Atorlip 20mg DHG medicine for total cholesterol treatment and LDL-Cholesterol (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Atorvastatin
Ingredient Atherosclerosis, blood fat, high blood cholesterol

Ingredient

Composition information	Content
Atorvastatin	20mg

Uses

indications

Atorlip 20 drugs are indicated in the following cases:

Increase total cholesterol, increase ldl-cholesterol, increase triglycerides. circuit. Mevalonate, precursor of cholesterol. Atorvastatin reduces lipoprotein and plasma cholesterol by inhibiting the synthesis of cholesterol in the liver and by increasing the number of LDL receptors (low density lipoprotein) in the liver on the cell surface, thereby increasing the removal and degradation of LDL.

Atorvastatin reduces the strongest LDL cholesterol (25 - 61%) compared to any drug used alone, and proved prospects for patients who need to reduce cholesterol, which is now only achieved when combined with drugs. Atorvastatin increases the concentration of HDL cholesterol (high density lipoprotein) from 5 - 15% and thus lowering LDL/HDL ratios and total/HDL cholesterol. Atorvastatin also reduces plasma triglycerides at level 10 - 30% by increasing the clearance of VLDL (Lipoprotein very low density) residues thanks to the LDL receptor.

In clinical studies, evidence suggests that statins significantly reduce coronary artery events, all cardiovascular events have existed and reduce the total number of deaths in people with coronary artery disease.

pharmacokinetic

absorption

Atorvastatin is quickly absorbed after drinking, the peak of plasma is reached within 1 to 2 hours. The level of absorption and concentration of Atorvastatin in plasma increases proportional to the dose of Atorvastatin. Atorvastatin tablets for bioavailability equal to 95% to 99% of the solution form. The absolute bioavailability of Atorvastatin is approximately 14% and the whole body for HMG - COA inhibitors is approximately 30%. Low body bioavailability is due to the clearance of the gastrointestinal mucosa or the first metabolism through the liver before the common circulation.

Although the food reduces the rate and absorption of the drug, approximately 25% and 9%, when assessed according to the high plasma peak concentration and the area under the curve (AUC), the effectiveness of the LDL - C effect is similar to the same as the Atorvastatin is used or not used with the same food. Atorvastatin concentration in blood is approximately 30% for CMAX and AUC) when taking the drug in the evening compared to when used in the morning. However, the effectiveness of LDL reduces regardless of the medication during the day (see also the dose and how to use).

Distribution

The average distribution of Atorvastatin is approximately 381L. At the cohesion of the year of birth 205 - 12 - The concentration of drugs in red blood cells, the concentration of drugs in plasma is approximately 0.25; This shows that the poor penetration of the drug into Aldieselec metabolizes mainly into hydroxylation derivatives at Ortho and Para positions and the products of oxidation in the position on the in vitro, the HMG - COA inhibiting effect of hydroxylation metabolites in Ortho and Para positions are similar and this effect of Atorvastatin. Approximately 70% of the inhibition activity in the circulation for HMG - COA enzymes is due to active metabolites. In Vitro studies suggest the importance of Atorvastatin metabolism by CYP3A4 suitable for high blood atorvastatin levels in humans after using simultaneously with erythromycin, a known inhibitor for this iszym. In vitro studies also show that Atorvastatin is a weak inhibitor for CYP3A4.

Simultaneous use of Atorvastatin with terfenadin does not affect clinically the plasma concentration of Terfenadin, a compound metabolized mainly by CYP3A4, so Atorvastatin will not change significantly on the substrates of CYP3A4 (see more interactive parts, cavalry of the drug). In animals, hydroxy metabolites in the ortho position also undergo glucuronide.

Elimination

Atorvastatin and its metabolites are excreted mainly after bile after being metabolized in the liver or outside the liver, but the drug does not seem to have a cycle of re -circulating the liver. The average selling time in the plasma of Atorvastatin in humans is approximately 14 hours, but the sale time of the inhibitory activity for HMG - COA reducing enzymes is 20-30 hours due to the contribution of active metabolites. Under 2% of Atorvastatin dose is found in urine after drinking.

Special target groups

Elderly

Atorvastatin concentration in plasma in elderly (2 65 years old) is higher (approximately 40% for CMA and 30% for AUC) compared to young people. Researching Access aims to especially evaluate elderly patients about achieving the goals of treatment under the National Education Program on Cholesterol (NCEP). This study includes 1,087 patients

Before taking Atorlip 20mg DHG medicine for total cholesterol treatment and LDL-Cholesterol (3 blisters x 10 tablets)

How to use

oral drugs. The drug can be taken at any time of the day and does not depend on the meal.

Dosage

Before conducting treatment with Atorvastatin, it is necessary to control blood cholesterol hyperpactive condition by a reasonable diet, exercise and weight loss in obese patients and basic treatment. Patients should maintain a standard diet to reduce cholesterol during Atorvastatin treatment.

The dose is in the range of 10mg to 80mg once a day. Atorvastatin doses can be used at any time of the day, whether or not food is accompanied by food. The starting and maintenance dose should be used to concretize each patient depending on the initial LDL-C level, the patient's treatment and response goals. After the beginning of treatment during the standard dose process of Atorvastatin, the lipid concentration is needed for 2 to 4 weeks and follow the dose adjustment accordingly.

Adults

Increasing primary blood cholesterol and coordinated blood lipid (mixed)

Most patients are controlled at a dose of 10mg atorvastatin once a day. Response treatment appears clearly within 2 weeks and maximum response is usually achieved within 4 weeks. This response is maintained during long -term use.

Hyper cholesterol is homozygous

Atorvastatin's dose in patients with hypercholesteroline hypertension with homozygous family is 10mg to 80mg/day. In these patients, Atorvastatin should be used in combination with other blood lipid therapies (such as LDL transmission) or used when there are no other therapies.

Cardiovascular Prevention

In the main test of cardiovascular disease prevention, the dose is 10mg day. The dose can be increased to reach cholesterol levels (LDL - C) according to the current instructions.

Children

Pediatric patients with hypercholesterol

The use of collection in children should only be performed by doctors who have experience in treating hyperlipidemia in children and should regularly evaluate the treatment process.

For patients with hypercast hyperchemical hyperlly heterozygous family 10 years of age and older, Atorvastatin's recommended starting dose is 10mg daily. There is a way to increase the daily dose of up to 80mg according to the response and the ability to tolerate drugs ..

Need to adjust the dose on each patient object according to the recommended treatment goals. The adjustments must be made over 4 weeks or more. The adjustment of the dose up to 80mg daily is based on the research data in adults and the clinical data is limited from studies on children with hyperplastic hyperplastic hyperplation.

What to do when overdose?

What to do when forgetting 1 dose? However, if the time is relaxed with the next dose

Side Effects

When using Atorlip 20, you may experience unwanted effects (ADR):

diarrhea, constipation, flatulence, headache, joint pain, forgetting or losing memory, confusion, pain or weakness, lack of energy, fever, chest tightness, nausea, excessive fatigue, weakness, abnormal bleeding or bruising, appetite, pain in the upper right of the stomach, symptoms like flu, urine with dark color, jaundice or eyes, rash, rash, hard -to -rash, itchy, difficulty, rash, rash, rash, itchy, hardening Eyes, arms, feet, ankles or lower legs, hoarseness. Atorvastatin can cause other side effects.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications

Patients with hypersensitivity to any ingredients of the drug.

Patients with progressive liver disease.

Patients with persistent serum transaminase and exceed 3 times the upper limit of normal level.

Pregnant or suspected pregnant women and nursing women do not take drugs.

Precautions when using

Before starting treatment, it is necessary to determine the cause of blood cholesterol hyperplasia and quantify lipid indicators to determine treatment dose. Be cautious with patients drinking a lot of alcohol.

Be cautious when used for patients with a history of liver disease.

Dose or stop treatment and report to the doctor immediately if there is a strange manifestation.

The ability to drive and operate machinery

The drug has almost no effect on driving and operating machinery. However, there are also a few reports on the risk of dizziness, so the doctor may depend on the specific case that is recommended or not recommended for patients to use drugs when driving and operating machinery.

Pregnancy

Atorvastatin is contraindicated during pregnancy. Safety in pregnant women has not been determined, there is no clinical research with control of Atorvastatin in pregnant women. Rarely there are reports on birth defects encountered after exposure to HMG-CoA Reductase inhibitors. Animal studies have shown the toxicity of the drug for the reproductive system. The mother treated with Atorvastatin will reduce the level of meevalonate (precursors of the fetal cholesterol synthesis).

Atherosclerosis is a chronic process and the discontinuation of lipid lowering during pregnancy has a very small impact on the long -term risk of blood cholesterol hypercactive.

Therefore, Atorvastatin should therefore be used in pregnant women, preparing to get pregnant or suspected of being pregnant. Atorvastatin treatment should be suspended during pregnancy until sure that the patient is not pregnant.

Breastfeeding period

Not yet determined whether Atorvastatin and metabolites are excreted through breast milk. In mice, the plasma concentration of Atorvastatin and metabolites are equivalent in milk. Due to the risk of serious side effects, women use Atorvastatin should not be breastfeeding. Atorvastatin is contraindicated in this object.

Medicinal interaction

cyclosporin, Fibric acid derivatives, erythromycin, niacin, antifungal group Azole. Antacids, colestipol, digoxin.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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