Atilene medicine 2.5mg/5ml An Thien treats respiratory diseases, rhinitis, sneezing, runny nose (100ml)

Dosage form Oral solution
Specifications Box
Ingredient Alimemazin Tartrat

Ingredient

Thành phần cho 5ml

Composition informationContent
Alimemazin Tartrat2.5mg

Uses

indications

Atilene drugs are indicated in the following cases:

  • Treatment of symptoms of allergies: respiratory (rhinitis, sneezing, runny nose), skin (urticaria, itching).

    • Pharmacy

    Pharmacological Group: Histamine H1 receptor antagonist, sedative.

    ATC code: R06AD01.

    Alimemazin is a phenothiazine derivative, has a strong anti -histamine and serotonin resistance, the drug also has a sedative, reducing them, anti -vomiting.

    Alimemazin competes with histamines at H1 histamine receptors, thus having H1 antihydration effect. The drug is against the majority of pharmacological effects of histamine, including urticaria and itching. The peripheral anti -peripheral effect of the drug is relatively weak, but it has been seen in some patients who have used alimemazin (for example: dry mouth, blurred vision, urination, constipation).

    Alimemazin has a sedative effect due to the inhibition of nistamine n - methyltransferase and selects the central histamine secretion receptors simultaneously with the effect on other receptors, especially serotonergic receptors. This effect is also the basis for using alimemazin as a dedicated medicine.

    Alimemazin has anti -vomiting effects. The mechanisms of this effect are not fully known. The anti -vomiting effect may be due to the influence of the medication directly on the chemical sensitivity of the spinal cord, it seems to be due to blocking the dopaminergic receptors in this region.

    Dynamic pharmacokinetics

    Alimemazin quickly absorbed through the gastrointestinal tract after taking 15-20 minutes, the drug works and lasts 6 - 8 hours.

    Selling time is 3.5 - 4 hours; Linking with plasma proteins is 20 - 30%. Alimemazin eliminates the kidneys in the form of sulfoxide metabolites (70 - 80%, after 48 hours). The ratio of metabolites and elimination in the elderly.

    Before taking Atilene medicine 2.5mg/5ml An Thien treats respiratory diseases, rhinitis, sneezing, runny nose (100ml)

    How to use

    Used orally, not for children under 2 years old.

    Dosage

    For 5 ml oral tube specifications:

    Symptomatic treatment of allergies:

  • Adults: Drink 4 tubes/time, 2-3 times a day. The dose of up to 100 mg per day has been used in difficult cases.

    Symptomatic treatment of allergies:

  • Adults: drink 4 packs/time, 2-3 times a day. The dose of up to 100 mg daily has been used in difficult cases.

    Symptomatic treatment of allergies:

  • Adults: each drink 20 ml (measuring with the attached beaker), 2-3 times a day. The dose of up to 100 mg daily has been used in difficult cases.

    Children from 2 - 7 years old: The maximum dose is recommended as 2 mg (about 4 ml (measuring with the attached cup)) for each kilogram of weight within 1-2 hours before surgery.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    Sleep or loss of consciousness, lower blood pressure, increased heart rate, electrocardiogram disorders, hypothermia. Severe serious percussion disorders may occur.

    Treatment:

    If detected early (before 6 hours, after overdose), it is best to wash the stomach. The method of vomiting is almost unused. Can use activated carbon. There is no specific antidote. Need supportive treatment. Body vasodilation can lead to cardiovascular collapse; Improving the legs of the patient can be effective, in severe cases, increasing the volume of circulating by intravenous injection of 0.9% NaCl solution is necessary, the infusion should be warmed before use to avoid serious heat lowering.

    Muscle hygiene agents such as dopamine can be used in case of not resolving cardiovascular collapse by infusion. Often do not use peripheral vasoconstrictions, avoid adrenalin.

    ventricular or erratic tachycardia responds when the body temperature returns to normal and circulating or metabolic disorders are adjusted.

    If continuing or life -threatening, anti -arrhythmia can be used. Avoid using lignoCaine or anti -arrhythmic drugs with prolonged effects.

    When severe central neurological inhibitors need respiratory support. Heavy muscle -hypertonic reactions often respond to processes (5 - 10 mg) or orphenadrin (20 - 40 mg) intramuscular or intravenously. Convulsions need to be treated with intravenous diazepam intravenously.

    Malignant syndrome caused by sedatives should be treated with cooling for patients and can use sodium dantrolen.

    In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

    • Side Effects

    When using Atilene medicine, you may experience unwanted effects (ADR):

    The frequency of unwanted effects depends on the dose and duration of use, on the indication of treatment.

    Common, ADR> 1/100:

  • Body: fatigue, drowsiness, headache, mild dizziness. Dry mouth, dense phlegm.
  • Digestive: Constipation.
  • Blood: granulocytes, leukopenia.
  • circulating: Reducing blood pressure, increasing heart rate.
  • Neurological: Symptoms of foreign tower, Run Parkinson jerk, restlessness, acute muscle disorders, late movement disorders; Dry mouth can harm teeth and enamel; Phenothiazin can reduce seizures in epilepsy.

    Notify the physician the unwanted effects when using the drug.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    ATILENE drugs contraindicated in the following cases:

  • Hypersensitivity to antihistamine. phenothiazin.

    Be cautious when using

    need to be very careful when taking the drug for patients in the following cases:

  • The drug ingredient contains sorbitol and sucrose, patients with fructose intolerant treatment disorders, glucose-galactose absorption disorders or enzyme deficiency sucrose-isomtase should not use this drug. For the elderly, especially when the weather is very hot or very cold because of the risk of increasing or cooling.
  • The drug can extend the qt range on the electrocardiogram.

    The effect of the drug on the ability to drive and operate machinery

    Do not take the drug when driving and/or operate machinery.

    Use drugs for women during pregnancy and nursing mothers

    because the drug through the placenta and breast milk causes symptoms of jaundice, symptoms of extracurricular pulp in babies so do not use drugs for pregnant and lactating women. If you have to take the drug, stop breastfeeding.

    Interactive drug

    The central neurological inhibitor effect will be stronger by: alcohol, Barbituric sleeping pills and other sedatives. Respiratory inhibition also occurred when used in combination with these drugs.

    The hypotension effect of anti-hypertension drugs will increase, especially the alpha-adrenergic receptor blockers increased when used in combination with alimemazine.

    Increase or decrease in plasma concentrations of some drugs, such as propranolol, phenobarbital have been observed but not clinically significant.

    The high dose of alimemazin reduces response to hypoglycemic drugs.

    Adrenalin is not used in patients overdose with alimemazin.

    Alimemazin's

    anti -cholinergic resistance increases when combined with other anti -cholinergic drugs, leading to constipation, heat.

    Alimemazin is against the therapeutic effect of amphetamin, levodopa, clonidin, guanethidin, adrenalin.

    Some drugs that prevent the absorption of alimemazin are antacids, Parkinson, lithium medications.

    • Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

    To be out of reach of children, read the user manual carefully before use.

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