ATOCIB 120mg DHG drugs treat osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Etoricoxib
Ingredient Dysmenorrhea, joint spondylitis, rheumatoid arthritis, chronic pain, acute pain

Ingredient

Composition information	Content
Etoricoxib	120mg

Uses

indications

Atocib drug is indicated in the following cases:

Acute and chronic treatment of signs and symptoms of osteoarthritis (osteoarthritis) and rheumatoid arthritis. Learning

atocib with Etoricoxib active ingredient, is a nonsteroidal anti -inflammatory drug, selective inhibition of cyclooxygenase - 2 (COX - 2), has anti -inflammatory, analgesic, antipyretic effect. Etoricoxib does not inhibit the synthesis of prostaglandin stomach and no effect on platelet function.

Dynamic pharmacokinetics

Etoricoxib is well absorbed from oral. Absolute bioavailability is about 100%. Food does not affect the ability to absorb drugs. The drug is linked to plasma protein about 92%. Etoricoxib is strongly metabolized with

Most Etoricoxib is excreted mainly through metabolism, then through the excretion in the kidneys. Etoricoxib's concentration in a sustainable state is achieved within 7 days of treatment when taking a dose of 120 mg once a day, with an accumulated ratio of nearly 2, corresponding to the accumulated waste duration of about 22 hours.

Before taking ATOCIB 120mg DHG drugs treat osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

How to use

atocib is used by oral, can be used or not with food.

Dosage

Adults

arthritis or osteoarthritis (osteoarthritis): 30 mg or 60 mg once a day.

rheumatoid arthritis: 90 mg once a day.

Low vertebrae: 90 mg once a day.

Acute phosphorus arthritis (acute gout): 120 mg once a day.

Acute pain and abnormal dysmenorrhea: 120 mg once a day.

Chronic pain: 60 mg once a day.

Should only use 120 mg dose in the period with acute symptoms and maximum treatment time is 8 days.

Because cardiovascular risks can increase according to the dose and time of using COX -2 selective inhibitors, so the medication should be used in the shortest time and the lowest daily daily dosage. Should re -evaluate periodic symptoms and response to patient treatment.

Elderly

No dose adjustment.

Hepatic failure

Light liver failure (Child - Pugh from 5 - 6): Do not use more than 60 mg/day.

Creatinine clearance ≥ 30 ml/min: No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The most common side effects are suitable for the safety of Etoricoxib (for example, the effect on the digestive, the effect on the heart - kidney).

In case of an overdose, it is necessary to use common support measures, for example, removal removal is not absorbed from the gastrointestinal tract, monitoring and treating symptoms.

Etoricoxib cannot be removed by dialysis; The removal of Etoricoxib by the peritoneal cessation has not been determined.

What to do when forgetting 1 dose?

Take the next dose as instructed. Do not use additional drugs to compensate for the forgotten dose to avoid overdose.

Side Effects

When using Atocib drugs, you may experience unwanted effects (ADR).

Risk of cardiovascular thrombosis (see carefully when used).

Very common, ADR ≥ 1/10

Gastrointestinal disorders: abdominal pain.

Common, 1/100 ≤ ADR

Infections and parasites: alveolar bone.

Disorders of metabolic and nutrition: edema/keeping.

Neurological disorders: dizziness, headache.

heart disorders: arrhythmia, tachycardia.

Pleeing disorders: hypertension.

Respiratory disorders, chest area, mediastinum: bronchospasm.

Digestive disorders: constipation, flatulence, gastritis, gastroesophageal reflux, diarrhea, indigestion, discomfort, nausea, vomiting, esophagitis, mouth ulcers.

Liver disorders: Hyper enzyme AST, ALT.

Skin and subcutaneous tissue disorders: bruises.

Systemic and local disorders: weakness, influenza disease.

Uncommon, 1/1000 ≤ ADR

Infections and parasites: gastritis, upper respiratory tract infections, urinary tract.

Disorders of blood and leukemia: Anemia (often accompanied by gastrointestinal bleeding), leukopenia, thrombocytopenia.

Immune disorders: hypersensitivity.

Disorders of metabolism and nutrition: taste disorders, weight gain.

Mental disorders: Anxiety, depression, reduced sensitivity, hallucinations.

neurological disorders: taste disorders, insomnia, abnormalities, drowsiness.

eye disorders: blurred vision, conjunctivitis.

Disorders of ear and inner ears: tinnitus, dizziness.

Heart disorders: Atrial arrhythmia, tachycardia, congestion heart failure, unclear ECG changes, angina, myocardial infarction.

Vascular disorders: red face, stroke, transient ischemia, hypertension, vasculitis.

Respiratory disorders, chest area, mediastinum: cough, shortness of breath, nosebleeds.

Gastrointestinal disorders: abdominal stretch, changing intestinal motility, dry mouth, duodenal ulcer, intestinal perforation with bleeding, irritable bowel syndrome, pancreatitis.

Skin and subcutaneous tissue disorders: Facial swelling, itching, rash, erythema, urticaria.
Musculoskeletal and connective tissue disorders: cramped, musculoskeletal pain.

Renal and urinary disorders: Protein, increased serum creatinine, renal failure.

Systemic and topical disorders: chest pain.

Biochemical disorders: Hypermath of blood nitrogen, hyperninery phosphokinase, hyperkalemia, hyperuricemia.
Rare, 1/10 000 ≤ ADR
Immune disorders: vasculitis/sensitivity/anaphylaxis.

Mental disorders: Disorders, restlessness.

Hepatitis disorders: hepatitis, liver failure, jaundice.
Skin and subcutaneous tissue disorders: Stevens - Johnson syndrome, poisoning epithelial necrosis, fixed erythematosus.
Biochemical disorders: Hemati sodium.
The following serious unwanted effect is reported in combination with NSAIDs and cannot be excluded due to Etoricoxib: Kidney toxicity including interstitial nephritis and nephrotic syndrome.
Instructions on how to handle ADR
When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

ATOCIB drug contraindicated in the following cases:

allergies to any ingredients of the drug.

Stomach ulcer, progressive duodenum, stomach bleeding, intestinal inflammation.

Not for patients with allergies to aspirin and other NSAIDs.

Patients with a history of bronchospasm, bronchial asthma, acute rhinitis, nasal polyps, quincke edema, urticaria and allergic reactions after use of aspirin and other NSAIDs.

Patients with severe hepatic impairment (albumin serum

Severe renal failure (Creatinine clearance

Hemorrhage heart failure, ischemia heart disease, peripheral artery disease and/or cerebrovascular disease have been defined.

Patients with hypertension whose blood pressure is constantly raised over 140/90 mmHg and has not been fully controlled.

SECRETING HEART (NYHA II - IV).

Children and teenagers under 16 years old.

Caution when using

should be cautious when treating patients at risk of developing digestive tract complications with NSAID; Patients use separately or in combination with any other NSAIDs or acetylsalicylic acid; Patients with a history of gastrointestinal diseases such as ulcers and gastrointestinal bleeding.

Be careful to use Etoricoxib for patients with myocardial infarction, congestive heart failure, or stroke, hypertension, hyperlipidemia, diabetes, smoking.

Thinkle of kidney, cirrhosis.

Elderly

There have been reports of severe sensitivity reactions (such as anaphylactic reactions) in patients using Etoricoxib.

Heart thrombosis

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse incidents, Atocib 120 is needed at the lowest daily dose in the shortest possible time as possible.

The ability to drive and operate machinery

When using Etoricoxib is likely to be dizzy, dizziness or drowsiness, should limit driving, operate machinery, work on high and other cases.

Pregnancy

Etoricoxib is contraindicated for pregnant women.

breastfeeding period

depending on the importance of the drug for the mother that decides or stops breastfeeding or stops using the drug.

Drug interaction

Etoricoxib increases about 13% of international standardization ratio on prothrombin when used with warfarin.

Rifampicin reduces Etoricoxib level in plasma.

Plasma concentrations of methotrexate, lithium, ethinyl estradiol contraceptives, conjugated estrogen will increase when used with Etoricoxib.

Etoricoxib reduces the effectiveness of hypertension of diuretics, angiotensin transfer enzymes and angiotensin II antagonists.

Etoricoxib increases the effect of gastrointestinal ulcers when used with aspirin.

Etoricoxib has no important effect on the pharmacokinetics of Prednison, Prednisolon, Digoxin, antacids, ketoconazol.

Storage

In a dry place, the temperature does not exceed 300C, avoiding light.

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