A.T Loratadin 10 Treatment of allergic rhinitis, allergic conjunctivitis (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Loratadine

Ingredient

Composition information	Content
Loratadine	10mg

Uses

indications

A.T Loratadin 10 drugs are indicated in the following cases:

Allergic rhinitis such as sneezing, nasal water, itchy nose. And there is no soothing effect on the central nervous system. Loratadin belongs to the second generation H1 antagonistic drug group (unsafe).

Loratadine has the effect of gently reducing the symptoms of rhinitis and allergic conjunctivitis due to histamine release. Loratadine also has anti -itching and urticaria effects related to histamines. However, Loratadin has no protection or clinical assistance for severe histamine release as anaphylaxis. In that case, the main treatment is adrenalin and corticosteroids.

Antihistamine drugs do not play a role in asthma treatment.

The second -generation H1 antagonists (unsafe) such as Terfenadin, Astemizol, Loratadin, non -distributed into the brain, when taking the drug in normal doses. Therefore, Loratadin has no sedative effect, contrary to the sedative side effects of the first -generation antihistamine drugs.

To treat allergic rhinitis and urticaria, Loratadin has a faster effect than astemizol and works like azatadin, Cetirizin, Clopheniramine, Clemastin, Terfenadin and Mequitazin. Loratadine has a frequency of side effects, especially for the central nervous system, lower than other second -generation antihistamine drugs. Therefore, Loratadin used once a day, quickly, especially without sedative effects, is the first choice to treat allergic rhinitis or allergic urticaria. Antihistamine drugs do not work to treat the cause but only help to mild symptoms. Allergic rhinitis may be chronic and recurring. For successful treatment, it is often necessary to take long -term antihistamines and interrupts. Also use other drugs such as glucocorticoids used in inhalation lines, and prolonged use.

can combine loratadin with pseudoephedrin hydrochloride to gently reduce the symptoms of nasal congestion in the treatment of allergic rhinitis with nasal congestion.

Dynamic pharmacokinetics

Loratadin quickly absorbed after drinking. The average plasma peak concentration of loratadine and its active metabolites (descarboethoxyloratadine) corresponds to 1.5 and 3.7 hours. 97% Loratadine binds to plasma proteins. Loratadin's half -life is 17 hours and of Descarboethoxyloratadin is 19 hours. Half of the drug of the drug transforms a lot between individuals, is not affected by blood urea, increasing in the elderly and people with cirrhosis.

The clearance of the drug is 57 - 142 ml/min/kg and is not affected by blood urea but decreased in patients with cirrhosis. The distribution of the drug is 80 - 120 liters/kg. Loratadin metabolizes a lot when the liver is first passed by the liver by the microsom cytochrom P450 enzyme system; Loratadin mainly converted into carbohoxyloratadin, which is a pharmaceutical effect.

About 80% of the total dose of loratadin secreted the urine and stool equally, in the form of metabolites, within 10 days. After taking Loratadin, the antihistamine effect of the drug appears within 1-4 hours, reaching maximum after 8 - 12 hours, and lasting more than 24 hours.

The concentration of loratadin and descarboethyloratadin reaches a stable state in most patients around the fifth day of medication.

Before taking A.T Loratadin 10 Treatment of allergic rhinitis, allergic conjunctivitis (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults and children over 12 years old

Take 1 capsule per day.

Children from 2 -12 years old

Body weight> 30 kg: Take 1 capsule per day.

Body weight

Safe and effective when using loratadin for children under 2 years of age has not been determined.

People with severe liver or kidney failure (Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In children there are expressions of the tower, brushing the chest.

Treatment of Loratadin overdose is usually symptomatic and supportive treatment. Causes vomiting with ipeca syrup, activated carbon. If vomiting is ineffective or contraindicated (patients with fainting, convulsions, lack of vomiting reflexes), the stomach can be carried out with 0.9% sodium chloride solution and intubation to prevent the inhalation of gastric juice.

Loratadin is not eliminated by a hemorrhage.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using A.T Loratadin 10, you may experience unwanted effects (ADR).

The severe ventricular arrhythmia occurred when treated with some 2nd generation H1 histamine anti -receptors. That did not appear when treated with loratadine. When using loratadin at a dose greater than 10 mg daily, the following side effects may occur:

Common, ADR> 1/100

Neurology: headache.

Digestive: dry mouth.

Uncommon, 1/1000

Neurology: dizziness.

Respiratory: dry nose and sneezing.

Other: conjunctivitis.

Rare, ADR

Neurology: depression.

Cardiovascular: Heart beat fast, tachycardia on ventricular, brushing chest.

Digestive: nausea.

Metabolism: abnormal liver function, irregular menstruation.

Other: Ban, urticaria, and anaphylaxis.

Instructions on how to handle ADR

Use Loratadin with the lowest doses that are effective.

Notice immediately to the doctor the unwanted effects encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

A.T Loratadin 10 is contraindicated in cases of sensitivity to loratadin or other ingredients of the drug.

Be cautious when using

Caution with patients with liver failure.

Safe and effective when using loratadin for children under 2 years of age has not been determined.

When using Loratadin, there is a risk of dry mouth, especially in the elderly, and an increased risk of tooth decay. Therefore, clean oral hygiene when using loratadin.

The ability to drive and operate machinery

A.T Loratadin 10 does not cause drowsiness. However, it can cause unwanted effects such as headache, dizziness, depression and nausea. Therefore, it is best not to use loratadin while participating in these activities.

Pregnancy

There are no complete studies and good tests for the use of loratadin during pregnancy. Therefore, only loratadine is used during pregnancy when necessary, with low doses and in a short time.

breastfeeding period

Loratadin and metabolites Descarboethoxyloratadin are secreted into breast milk. Therefore, only loratadine for pregnant and lactating women when needed, with low doses and in a short time.

Drug interaction

simultaneous treatment of loratadine and cimetidine leads to an increase in loratadine concentration in plasma 60%, due to cimetidine inhibiting metabolic of loratadin. This has no clinical manifestations.

Simultaneous treatment of Loratadine and Ketoconazole leads to an increase in loratadine levels in plasma 3 times, due to CYP3A4 inhibitors. That has no clinical manifestations because Loratadin has a broad treatment index.

Concomitance of Loratadin and erythromycin leads to increased plasma Loratadin levels. AUC (area under the curve of the background over time) of Loratadin increases by 40% and the AUC of Descarboethoxy Loratadin increases an average of 46% compared to single Loratadin treatment. On the center of the center, there is no change in the QTC range. Clinically, there is no manifestation of loratadin's safety change and there is no notice of sedative effects or fainting phenomenon when treating these two drugs simultaneously.

In tests: 48 hours should be stopped before conducting skin tests.

Storage

Store in a dry place, temperature

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