Atenolol Stada 50 mg stada treatment for hypertension, angina (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Atenolol
Ingredient Stada

Ingredient

Composition information	Content
Atenolol	50mg

Uses

indication

atenolol is indicated in the treatment of hypertension, stable chronic angina, ventricular tachycardia, early intervention at the acute phase of myocardial infarction and long -term treatment for preventive disease after acute myocardial infarction.

Pharmacokology

Atenolol is a Beta-adrenergic receptor blocker, which is relatively selective with β1 (selected for the heart) without intrinsic sympathetic and membrane stability. With the effect of reducing sympathetic tone, Atenolol reduces heart rate, reduces heart contraction, reduces the speed of the atrial transcription and reduces the lenin activity in plasma. Atenolol can increase smooth muscle tone by inhibiting receptors β2.

Dynamic pharmacokinetics

about 50% of atenolol's oral dosage are absorbed through the gastrointestinal tract. Although Atenolol is not metabolized for the first time through the liver, the whole body uses only about 50%. The time to reach the peak concentration in plasma is 2-4 hours. Plasma protein binding rate is about 3%; Relative distribution volume is 0.7 l/kg.

Atenolol is very much metabolic and does not form clinical and active metabolites. About 90% of Atenolol in the circulation are eliminated in the form of unchanged with the kidneys within 48 hours. Atenolol's sale time is 6 -10 hours in normal kidney function patients and can increase up to 140 hours in end -stage renal failure patients.

Before taking Atenolol Stada 50 mg stada treatment for hypertension, angina (10 blisters x 10 tablets)

How to use

atenolol 50 mg is used by oral before meals.

Dosage

Hypertension

Atenolol's common starting dose in adults is 25 - 50 mg x 1 time/day. Atenolol's adequate hypotension effect is achieved after 1-2 weeks. The dose can be increased to 100 mg once a day to achieve optimal response. Increasing atenolol dose above 100 mg/day usually does not improve blood pressure control.

Angina

For the treatment of chronic stable angina, Atenolol's starting dose in adults is 50 mg x 1 time/day. If not reached optimal response within 1 week, the dose should be increased to 100 mg x 1 time/day.

arrhythmia

After controlled by Atenolol intravenously, the appropriate maintenance dose is 50 - 100 mg/day, used 1 time/day.

Early treatment of acute myocardial infarction

Adult dose: 10 minutes, 12 hours then take over 50 mg, continue to drink for 6-9 days with a dose of 100 mg/day, take 1 time or divide 2 times. Stop Atenolol if the patient has a slow heart, hypotension or any unwanted effect of the drug.

Patients with renal failure

Should reduce the dose of Atenolol in patients with renal impairment, based on creatinine clearance (cc) below:

cc 15 - 35 ml/minute every 1.73 m2: Atenolol's maximum oral dose is recommended as 50 mg/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Symptoms of overdose may include slow heart rate, hypotension, acute heart failure and bronchospasm.

Handling

General treatment includes: closely monitoring, treatment at the special care room; conduct stomach lavage; use activated carbon and laxative to prevent the absorption of the drug while still in the digestive tract; Use plasma or plasma replacement to treat hypotension and shock. Can consider conducting hemorrhage or hemolytic transmission.

Excessive slow heart rate can be treated with Atropin 1 - 2 mg intravenously and/or using a pacemaker. If necessary, intravenously (bolus) can add 10 mg of glucagon. If necessary, it is possible to repeat or intravenously glucagon 1 - 10 mg/hour. If not responded to glucagon occurs or if there is no glucagon available, intravenously can be stimulated as a beta receptor like Dobutamin 2.5 - 10 mcg/kg/min.

Because Dobutamin has a muscle contraction effect, it can also be used to treat hypotension and acute heart failure. These doses may not be enough to regulate the heart effect of the beta receptor blocker if an overdose of a large amount of drug. Therefore, it is necessary to increase the dose of dobutamin if necessary to achieve the desire depending on the patient's clinical condition.

Bronchospasm can be recovered with bronchodilators.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Atenolol 50, you may experience unwanted effects (ADR).

Unwanted effects related to pharmacological effects and dosage dependence of the drug. The most common unwanted effect is fatigue including muscle weakness, accounting for about 0.5 - 5% of patients taking the drug.

Common, ADR> 1/100

Systemic body: Weakness, fatigue, cold and chills of the limbs.

Sleep disorders, sex reduction.

Rare, ADR

Systemic: Dizziness, headache Add psoriasis, hemorrhage.

Eyes: dry eyes, visual disorders.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Atenolol 50 drug contraindicated in the following cases:

Metabolic acid infection.

Hypotension.

Severe peripheral peripheral disorders.

Severe asthma.

Chronic obstructive pulmonary disease (COPD).

Chrome -preferred cells have not been treated.

Patients with slow sinus rhythms (

Collaborate with Verapamil.

Be cautious when using

should not stop using beta receptor blockers suddenly.

Special monitoring of treatment carefully in the following cases:

Patients with asthma or a history of airway obstruction.

Patients with diabetes with high blood sugar levels (due to the risk of serious hypoglycemia).

Patients under strict diet for a long time and patients who have exertion activity (due to the risk of serious hypoglycemia).

Patients with chrome cell tumors (adrenal tumors; have been indicated with previous alpha blockers).

Patients with impaired renal function.

Beta receptor blockers should only be used after a careful consideration between benefits/risks in patients with a history or a family history of psoriasis.

Beta receptor blockers can increase sensitivity to primitive allergies and increase the severity of anaphylactic reactions. Therefore, beta receptor blockers should only be used if it is really necessary in patients with a history of severe sensitivity reactions and patients using specific sensitivity reduction therapy (due to the risk of serious reactions).

The use of Atenolol can give positive results in doping tests. It is unknown for the consequences of health when using Atenolol as a stimulant. Do not exclude heavy risks for health.

Patients with rare genetic galactose intolerance, Lapp lactase deficiency or malposure - galactose should not be used atenolol.

The ability to drive and operate machinery

Patients using the drug must be monitored regularly. Different reactions in each person can change alertness as the degree of driving ability, operating machinery or working without sure protection. Pay special attention when starting therapy, when increasing the dose or changing drugs or when taking alcohol at the same time.

pregnancy

atenolol through the placenta fence and appear in the blood of the umbilical cord. No studies have been conducted on the use of Atenolol in the first 3 months of pregnancy and cannot exclude the possibility of damage to the fetus. Atenolol has been used under close monitoring in the treatment of hypertension in the last 3 months of pregnancy. Use Atenolol for pregnant women to treat hypertension from mild to medium related to the fetal reduction.

Using Atenolol for women who are or is likely to be pregnant needs to consider the benefits and risks, especially in the first quarter and the second quarter of pregnancy, because in general, the beta blockers are associated with reducing placental perfusion that can lead to pregnancy in the uterus and premature birth.

breastfeeding period

Atenolol excreted breast milk at a rate of 1.5 - 6.8 times higher than the concentration of drugs in the mother's plasma. There have been notifications about the harmful effects of breastfed children when the mother uses Atenolol, such as slow heart rate or hypoglycemia of clinical significance. Premature babies, or kidney failure can be susceptible to unwanted effects. Therefore, should not use Atenolol for nursing mothers.

Drug interaction

The following interactions are mentioned when used at the same time atenolol with:

Anti -blood pressure, diuretics, vasodilators, 3 -round antidepressants, barbiturat, phenothiazin: Increasing the hypotension effect of Atenolol.

Anti -arrhythmia: Increasing heart inhibition effect of Atenolol.

Verapamil or diltiazem antagonists or other anti -arrhythmic drugs (such as disopyramid): lower blood pressure, slow heart rate or arrhythmia that may occur (should monitor patients carefully).

Nifedipine -style calcium antagonists: increase the ability to lower blood pressure and in some separate cases, heart failure can be progressed.

Cardiages, reserpin, alpha-methyldopa, guanfacin, clonidin: slow heart rate, delay the transmission of heart impulses. Stop clonidine suddenly used with Atenolol can seriously cause hypertension. Therefore, when using Clonidin at the same time with Atenolol, Clonidin should not be stopped until not using Atenolol a few days earlier. Then can only reduce clonidin dose slowly.

Oral diabetes treatment, insulin: Atenolol increases hypoglycemic effects. The signs of hypoglycemia, specifically, such as tachycardia and tremor are covered or mitigated. Therefore, regular glycemic examination.

noradrenalin, adrenalin: can cause excessive hypertension.

indomethacin: reduces the hypotension effect of atenolol.

Anesthesia/anesthetics: Increases the impact of hypotension, increases the negative muscle impact (notice to the anesthetic doctor about the use of Atenolol).

Peripheral muscle relaxants (e.g. Succinylcholin Halid, Tubocurarin): Atenolol increases and prolongs the muscle relaxation (notice to the anesthetist about the use of Atenolol).

Storage

Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.