Atorhasan 10mg Hasan medicine for hyperlipidemia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Atorvastatin
Ingredient High blood cholesterol

Ingredient

Composition information	Content
Atorvastatin	10mg

Uses

indications

Atorhasan 10 drugs are indicated in the following cases:

Hypergaric hyperemia treatment includes:

Hyper cholesterol increases.

Incaves of combined blood lipids (mixed) (hyperlotein hyperplote group IIA and IIB).

Hypermathy blood (group IV).

Betalipoprotein disorders (group III).

Increase cholesterol is heterozygous.

Supporting treatment to reduce total cholesterol and LDL - cholesterol in patients with hyperlestolic hypertension with homozygous family.

Preventing cardiovascular complications in patients has many risk factors.

Pharmacokology

Atorvastatin is a synthetic blood lipid drug, which inhibits HMG-CoA Reductase to reduce total cholesterol levels, LDL-Cholesterol, VLDL-CHOLesterol and increase HDL-CHOLesterol levels.

Atorvastatin also increases the number and activity of LDL receptors on the surface of liver cells. Therefore, Atorvastatin is effective in reducing LDL in patients with hyperlipidemia with homozygous genetic properties, a population that does not respond normally with other lipid drugs.

Dynamic pharmacokinetics

absorption

Atorvastatin quickly absorbed through the gastrointestinal tract. The drug is absolutely low bioavailability, about 12% due to the purification of the gastrointestinal mucosa and/ or the first metabolism in the liver.

distribution

Atorvastatin binds 98% to plasma protein.

transformation

Atorvastatin is metabolized through Cytochrom P450 Isoenzyme CYP3A4 into a number of active metabolites. Metabolic products are equivalent to Atorvastatin and participate in about 70% of HMG-CAA reducing enzymes in the body.

Elimination

Atorvastatin's average disposal time is about 14 hours, although the time for HMG-CoA Reductase inhibits is about half an hour due to the contribution of active metabolites.

Atorvastatin is excreted mainly in the form of a metabolic, less than 2% found in urine.

Before taking Atorhasan 10mg Hasan medicine for hyperlipidemia (3 blisters x 10 tablets)

How to use

Start treatment with the lowest dose that the drug has the effect, then if necessary, the dose can be adjusted according to the needs and response of each person by increasing the dose of each spell for no less than 4 weeks and monitoring the harmful reactions of the drug, especially the harmful reactions of the muscle system.

Patients need to follow a low cholesterol diet, before and during the use of Atorvastatin.

Take the only dose at any time of the day, at meals or hungry.

Dosage

adults

Starting dose: 1-2 capsules/ time/ day. Patients who need to reduce LDL - cholesterol (over 45 %) may start at a dose of 4 capsules/ day.

Maintenance dose: 1-8 capsules/ time/ day. The dose can be adjusted in a period of 4 weeks to the dose of 8 capsules/ day.

Children (from 10-17 years old) Hyper cholesterol, hypercholesterolemia hypothetical blood heterozygous, hypertension in combination blood lipid:

Starting dose: 1 tablet/ time/ day.

Dosage adjustment if necessary, the dose adjustment distance for at least 4 weeks with a maximum dose is 2 tablets/ time/ day.

No dose adjustment in kidney failure.

When used in combination with other drugs

When using atorvastatin combination with amiodaron, do not use more than 20 mg atorvastatin/ day.

When using atorvastatin combination with protease inhibitors to treat HIV and hepatitis C (HCV):

When used in combination with Darunavir + Ritonavir, Fosamprenavir, Fosamprenavir + Ritonavir, Saquinavir + Ritonavir, do not use more than 20 mg atorvastatin/ day.

When used in combination with nelfinavir, do not use more than 40 mg atorvastatin/day.

When used in combination with Lopinavir + Ritonavir, and Atorvastatin carefully and if necessary, the lowest dose should be used.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

In case of overdose, patients need to be treated with symptoms and necessary measures. Because most of the drug is connected to plasma proteins, the hemorrhage almost does not increase the elimination of Atorvastatin from the body.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Atorhasan 10, you may experience unwanted effects (ADR) usually light and transient:

Common, ADR> 1/100

Digestive system: diarrhea, constipation, bloating and nausea.

Nervous system: headache, dizziness, blurred vision, insomnia.

Systemic: weakness.

muscle - joint system: muscle pain, joint pain.

liver: affect liver function.

Uncommon, 1/1000

muscle disease (combining muscle weakness and increased content of plasma creatin phosphokinase); Da Da; Rhinitis, sinusitis, sore throat, cough.

rare

Myiagitis, muscle pilot, leading to secondary acute renal failure due to myoglobin urine, cognitive impairment (such as dementia, confusion ...), hyperglycemia, HBA1C.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Atorhasan 10 drug is contraindicated in the following cases:

Hypersensitivity to Atorvastatin or any ingredient of the drug.

Progressive liver disease or prolonged serum transaminase hypergension for unknown reasons.

Pregnant women or intended to get pregnant, nursing women.

Combal atorvastatin with tipranavir + ritonavir, telaprevir.

Be cautious when using

Consider monitoring Creatin Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic diseases, a history of muscle disease due to the use of statin or fibrat before, a history of liver disease and/ or drinking lots of alcohol, elderly patients (> 70 years old) have muscle risk factors, possibly abundant drugs and some compliance with drug interactive human beings and some abundance of drugs and some cases of drug interaction and some complaints and drugs. special.

In these cases should consider benefits/ risks and monitor patients clinically when treated with Atorvastatin. If CK test results> 5 times the upper limit of normal levels, do not start treatment with atorvastatin.

During Atorvastatin treatment, patients need to notify when there are muscle manifestations such as muscle pain, muscle stiffness, muscle weakness ... When there are these manifestations, patients need to test CK to take appropriate interventions.

Exzy liver test before starting atorvastatin treatment and in case of clinical indications for testing later.

Atorvastatin treatment experience in hyperlipidemia has a limited number of homozygous communications in children.

The ability to drive and operate machinery

Normally, the drug does not affect the ability to drive and operate machinery. However, the drug can be dizzy and dizzy for a few people. Do not drive, operate machinery or do anything dangerous if there is a feeling of dizziness, dizziness.

Pregnancy

Do not use Atorvastatin for pregnant women.

Only use Atorvastatin for women of the age of birth so that when they have effective contraception, it is difficult for patients to conceive or have been notified of the possibility of harm to the fetus and only in the case of increased blood cholesterol without responding to other drugs.

If pregnant women are taking the drug, they should stop taking the drug and the patient should be notified of the possibility of harm to the fetus.

The period of breastfeeding

It is unclear whether Atorvastatin is excreted through breast milk or not.

Because Atorvastatin's ability can cause serious side effects to breastfeed, do not use Atorvastatin for breastfeeding women.

Drug interaction

simultaneously used with CYP3A4 enzyme inhibitors may increase the concentration of Atorvastatin in plasma, leading to an increased risk of muscle and muscle disease.

Increased risk of muscle lesions when using Atorvastatin simultaneously with the following drugs: Gemfibrozil, other fibrat blood cholesterol medications, high doses of niacin (> 1 g/day), Colchicin, Cyclosporin, erythromycin, antifungal belonging to IMidazol group.

Atorvastatin increases stable digoxin levels in serum to nearly 20%. Need to monitor closely if the patient is using the two drugs simultaneously.

Used in combination with amiodaron with a dose of more than 20 mg atorvastatin/day increases the risk of muscle pattern. For patients who have to take the dose of more than 20 mg atorvastatin/ day to be effective for treatment, the doctor may choose another statin (such as pravastatin).

Concentrated with oral contraceptives containing norethindron and ethinyl estradiol increases the bioavailability of these substances to 30% and 20% respectively.

Patients who are taking warfarin, anticoagulant drug, when taking Atorvastatin need a close monitoring of a doctor.

When concurrent use with stomach acid reducing drugs (acid -containing magnesi and aluminum) will reduce the level of Atorvastatin in plasma but do not reduce the effect of lowering LDL - cholesterol.

The simultaneous use of statin lipid medications with protease inhibitors to treat HIV and hepatitis C (HCV) (tipranavir + ritonavir, telaprevir, lopinavir + ritonavir, darunavir + ritonavir, fosamprenavir, fosamprenavir + ritonavir, saquaVir + Ritonavir, Nelfinavir) can increase the risk of muscle damage, the most serious is muscle pattern, kidney damage leads to kidney failure and can be fatal.

Storage

in a dry place, less than 30ºC.

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