A.T Olanzapine Odt 10mg tablets An Thien treat schizophrenia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Olanzapine

Ingredient

Composition information	Content
Olanzapine	10mg

Uses

Indications

Olanzapine ODT 10mg drug is indicated in the following cases:

Treatment

schizophrenia, bipolar disease: the acute acute or mixture, bipolar disease cycle quickly, aging acute due to schizophrenia or bipolar disease.

Mental mental treatment in adults and children aged 12-18 (under the close supervision of a specialist).

Pharmacy

olanzapine is a neuroleptic (anti -psychotic drug) typical (second generation) and is the substance of dibenzodiazepin. The drug has many other pharmacological properties different from the typical anti -psychotic drugs, which are the substance of phenothiazin or butyrophenon such as less causing extracurricular syndrome, less prolactin secretion, less dysplasia when treated for prolonged treatment and effectively effective on both positive, negative and inhibitors of schizophrenia.

Olanzapine's anti -psychotic effect has a complex mechanism and has not been completely clarified. This mechanism is associated with the antagonism of the drug in Serotonin tube 2 (5-HT2A, 5-HT2C), tube 3 (5-HT3), tube 6 (5-HT6) and dopamine in the central nervous system. Olanzapine has the effect of inhibiting and reducing the response (negative air conditioner) for the 5-HT2A receptor, related to the anti-revolt effect of the drug. In addition, olanzapine also stabilizes the temperament due to partial inhibition of D2 receptors of Dopamine.

olanzapine also has antagonistic effects on Muscarin receptors (M1, M2, M3, M4 and M5). The anti -cholinergic effect of the drug explains the risk of reducing the occurrence of extracurricular syndrome, on the other hand, related to some other unwanted effects of olanzapine. Olanzapine also has Hiatamin's H1 receptor antagonist and Alpha-1 Adrenergic receptor. This effect is related to the risk of chicken sleep, hypotension posture when using olanzapine.

pharmacokinetic

absorption

After drinking, olanzapine absorbs quickly and almost completely through the digestive tract, but due to the first metabolic in the liver, the oral use only reaches 60%. Food does not affect the absorption of drugs. The concentration of medication in the blood reaches maximum of about 6 hours (ranging from 5 - 8 hours) after taking the drug. The concentration of drugs in plasma reaches a stable state after 7-10 days of repeated dose. Olanzapine plasma concentrations change between individuals, depending on age, gender and smoking or not. Blood medication concentration in women is about 30-40% higher than men. The concentration of olanzapine treatment in plasma has not been clearly defined. The correlation between blood concentration and effectiveness and toxicity of olanzapine has not been established.

Distribution

olanzapine is distributed quickly and much to tissues, including central nerves. The distribution volume is about 1000L. The ratio of plasma protein is about 93%, mainly linked to albumin and Alpha-1 Glycoprotein. Olanzapine and glucuronid conjugate metabolites pass the placenta and are exempted into breast milk. The amount of drug stabilized in babies is about 1.8% of the mother's dose. In addition, the peak concentration in breast milk is about 5.2 hours slower after reaching the peak concentration in the mother's plasma.

Metabolism

olanzapine is metabolized in the liver before eliminating mainly through CYP1A2, a small part through CYP2D6, then conjugated with glucyronic acid. The two main metabolites are 4’-N-Demethyl olazapin and 10-N-Glucuronid no longer active.

Elimination

After drinking, the plasma sale time of olanzapine is about 30 hours (ranging from 21 to 54 hours). The selling time increased by about 1.5 times in the elderly. Olanzapine's clearance increased by about 40% in smokers compared to non -smokers and decreased by about 30% in women compared to men. About 57% of the drug is eliminated into the urine and 30% in the stool, mainly in the form of metabolites, a small part (7%) in the form of intact. The pharmacokinetics of the drug does not change much in patients with renal failure.

Before taking A.T Olanzapine Odt 10mg tablets An Thien treat schizophrenia (10 blisters x 10 tablets)

How to use

olanzapine is used orally, can be taken at meals or away from meals.

Should only be separated from the blister right before use, put them immediately in the mouth to be dissolved with saliva then swallow with water or do not need to use water. In case of only half of the tablet, the rest must be removed, not kept for use later.

Patients with long -lasting drowsiness may use daily dose in the evening before going to bed.

Olanzapine's dose must be carefully corrected on each patient and the lowest dose use effectively. Dosage should be gradually increased and divided into daily doses at the beginning of treatment to minimize unwanted effects.

Dosage

Adults over 18 years old

schizophrenia

Starting dose of 5 - 10mg, usually taken 1 time/day. The dose can be increased by about 5mg/day for 5-7 days to the destination of 10mg/day. The dose adjustment in the later stage usually must be less than 7 days apart, increasing or decreasing 5mg daily to the maximum dosage recommended 20mg/day.

Maintenance dose: 10 - 20mg/day, drink 1 time.

Note: The dose of 30 - 50mg/day has been used, but the dose is over 10mg/day does not show greater efficiency. The safety and effectiveness of the dose above 20mg/day have not been determined.

Optimal treatment time has not been determined. Patients responding to olanzapine need to continue treating (if necessary and tolerant drugs) but with the lowest dose effective.

For patients with depression, easy to lower blood pressure is very sensitive to the effects of olanzapine or patients with slow metabolic olinzapine (women do not smoke or patients over 65 years old), the recommended starting dose is 5mg/day.

Dipolot disease, acute or mixed manual wave

Single therapy: Starting 10 - 15mg/day, 1 time. Can increase the dose of 5mg/day apart not less than 24 hours.

Maintenance dose: 5 - 20mg/day. The maximum recommended dose is 20mg/day.

Combined therapy (with lithium or valproat): start 10mg/day, drink once. Dosage can fluctuate within 5 - 20mg/day.

Note: olanzapine can be used in combination with fluoxetin to treat the exacerbation with the starting dose of olanzapine 6mg, fluoxetin 25mg. In this case, it is necessary to switch to the form of a fixed dose of olanzapine and fluoxetin.

Children 13 - 17 years old

schizophrenia

The starting dose of 2.5 - 5mg/day, taken 1 time. Dosage 10mg/day.

Can adjust or decrease the dose 2.5mg or 5mg.

Maximum dose of 20mg/day.

Dipect disease

The starting dose of 2.5 - 5mg/day, taken 1 time. Dosage 10mg/day.

can increase or decrease the dose of 2.5mg or 5mg. Maximum dose of 20mg/day.

kidney failure

No need to adjust the dose for patients with renal failure.

liver failure

Need to adjust the dose for patients with liver failure, but no specific dose correction recommendations are given, tight monitoring of patients.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Overdose is usually observed at a dose of over 200mg. Symptoms usually appear within 1-2 hours, maximum effect of 4-6 hours after taking the drug: agitation, tachycardia, cholinergic resistance, magnetic stretching, extrasic symptoms, muscle spasms, salivation increases, consciousness from sedative to coma, sometimes cardiac arrest and respiratory arrest, fast -paced pacemosis, hypertension, hypertension, hypertension, hypertension, hypertension, hypertension, hypertension, hypertension. both posture hypotension).

Handling

There is no specific antidote, mainly symptomatic treatment, support for support, sustaining intravenous pathway accompanied by tightening cardiovascular function and survival signs:

Gastrointestinal lavage along with taking activated carbon with sorbitol to remove and prevent the absorption of the remaining drug in the digestive tract.

Maintain support and oxygen therapy.

Treatment of hypotension and circulatory failure with intravenous solutions and vasodilators (noradrenalin, phenylephrin) but avoid dopamine and adrenalin.

Control arrhythmia by appropriate treatments, extending the QRS interval on the electrocardiogram that can be adjusted by Bicarbonate infusion.

Acute surgeon syndrome can be treated with cholinergic drugs (diphenhydramin, atropin). Physostigmin or benzodiazepine can be used if there is a severe and confused manifestation in patients with severe cholinergic poisoning with a short QRS complex on the center of electrolyte.

Dialysis and peritoneal jurisdiction plays a very limited role in the treatment of olanzapine acute poisoning.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Olanzapine ODT 10mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous: Sleeping chicken, pagoda syndrome, insomnia, dizziness, pronunciation disorders, fever, nightmares, refreshment, forgetting, manic.

digestive: indigestion, constipation, weight gain, dry mouth, nausea, vomiting, increased cravings.

liver: increase ALT.

muscle - bone: weak muscle, tremor, fall (especially in the elderly).

Cardiovascular: lower blood pressure, tachycardia, peripheral edema, chest pain. skin: burns.

Endocrine, metabolism: hyperkemia, hyperkemia, hyperglycemia, urinary hemorrhage.

Eye: Reduction of vision, conjunctivitis.

Uncommon, 1/1000

leukopenia, neutropenia, slow rhythm, extending the QT range on the center of electrocardiogram, increasing sensitivity to light, epilepsy.

Rare, ADR

Pancreatitis, malignant neuron syndrome (hyperthermia, muscle spasticity, mental status changes with autonomous nervous system disorders: heart rate and blood pressure unstable).

Instructions on how to handle ADR

Stop drugs in the event of manifestations of malignant neuron sense. Treatment of positive support and closely monitor patients, need to be careful when reusing olanzapine for patients after the appearance of malignant neurolithic syndrome, so the choice of less drugs causing this syndrome and weight weight slowly for patients.

Stop drugs or reduce olanzapine dose if late movement disorders during use.

Dosage or medication 1 time/day when going to bed if drowsiness appears during the use of olanzapine.

Use medication or non -drug treatments to adjust and then lipid disorders if appearing during olanzapine treatment. It is possible to consider using replacement with other neuroleptic drugs that are less affected on lipid chemistry such as Risperidon, Ziprasidon or Aripiprazol.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Olanzapine ODT 10MG drug is contraindicated in the following cases:

breastfeeding women.

Hypersensitivity to olanzapine.

Precautions when using

in children, although the effect and safety of olanzapine are not yet established, olanzapine has been used effectively in schizophrenic control at this age group. The drug is indicated for schizophrenic treatment, coordinating the treatment for patients from 12 - 18 years old under the close supervision of a specialist.

Caution for elderly patients with mental disorders associated with dementia due to the risk of increased mortality rate, mainly due to cardiovascular causes (heart failure, sudden death) or bacterial infection (pneumonia).

Children from 13 - 17 years old tend to gain weight and the risk of increasing blood lipids more than adults. Therefore, it is necessary to evaluate the risk of long -term and detailed treatment plan before using olanzapine.

Be cautious when using olanzapine for benign prostatic hypertrophic people, narrow -angle glaucom or bowel history due to the drug's anti -cholinergic effect.

It is necessary to assess body temperature and caution for patients who work severe physical work, dehydration, being treated with other anti -cholinergic drugs due to the risk of increasing the body's body temperature.

Be cautious when using olanzapine for people with heart disease, cerebrovascular disease or diseases that can cause hypotension (dehydration, decrease in circulatory volume, which are being treated with anti -hypertension drugs) due to the risk of increased posture of blood pressure with slow rhythms, fainting and stopping sinus nodes.

Be cautious when using olanzapine for diabetes patients, patients with high blood sugar (hungry sugar from 100 - 126mg/decadite) due to the risk of hyperglycemia, even uncontrolled even after the drug is stopped. Need to monitor blood sugar during treatment.

Be cautious with the elderly, especially women due to the risk of increased movement disorders. In case of this disorder, it is necessary to consider the ability to stop the drug.

Caution for patients with symptoms of liver function impairment, patients with diseases that affect liver function or are being treated with toxic drugs to the liver, need periodic transamine concentration during the use of olanzapine for these objects.

Be cautious when using olanzapine for people with a history of epilepsy, head injury or being treated with drugs that can reduce epilepsy threshold due to seizures depending on the doses that may occur during the use of olanzapine.

This drug contains lactose. Patients with rare genetic diseases such as galactose intolerance, lapp lactase deficiency, or glucose absorption disorders - galactose should not use this drug.

The ability to drive and operate machinery

olanzapine can reduce concentration due to the sedative effect of the drug, avoiding use for people who are driving or operating machinery.

Pregnancy

Although animals do not show the effects of olanzapine in pregnancy, due to lack of human data, it is necessary to be cautious when used for pregnant women and need risk - benefits before starting treatment for this object.

Breastfeeding period

olanzapine which is exported into milk can cause central neurological inhibiting effects in breastfed babies. Therefore, it is necessary to avoid using olanzapine for breastfeeding women or not breastfeeding when required to treat the mother.

Drug interaction

Avoid coordination

Do not coordinate olanzapine with:

levomethadyl due to increased risk of toxicity on the heart (extending the QT, twisting, cardiac arrest).

metoclopramide due to an increase in the risk of outsurers of extracurricular syndrome, malignant neuron syndrome.

Increases the effect and toxicity of olanzapine:

Simultaneous use of olanzapine with central neurological inhibitors such as alcohol, benzodiazepine derivatives increase the effect of lowering the posture effect of olanzapine.

CYP450 inhibitors (caffeine, cimetidin, erythromycin, ciprofloxacin, quinidine, some antidepressants such as fluvoxamine) increase blood levels can lead to increased effects and toxicity of olanzapine.

Do not use dopamine, adrenalin or medications similar to the beta receptor in patients being treated with olanzapine because it can worsen the antihypertensive effect of olanzapine.

Reduce the effects of olanzapine: CYP450 induction drugs (phenobarbital, carbamazepin, phenytoin, rifampicin, omeprazol, nicotine) reduce the concentration of olanzapine in blood.

Increases the effects and toxicity of some other drugs: olanzapine increases the effects of anti -cholinergic drugs (constipation, dry mouth, urinary retention, sedation, visual disorders), increasing the effect of lowering blood pressure of anti -hypertension drugs.

Reduce the effect and toxicity of some other drugs: olanzapine can reduce the effects of Parkinson's medications.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.