Atenolol Stada 50mg medicine treats hypertension, angina (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Atenolol
Ingredient Psoriasis, high blood pressure, angina

Ingredient

Composition information	Content
Atenolol	50mg

Uses

Indications

Atenolol Stada 50mg 2x15 drugs are indicated in cases of hypertension treatment, chronic angina stable, tachycardia on ventricular, early intervention at the acute phase of myocardial infarction and long -term treatment to prevent cardiocese after heart attack.

Pharmacokology

Atenolol is a beta-adrenergic receptor blocker that has a relatively selective of Beta 1 (selected for the heart) without intrinsic sympathetic and stable nerve activity.

With the effect of reducing sympathetic tone, Atenolol reduces heart rate, reduces heart contraction, reduces the speed of atrial transcription and reduces the lyin activity in plasma.

Atenolol may increase smooth muscle tone by inhibiting beta receptors 2.

pharmacokinetic

absorption

About 50% of Atenolol's oral dose is absorbed through the gastrointestinal tract.

Distribution

Although Atenolol is not first metabolized through the liver, the whole body is only about 50%. The time to reach the peak concentration in plasma is 2-4 hours. Plasma protein binding rate is about 3%; Relative distribution volume is 0.7 l/kg.

Metabolism

Atenolol is very much metabolic and does not form clinical and active metabolites.

Elimination

About 90% Atenolol in the circulation is eliminated in the form of unchanged with the kidneys within 48 hours. Atenolol's sale time is 6-10 hours in normal kidney function patients and can increase up to 140 hours in patients with end -stage renal failure.

Before taking Atenolol Stada 50mg medicine treats hypertension, angina (2 blisters x 15 tablets)

How to use

Atenolol Stada 50mg is used by oral before meals.

Dosage

Hypertension:

Atenolol's common starting dose in adults is 25 - 50 mg x 1 time/day. Atenolol's adequate hypotension effect is achieved after 1-2 weeks. The dose can be increased to 100 mg once a day to achieve optimal response. Increasing atenolol dose above 100 mg/day usually does not improve blood pressure control.

Angina:

For the treatment of chronic stable angina, Atenolol's starting dose in adults is 50mg x 1 time/day. If not reached optimal response within 1 week, the dose should be increased to 100mg x 1 time/day.

arrhythmia:

After controlled by Atenolol intravenously, the appropriate maintenance dose is 50 - 100mg/day, used 1 time/day.

Early treatment of acute myocardial infarction:

Adult dose: 10 minutes inject, 12 hours later drink 50mg, take it next for 6-9 days with a dose of 100mg/day, drink once or divide 2 times. Stop Atenolol if the patient has a slow heart, hypotension or any unwanted effect of the drug.

Patients with renal failure:

Should reduce the dose of Atenolol in patients with renal impairment, based on creatinine clearance (cc) below:

cc 15 - 35 ml/minute every 1.73m2: Atenolol's maximum oral dose is recommended as 50 mg/day.

cc below 15 ml/minute every 1.73m2: 25 mg/day or 50 mg daily.

Patient separating: 25 - 50 mg after each appraisal.

What to do when overdose?

Symptoms of overdose may include slow heart rate, hypotension, acute heart failure and bronchospasm.

Management:

General treatment includes: closely monitoring, treatment at the special care room; conduct stomach lavage; use activated carbon and laxative to prevent the absorption of the drug while still in the digestive tract; Use plasma or plasma replacement to treat hypotension and shock. Can consider conducting hemorrhage or hemolytic transmission.

Excessive slow heart rate can be treated with Atropin 1 - 2 mg intravenously and/or using a pacemaker. If necessary, intravenous (bolus) can be added to 10mg glucagon. If necessary, it is possible to repeat or intravenously glucagon 1 - 10 mg/hour. If not responded to glucagon occurs or if there is no glucagon available, intravenously can be stimulated as a beta receptor like Dobutamin 2.5 - 10 mcg/kg/min.

Because Dobutamin has a muscle contraction effect, it can also be used to treat hypotension and acute heart failure. These doses may not be enough to regulate the heart effect of the beta receptor blocker if an overdose of a large amount of drug. Therefore, it is necessary to increase the dose of dobutamin if necessary to achieve the desire depending on the patient's clinical condition.

Bronchospasm can be recovered with bronchodilators.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Atenolol Stada 50mg 2x15, you may experience unwanted effects (ADR).

Unwanted effects related to pharmacological effects and dosage dependence of the drug. The most common unwanted effect is fatigue including muscle weakness, accounting for about 0.5 - 5% of patients taking the drug.

Common

Body: weak muscles, fatigue, cold and chills.

circulating: Slow heart rate, atrial atrial block II, III and hypotension. digestive: diarrhea, nausea.

Uncommon:

Sleep disorders, sex reduction.

Rare:

Body: Dizziness, headache.

Blood: platelets, leukopenia. circulating: Sacrifice heart failure, atrial block - ventricle, posture hypotension, fainting.

Central nerve: nightmares, hallucinations, depression, anxiety, mental illness.

Skin: Hair loss, skin rash, reaction like psoriasis and worsen psoriasis, hemorrhage.

Eyes: dry eyes, visual disorders.

Warnings

Contraindicated

Metabolic acid infection.

Hypotension.

Severe peripheral peripheral disorders.

Severe asthma.

Chronic obstructive pulmonary disease (COPD).

Chrome -preferred cells have not been treated.

Patients with slow sinus rhythms (

Collaborate with Verapamil.

Caution when using

should not stop using beta receptor blockers suddenly.

Special monitoring of treatment carefully in the following cases:

Patients with asthma or a history of airway obstruction.

Patients with diabetes with high blood sugar levels (due to the risk of serious hypoglycemia).

Patients under strict diet for a long time and patients who have exertion activity (due to the risk of serious hypoglycemia).

Patients with chrome cell tumors (adrenal tumors; have been indicated with previous alpha blockers).

Patients with impaired renal function.

Beta receptor blockers should only be used after a careful consideration between benefits/risks in patients with a history or a family history of psoriasis.

Beta receptor blockers can increase sensitivity to primitive allergies and increase the severity of anaphylactic reactions. Therefore, beta receptor blockers should only be used if it is really necessary in patients with a history of severe sensitivity reactions and patients using specific sensitivity reduction therapy (due to the risk of serious reactions).

The use of Atenolol can give positive results in doping tests. It is unknown for the consequences of health when using Atenolol as a stimulant. Do not exclude heavy risks for health.

Patients with rare genetic galactose intolerance, Lapp lactase deficiency or malposure - galactose should not be used atenolol.

The ability to drive and operate machinery

Patients using the drug must be monitored regularly. Different reactions in each person can change alertness as the degree of driving ability, operating machinery or working without sure protection. Pay special attention when starting therapy, when increasing the dose or changing drugs or when taking alcohol at the same time.

Pregnancy

atenolol through the placenta fence and appear in the blood of the umbilical cord. No studies have been conducted on the use of Atenolol in the first 3 months of pregnancy and cannot exclude the possibility of damage to the fetus. Atenolol has been used under close monitoring in the treatment of hypertension in the last 3 months of pregnancy. Use Atenolol for pregnant women to treat hypertension from mild to medium related to the fetal reduction.

Using Atenolol for women who are or is likely to be pregnant needs to consider the benefits and risks, especially in the first quarter and the second quarter of pregnancy, because in general, the beta blockers are associated with reducing placental perfusion that can lead to pregnancy in the uterus and premature birth.

Breastfeeding period

Atenolol excreted breast milk at a rate of 1.5 - 6.8 times higher than the concentration of drug in the mother's plasma. There have been notifications about the harmful effects of breastfed children when the mother uses Atenolol, such as slow heart rate or hypoglycemia of clinical significance. Premature babies, or kidney failure can be susceptible to unwanted effects. Therefore, should not use Atenolol for nursing mothers.

Medicine interaction

The following interactions are mentioned when using Atenolol simultaneously with:

Anti -hypertension, diuretics, vasodilators, 3 -round antidepressants, barbiturat, phenothiazin:

Increase the hypotension effect of Atenolol.

Anti -arrhyths:

Increased heart inhibition effects of Atenolol.

Verapamil or diltiazem antagonists or other anti -arrhythmic drugs (such as disopyramide):

Hypotension, slow heart rate or arrhythmia may occur (should monitor patients carefully).

Nifedipin -style calcium antagonists:

Increases the likelihood of hypotension and in some separate cases, can progress to heart failure.

Cardiages, reserpine, alpha-methyldopa, guanfacine, clonidine:

Slow heart rate, delay the transmission of heart impulses. Stop clonidine suddenly used with Atenolol can seriously cause hypertension. Therefore, when using Clonidin at the same time with Atenolol should not stop clonidin until not using Atenolol a few days earlier. Then can only reduce clonidin dose slowly.

Drugs for oral diabetes, insulin:

Atenolol increases blood hypoglycemia. The signs of hypoglycemia, specifically, such as tachycardia and tremor are covered or mitigated. Therefore, regular glycemic examination.

noradrenalin, adrenalin:

can cause excessive hypertension.

indomethacin:

Reduce the hypotension effect of Atenolol.

Anesthesia/anesthetics: Increases the impact of hypotension, increases the negative muscle impact (notice to the anesthetic doctor about the use of Atenolol).

Peripheral muscle relaxants (e.g. Succinylcholine Halid, Tubocurarine): Atenolol increases and prolongs the muscle relaxation (notice to the anesthetist about the use of Atenolol).

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

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