Atorhasan 10mg Hasan medicine for hyperlipidemia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Atorvastatin
Ingredient High blood fat, high blood cholesterol

Ingredient

Composition information	Content
Atorvastatin	10mg

Uses

indications

Atorhasan 10 mg 10x10 is indicated in the following cases:

Hyper cholesterol.

Hypermathed with combined blood lipids (mixed) (hyperlotein lipoprotein LLA and ILB).

Hypermathy blood (group IV).

Betalipoprotein disorders (group III).

Preventive cardiovascular complications in patients with many risk factors. Atorvastatin also increases the number and activity of LDL receptors on the surface of liver cells. Therefore, Atorvastatin is effective in reducing LDL in patients with hyperlipidemia with homozygous genetic properties, a population that does not respond normally with other lipid medications.

Pharmacokinetics

absorption

Atorvastatin is quickly absorbed through the gastrointestinal tract, the drug has absolute low bioavailability, about 12% due to the purification in the gastrointestinal mucosa and/or the first metabolism in the liver.

Distribution

Atorvastatin binds 98% to plasma proteins.

Metabolism

Atorvastatin is metabolized through Cytochrom P450 ISOENZYM CYP3A4 into some active metabolites. Metabolic products are equivalent to Atorvastatin and participate in about 70% of HMG-CAA reducing enzymes in the body.

Elimination

Average disposal time of Atorvastatin is about 14 hours, although the time for HMG - CoA Reductase inhibits is half -by 20 - 30 hours. This is due to the contribution of active metabolites, Atorvastatin is eliminated mainly in the form of metabolites, less than 2% found in urine.

Before taking Atorhasan 10mg Hasan medicine for hyperlipidemia (10 blisters x 10 tablets)

How to use

Take oral use. Take the only dose at any time of the day, at a meal or hungry.

Dosage

Start treatment with the lowest dose that the drug has the effect, then if necessary, can adjust the dose according to the needs and response of each person by increasing the dose of each time apart for less than 4 weeks and must monitor the harmful reactions of the drug, especially the harmful reactions to the muscle system.

Patients need to follow a low cholesterol diet, before and during the use of Atorvastatin.

No dose adjustments in patients with renal failure.

Adults

Starting dose: 1 - 2 capsules/time/day. Patients who need to reduce LDL - cholesterol (over 45%) may start at a dose of 4 capsules/day.

Maintenance dose: 1 - 8 capsules/time/day. The dose can be adjusted in a period of 4 weeks to a maximum dose of 8 tablets/day.

Children (from 10 - 17 years old) increased blood cholesterol, hypercholesterolemia Hematopathy, heterozygous, hyperlipidemia (mixed)

Starting dose: 1 tablet/time/day.

adjust the dose if necessary, the dose adjustment distance is at least 4 weeks with a maximum dose of 2 tablets/time/day.

When used in combination with other drugs

When used in combination atorvastatin with amiodaron, do not use more than 20 mg atorvastatin/day.

When used in combination atorvastatin with protease inhibitors to treat HIV and hepatitis C (HCV): See interactive sections with other drugs and other types of interactions. Atorvastatin/day.

When used in combination with nelfinavir, do not use more than 40 mg atorvastatin/day.

When used in combination with Lopinavir + Ritonavir, use Atorvastatin carefully and if necessary should take the lowest dose. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In case of overdose, patients need to be treated with symptoms and necessary supportive measures. Because most of the drug is associated with plasma proteins, the hemorrhage is almost not increasing the elimination of Atorvastatin from the body.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Atorhasan 10 mg 10x10, you may experience unwanted effects (ADR).

Most of the mild and transient side effects:

Common

diarrhea, constipation, flatulence, abdominal pain and nausea in about 5% of patients; Headache (4 - 9%), dizziness (3 - 5%), blurred vision (1 - 2%), insomnia, weakness, muscle pain, joint pain; The results of the liver function test increased more than 3 times the upper limit of the normal level, in 2% of patients, but most of them were asymptomatic and recovery when stopping the drug.

muscle disease (combining muscle weakness and increasing the content of plasma creatin phosphokinase); Da Da; Rhinitis, sinusitis, sore throat, cough.

Rare

muscle inflammation, muscle pattern, leading to secondary acute renal failure due to Myoglobinuria.

Cognitive decline (such as dementia, confusion ...).

Hyperglycemia.

HBA1C.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Atorhasan 10 mg 10x10 contraindicated in the following cases:

Hypersensitivity to Atorvastatin or any ingredient of the drug.

Progressive liver disease or prolonged increased serum transaminase.

Pregnant or pregnant women, nursing women (see the use of drugs for pregnant and lactating women).

Combining Atorvastatin with Tipranavir + Ritonavir, Telaprevir (see interaction with other drugs and other types of interactions).

Be cautious when using

Consider monitoring Creatin Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to the use of statin or fibrat before, a history of liver disease and/or drinking lots of alcohol, elderly patients (> 70 years old) with risk factors for muscle pattern, special possibility of drug interactions and some special patients. In these cases, risk benefits should be considered and clinically monitoring when treated with Atorvastatin. If CK test results> 5 times the upper limit of normal levels, should not start treatment with Atorvastatin.

During Atorvastatin treatment, patients need to notify when there are muscle manifestations such as muscle pain, stiffness, muscle weakness. When there are these manifestations, patients need to test CK to take appropriate interventions.

Exzy liver enzyme test before starting atorvastatin treatment and in case of clinical indications for testing later.

Atorvastatin treatment experience in hyperlipidemia has a limited number of homozygous communications in children.

The ability to drive and operate machinery

Normally, the drug does not affect the ability to drive and operate machinery, however, the drug can cause dizziness, dizziness for a few people. Do not drive, operate machinery or do anything dangerous if there is a feeling of dizziness, dizziness.

Pregnancy

Do not use Atorvastatin for pregnant women. Using Atorvastatin only for women of reproductive age when they have effective contraception, it is difficult for patients to conceive or have been notified of the possibility of harmful to the fetus and only in the case of increased blood cholesterol without responding to other drugs. If pregnant women are taking the drug, they should stop taking the drug and the patient should be notified of the possibility of harming the fetus.

Nursing period

It is unclear whether Atorvastatin is excreted through breast milk or not. Because Atorvastatin's ability can cause serious side effects to breastfeed, do not use Atorvastatin for breastfeeding women.

Drug interaction

simultaneously used with CYP3A4 enzyme inhibitors may increase the concentration of Atorvastatin in plasma, leading to an increased risk of muscle and muscle disease.

Increased risk of muscle lesions when using Atorvastatin simultaneously with the following drugs: Gemfibrozil, other fibrat blood cholesterol medications, high doses of niacin (> 1 g/day), Colchicin, Cyclosporin, erythromycin, antifungal drugs belong to imidazol groups.

Atorvastatin increases stable digoxin levels in serum to nearly 20%. Need to monitor closely if the patient is using the two medications simultaneously.

Used in combination with amiodaron with a dose of more than 20 mg atorvastatin/day increases the risk of muscle pattern. For patients who have to take the dose of more than 20 mg atorvastatin/day to be effective for treatment, the doctor may choose another statin (like pravastatin).

Simultaneously used with oral contraceptives containing norethindron and ethinyl estradiol increases the bioavailability of these substances to 30% and 20% respectively.

Patients who are taking warfarin, anticoagulant drugs, when taking Atorvastatin need a close monitoring of a doctor.

When used simultaneously with stomach acid reducing drugs (acid-containing magnesi and aluminum) will reduce the level of Atorvastatin in plasma but do not reduce the effect of lowering the LDL-cholesterol.

The simultaneous use of statin lipid medications with protease inhibitors to treat HIV and hepatitis C (HCV) (tipranavir + ritonavir, telaprevir, lopinavir + ritonavir, darunavir + ritonavir, fosamprenavir, fosamprenavir + ritonavir, saquaVir + Ritonavir, Nelfinavir) can increase the risk of muscle damage, the most serious is muscle pattern, kidney damage leads to kidney failure and can be fatal.

Storage

Store in a dry place, less than 30 ° C.

Expiry date: 36 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.