ATIGIMIN 1000mg An Thien Pharma oral solution for hypercururia (30 tubes x 10ml)

Dosage form 30 tube box
Specifications Arginin hydrochlorid
Ingredient An Thien Pharmaceutical Joint Stock Company

Ingredient

Thành phần cho 10ml

Composition information	Content
Arginin hydrochlorid	1000mg

Uses

Indications

Atigimin oral solution indicated treatment in the following cases:

Maintain blood ammonia in patients with carbamoyl phosphate deficiency synthetase, ornithin carbamoyl transferase. Support to improve the ability to exercise in people with stable cardiovascular disease. Learning

Pharmacological Group: Endocrine Metabolism - Additional amino acids

ATC code: b05xb01

Arginine is an essential amino acid in the urea process for patients who lack N-acetyl glutamat synthase enzymes (NAGS), Carbamoyl Phosphate Synthase (CPS), Ornithin Transcarbamylase (OTC), ArginininoSuccinat Synthetase (ASSS), ARGININININOSIFINAT. Use Arginine hydrochloride for patients with disorders as above to restore arginine concentrations in the blood and help prevent protein catabolism. The intermediate products of the urea cycle are less toxic and easily eliminate through urine than ammonia and create a selective path for nitrogen elimination process.

arginine increases blood glucose levels. This effect may be directly; The amount of glucose released from the liver is directly associated with the amount of amino acids absorbed. Glycogen prize and new glucose creation can also be through arginine intermediaries stimulating Glucagon release.

Dynamic pharmacokinetics

arginine hydrochloride absorbed well through the digestive tract, the peak concentration in plasma is achieved after about 2 hours. Arginine Hydrochloride combines closely with many biochemical paths. The drug is strongly metabolized in the liver, forming ornithin and urea by hydrating Guanidine under the catalyst of Arginase.

arginine is filtered in glomerular and reabsorbed almost completely in the renal tubules.

Before taking ATIGIMIN 1000mg An Thien Pharma oral solution for hypercururia (30 tubes x 10ml)

How to use

oral solution. Should mix with a little water and drink with the main meal or as soon as the symptoms.

Dosage

Dosage of blood ammonia maintenance in patients with carbamoyl phosphate synthetase, ornithin carbamoyl transferase:

Infants: 100 mg/kg/day, divided 3-4 times.

infant: 100 - 175 mg/kg/time; Use 3-4 times/day, with food, adjust the dose according to the response. Use 3-4 times/day, with food, adjust the dose according to the response.

Adults: Take 3 - 6 g/day.

Adults: Take 6 - 21 g/day, each time not more than 8 g.

Adults: Take 3 - 20 g/day depending on the condition.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Overdose in children can lead to increased metabolism, brain edema or may die. Should determine the degree of shortage and calculate the amount of alkaliogens use.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Pain and bloating, thrombocytopenia, increase in green purple head, increase bun and serum creatinine.

Allergic reactions with manifestations such as red rash, swelling of hands and face, these symptoms will reduce quickly when stopping the drug and using diphenhydramin.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ATIGIMIN solution is contraindicated in the following cases:

Patients allergic to any component of the drug.

Be cautious when using

Because the safety and efficiency in pregnant and lactating women have not been established, the drug should only be used in pregnant and lactating women when really necessary.

Should stop the drug if diarrhea occurs.

Arginine may change the ratio between extracellular and intracellular, plasma potassium levels may increase when taking arginine for patients with kidney disease or urinating.

Arginine contains a high content of metabolic nitrogen, so it should evaluate the impact of high amount of nitrogen on the kidney before starting treatment with arginine.

Arginine does not have the effect of treating hyperactive hyperactive hyperacture caused by organic acid disorders, and should not be used in case of disorder.

Autodity warning

The drug contains sucrose, a patient with rare genetic disorders such as fructose intolerance, glucose - galactose or enzyme -deficient - Isomaltase deficiency should not use this drug.

Sodium benzoat may increase the risk of jaundice and yellow eyes in newborns (4 weeks of age or less).

Sunset Yellow color excipients are at risk of allergic reactions.

Use drugs for women during pregnancy and lactation

Pregnant women

Reproductive studies have been conducted on rabbits and mice at 12 times higher dose for humans and no manifestation of fertility decline or damage to Arginine fetuses. There is no adequate and controlled research on pregnant women.

Because animal reproduction studies are not always forecasted to be met in humans, therefore should not take the drug during pregnancy.

breastfeeding women

Amino acids are excreted into breast milk in very small amounts that cannot be harmful to the baby. However, caution should be cautious when taking medicine in nursing women.

The effect of drugs on driving and operating machinery

There has been no research on the impact of the drug on the ability to drive and operate machinery.

Drug interaction

Insulin concentration in plasma due to arginine stimulation may increase higher by thiazid, xylitol and aminophyllin diuretics.

Using oral diabetes for oral diabetes for a long time can inhibit plasma glucagon response to arginine. When patients who do not tolerate glucose are used for glucose, phenytoin reduces insulin response in plasma with arginine. Hyperbonemia may occur when using Arginine to treat metabolic alkaline infections for patients with new severe liver disease using spironolacton recently.

Cavalry: Due to no studies on the correlation of the drug, do not mix this drug with other drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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