -inflammatory effect.

The mechanism of action of the drug is Prostaglandin Synthetase inhibitors and thus prevents prostaglandin, thromboxane and other products of cyclooxygenase. Ibuprofen also inhibits prostacycline synthesis in the kidneys and may cause water stasis risk due to reducing blood flow to the kidneys, need to pay attention to this for patients with kidney failure, heart failure, liver failure and disorders with plasma volume disorders.

Ibuprofen's anti -inflammatory effects appear after two days of treatment. Ibuprofen has a stronger antipyretic effect than aspirin, but inferior to Indomethacin. The drug has good anti -inflammatory effects and has good analgesic effect in the treatment of teenagers.

pharmacokinetics

ibuprofen well absorbed in the digestive tract. The maximum concentration of the drug in plasma is achieved after 1 to 2 hours.

The drug is greatly attached to plasma proteins. The sale time is about 2 hours. Ibuprofen eliminates very quickly through the urine (1% in constant form, 14% in the form of combined).

Before taking A.T ibuprofen syrup syrup 100mg analgesic, anti -inflammatory (60ml)

How to use

A.t ibuprofen syrup oral fluid.

The distance between 2 doses is about 6 - 8 hours, (or at least 4 hours).

Do not use for children under 3 months old, weight

Only use in a short time.

Children over 6 months of age: If the symptoms of children last more than 3 days must consult a doctor.

Children 3 - 6 months of age: If the symptoms of children last more than 24 hours must consult a doctor.

If symptoms do not decrease or worse, consult a doctor.

Dosage

Dosage recommendations for pain and fever:

For children weighing 5 kg or more: 20 mg/kg body weight/day, divided 3 times a day. I 1 - 3 years old: dose 5 ml/time (measuring with a measuring cup) x 3 times/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

Symptoms when using ibuprofen overdose include: nausea, vomiting, epigastric pain, or sometimes diarrhea, tinnitus, headache and gastrointestinal bleeding can also occur. Poisoning is more serious than toxicity on the central nervous system, manifested as drowsiness, sometimes stimulating and disorientation or coma. Sometimes patients develop convulsions. Serious metabolic acidosis may occur and the prothrombin time may be prolonged, possibly due to the intervention of coagulation factors. Nephritis, liver failure can occur. Causing acute asthma in asthma patients.

Management:

usually treat symptoms and support. If you have overdose, you need to apply the following measures to increase elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt bleach. If severe, hemorrhage or blood transfusion. Because the drug causes metabolic acidosis and elimination in the urine, in theory, it will be beneficial for alkaline and diuretic infusion.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

5 -15% of patients have digestive side effects.

Common, ADR> 1/100:

Systemic: Fever, fatigue.

Systemic: Allergic reactions (especially bronchospasm in patients with asthma), rhinitis, urticaria. decrease.

Blood: prolonged bleeding time.

Body: edema, rash, Stevens - Johnson syndrome, hair loss. Extraordinary liver function probes, liver poisoning.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

A.t ibuprofen syrup is contraindicated in the following cases:

Hypersensitivity to ibuprofen or any ingredients of the drug. different. period.

Be cautious when using

be cautious when using ibuprofen for the elderly.

ibuprofen can cause transaminase to increase in the blood, but this transformation is transient and recovered.

Visual disorders like blurred vision are subjective signs and are related to the harmful effects of the drug but will end when stopping ibuprofen.

The drug can impair kidney function and worsen renal failure.

Liver dysfunction may occur.

Patients with a history of hypertension, heart failure, and water keeping should notify the doctor or pharmacist before using ibuprofen.

Use ibuprofen, especially at high doses (2400 mg daily) and in long -term treatment may increase the risk of arterial thrombosis (myocardial infarction or stroke).

Cycloxygenase inhibiting anti -inflammatory drugs Prostaglandin can impair female fertility due to ovulation. This may end when stopping treatment.

Be cautious when used for patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease). Anti -inflammatory NSAIDs can worsen these diseases.

Gastrointestinal hemorrhage, ulcers or perforation, can be fatal, have been reported to all NSAIDs occurring during treatment, with or without warning of symptoms or a history of previous disease.

The risk of gastrointestinal bleeding, ulcers or perforation increases when increasing the dose of NSAIDs, in patients with a history of ulcer, and in the elderly. These patients should be treated at the lowest dose possible. Abnormal abdominal symptoms should be monitored (especially gastrointestinal bleeding), especially in the early stages of treatment.

Be cautious in patients treating simultaneous medications may increase the risk of ulcerative or gastrointestinal bleeding, such as oral corticosteroids, Warfarin anticoagulants, SSRIs, or platelet assemblies such as aspirin. When gastrointestinal hemorrhage or ulcers occurs in patients using ibuprofen, treatment should be stopped.

ibuprofen inhibits platelet capacitors, so it can cause prolonged bleeding time, thus using caution with patients with lack of blood clotting factors and using anti -coagulation drugs.

Autodium warning:

Excipients with sucrose and sorbitol, patients with fructose tolerance treatment disorders, glucose absorption - galactose absorption disorders or the deficiency of sucrose - isomaltase should not use this drug.

Red excipients erythrosin, which is at risk for allergic reactions.

The effect of the drug on the ability to drive and operate machinery

The drug can cause unwanted effects such as headache, drowsiness, fatigue, dizziness, visual disorders, hearing loss. So during the time of using the drug should not drive and operate machinery.

Use drugs for women during pregnancy and nursing mothers

Due to the effects of nonsteroidal anti -inflammatory drugs on the cardiovascular system and respiration of pregnant women and fetuses, Ibuprofen should be avoided during pregnancy. In the last 3 months of pregnancy, it must be very limited to use for ibuprofen as well as any anti -inflammatory drugs and contraindicated for a few days before birth.

ibuprofen into breast milk is very small, negligible. Less likely to occur risks for children at normal doses with mothers.

Interactive drug

Other nonsteroidal anti -inflammatory drugs: may increase the risk of bleeding and ulcer.

ibuprofen should be avoided in combination with aspirin: Unless low -dose aspirin (

Experimental data shows that ibuprofen can inhibit the effects of low -dose Aspirin anti -platelet doses.

ibuprofen should be cautious when used in combination with anticoagulant drugs: NSAIDs can increase the effect of anticoagulants, such as warfarin causing non -grip bleeding.

Hematopsius and diuretics: NSAIDs can reduce the effects of these drugs. Diuretics can increase the risk of kidney toxicity of NSAIDs.

corticosteroid: increases the risk of stomach ulcers or bleeding.

Anti -plateletic anti -platelet and reconfacitely inhibitors Serotonin (SSRIs): Increased risk of gastrointestinal bleeding.

Lithi: There is evidence for an increase in plasma concentrations of lithium.

Quinolone antibiotics: Increase the side effects of Quinolone antibiotics on the central nervous system and can lead to convulsions.

Magnesi Hydroxyd increases the initial absorption of ibuprofen, but if aluminum hydroxyd is present, it does not have this effect.

methotrexate: ibuprofen increases methotrexate in plasma and increases the toxicity of methotrexate.

Furosemid: Ibuprofen can reduce the effect of sodium sodium output of Furosemid and diuretics.

Digoxin: Ibuprofen worsen heart failure, reduce GFR and increase plasma digoxin concentrations.

ciclosporin: increases the risk of kidney toxicity.

Zidovudin: Increasing the risk of hematology when using NSAIDs with zidovudin. Increased risk of hemarthrosis and hematoma in HIV patients (+) or bleeding during simultaneous treatment Zidovudin and ibuprofen.

tacrolimus: increases the risk of kidney toxicity when using NSAIDs with tacrolimus.

Mifepriston: NSAIDs should not be used for 8-12 days after using Mifepriston, NSAIDs can reduce Mifepriston effect

Cavalry:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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