Atasart tablets 16mg Getz treat hypertension (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Candesartan
Ingredient High blood pressure

Ingredient

Composition information	Content
Candesartan	16mg

Uses

indications

Atasart Tablets are used in the following cases:

Treatment of hypertension in adults.

Treatment of hypertension in children and adolescents from 6 to under 18 years old.

Treatment of hypertension in adults of heart failure and left ventricular dysfunction (left ventricular blood emulsion fraction ≤ 40%) When the medication is inhibited inhibitors (ACE) is intolerant or additional treatment for enzyme inhibitors transferred in patients with symptoms, although optimal treatment, when mineralocorticoid receptor counterparts are not tolerated.

Pharmacokinus

Candesartan is an angiotensin II receptor antagonist. The medication prevents vascular effects and causes Aldosteron secretion of angiotensin II by selecting the cohesion of Angiotensin II with AT1 receptor of many tissues (blood vessel smooth muscles, adrenal glands). Therefore, its impact depends on the synthesis of angiotensin II.

The AT2 receptor is also found in many tissues but has not yet been thought to have a role in keeping the cardiovascular system balance. Candesartan has more similarities with the AT1 receptor than AT2.

The impact of the Renin - Angiotensin closing system with enzyme inhibitors, Angiotensin II biosynthesis inhibits from angiotensin I, widely used in the treatment of hypertension. The enzyme inhibitor also inhibits Bradykinin. Candesartan does not inhibit the transfer enzyme (Kininase II) so it does not affect the response of Bradykinin. Candesartan does not bind or blockade other hormone receptors or important ion channels in the cardiovascular regulation.

Angiotensin II receptor collar inhibits the negative feedback mechanism of Angiotensin II on Renin secretion, however, the increase in plasma and angiotensin II concentration in the circulation does not exceed the effects of Candesartan on blood pressure.

pharmacokinetics

absorption:

Candesartan CilexETIL is absorbed quickly and fully converted by hydrolyzing ester while absorbing from the digestive tube into Candesartan.The absolute bioavailability of Candesartan is about 15%. Plasma peak concentration is achieved after taking 3-4 hours. Fat -rich foods do not affect the bioavailability of the drug.

Distribution:

After using single dose, repeat, pharmacokinetics of linear cantesartan with a dose of up to 32 mg of Candesartan Cilexetil. Candesartan and its inactive metabolites are not accumulated in the body when repeating the dose once a day.

The distribution of Candesartan's distribution is 0.13 l/kg. The ratio of cohesion with plasma protein (> 99%), the drug does not absorb into red blood cells.

Metabolism - excretion:

Candesartan metabolizes a small part of the liver through the O - Deethyl path turns into an inactive metabolite.

About 26% of oral dosage is excreted in the form of unchanged urine. The total clearance of plasma in plasma is 0.37 ml/min/kg, glomerular filtration is 0.19 ml/min/kg. The sale time of the drug is about 9 hours.

Before taking Atasart tablets 16mg Getz treat hypertension (4 blisters x 7 tablets)

How to use

candesartan should be taken once a day, with or not used with food.

Dosage

Hypertension treatment:

The starting dose and the normal maintenance dose are 8 mg/day. Most of the hypotension effects achieved within 4 weeks.

When the blood pressure is not controlled, the dose may increase to 16 mg/day, up to 32 mg/day. Dose adjustment depending on the response to each patient.

Candesartan may be prescribed with other blood pressure medications.

Elderly patients:

No dose adjustment.

Patients with reduced intravascular volume:

The starting dose of 4 mg in patients is at risk of hypotension, especially in patients with decreased volume of fluid.

Patients with renal failure:

The starting dose of 4 mg in patients with renal impairment and patients with hemorrhage. Adjust the dose based on response. Little data on patients with severe kidney failure or end -stage (Clcreatinin

Patients with liver failure:

The starting dose of 4 mg/day in patients with mild to medium liver failure. Adjust the dose based on response. Contraindicated in patients with severe liver failure and/or cholestasis.

Black skin patient:

Candesartan's hypotension is less clear in black skin patients than other patients. Need to regularly increase the dose and indicate simultaneously with other drugs to control blood pressure.

Children and teenagers from 6 to under 18 years old:

Starting dose 4 mg/day/day.

Children

can increase to up to 8 mg/day if necessary.

Children ≥ 50 kg:

can increase to 8 mg/day and then 16 mg/day if necessary.

Candesartan has not been studied in children with GFR

Black skin:

Do not recommend children from 1 to under 6 years old.

Contraindicated for children under 1 year of age.

heart failure treatment:

The normal starting dose of Candesartan is 4 mg/day. Increase the target dose 32 mg/day/day or the highest tolerance (double the dose for at least 2 weeks).

Review patients with heart failure is always accompanied by kidney function assessment, monitoring creatinine and blood potassium.

Candesartan can be treated with other heart failure drugs (ACE inhibitors, β blockers, diuretics, digitalis or the combination form of these drugs). Candesartan should not be coordinated with ACE inhibitors, potassium diuretics and should only be considered after evaluating the benefits and potential risks.

Elderly patients, patients decreased in internal fluid volume, renal failure, mild to moderate liver failure:

No starting dose.

Pediatric patients are new to 18 years old:

No report.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

If signs of hypotension, immediately apply supportive therapies. Candesartan cannot be excluded by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Common

Respiratory infections;

body weakness, fever;

anxiety, neurasthenia;

Difficulty;

Angina, myocardial infarction, angioedema.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Hypersensitivity to any ingredients of the drug.

Pregnant women phase 2 and 3 of pregnancy.

Patients with severe liver failure and/or cholestasis.

Concomitance Candesartan with Aliskiren containing drugs in diabetes patients or renal failure (GFR

Pediatric patients under 1 year of age.

Caution when used

In patients with blood vessels and renal function depends mainly on the operation of the Renin - Angiotensin - ALDosteron system (patients with severe congestive or simultaneous heart disease, kidney stenosis), treatment with other drugs that affect this system can cause acute hypotension, hyperkemop

Excessive hypoglycemia in patients with ischemia, ischemic heart, ischemia can cause myocardial infarction or stroke.

For children with impaired intravascular volume (treatment with diuretics, impaired renal function), Candesartan treatment should start under strict medical supervision and lower starting dose.

When using Candesartan in patients with hypertension with renal failure, periodic monitoring of blood potassium and serum creatinine. Dose adjustment and blood pressure monitoring.

Use a combination of Candesartan or Aliskiren and ACE inhibitors that increase the risk of side effects (hypotension, hyperkalemia, impaired renal function). Regular monitoring and monitoring of kidney function, blood pressure, and electrolyte if you really need to combine these drugs. Candesartan should not be combined and ACE inhibitors for patients with diabetic kidney disease.

During blood decomposition, blood pressure may be especially sensitive to the drug. Candesartan dose should be adjusted and blood pressure monitoring.

The drug can increase blood urea and serum creatinine in patients with narrowed kidney stenosis on both sides or 1 side.

Can hypotension during anesthesia and surgery in patients using Candesartan.

Particularly cautious when used in patients with aortic stenosis, 2 -leaf valve stenosis, hypertrophic heart disease.

It is not recommended to use candesartan in patients with primary aldosteron syndrome.

For patients with heart failure treated with candesartan, blood potassium can be lowered. Regular monitoring of blood potassium.

The ability to drive and operate machinery

No research. It should be noted that occasionally occurs dizziness and fatigue during the medication period.

Pregnancy

do not recommend using Candesartan for the first 3 months of pregnancy. Contraindicated in the last 6 months of pregnancy.

In women who are 3 months pregnant between and at the end of pregnancy, the drug can cause damage and death for the fetus. When you are pregnant, you must stop taking the drug as soon as possible.

Breastfeeding period

It is unknown whether Candesartan is excreted through breast milk or not. Because strong reactions on children's emulsion, Candesartan should not be used while breastfeeding.

Drug interaction

Candesartan is negligible by the cytochrome P450 enzyme system and at the non -fermentation treatment dose P450, so no interaction with inhibited or metabolic drugs by these enzymes.

Angiotensin transfer and receptor blockers (including candesartan) may increase the concentration of potassium in the blood. Be cautious when taking Candesartan with drugs that can increase blood potassium levels such as spironolacton, potassium, heparin, co -trimoxazol.

Used in combination with lithium and candesartan to increase lithium concentration.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

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