Atorlog 20mg Bidiphar medicine for total cholesterol treatment and LDL-cholesterol (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Atorvastatin
Ingredient High blood fat, high blood cholesterol

Ingredient

Composition information	Content
Atorvastatin	20mg

Uses

Indications

Atorvastatin is indicated in the case of total cholesterol hypertrophy and LDL cholesterol in patients with hypercholesterol blood cholesterol with homosexual family factors, complementary to other lipid treatments.

Pharmacokology

Atorvastatin is a blood lipid hyperplation of HMG inhibitor group - CoA Reductase, Statin group. Statin is competitive inhibitors with hydroxy - methylglutaryl Coenzyme (HMG - CoA) Reductase, preventing HMG - Mmalonate coa, precursor of cholesterol. States inhibit cholesterol biosynthesis, reduce cholesterol in liver cells, stimulate the synthesis of LDL receptors (low density lipoprotein), and thereby increase LDL transport from blood.

These biochemical processes reduce cholesterol levels in plasma. At normal doses, HMG - CoA Reductase is not completely inhibited, so there is still enough meevalonic acid for many metabolic processes.

States increase HDL cholesterol levels (higher lipoprotein) from 5-15% and thus lower LDL ratios (Lipoprotein ratio)/HDL and global/HDL cholesterol. Statin also reduces plasma triglycerides at a lower level (10-30%) by increasing VLDL clearance (Lipoprotein in very low) residual residues thanks to LDL receptors.

Response treatment with statins can be seen within 1-2 weeks after starting the drug and usually reaches up to 4-6 weeks. Maintenance response during long -term treatment.

pharmacokinetic

Atorvastatin is quickly absorbed after drinking and is not affected by food. The bioavailability of atorvastatin is low because it is strongly metabolized through the liver and reaches the peak concentration in serum 1 - 2: Atorvastatin's protein bonds> 98%. Atorvastatin body oil should pass through the bloody barrier.

All metabolic statins are mainly in the liver, into specialized substances with or non -active, then excreted mainly through feces. Elimination through the kidneys of Atorvastatin

Before taking Atorlog 20mg Bidiphar medicine for total cholesterol treatment and LDL-cholesterol (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

start dose 10 mg once a day.

Adjust the dose every 4 weeks, if necessary and if tolerated.

Maintain dose 10-40 mg/day.

If necessary, the dose can be increased, but not more than 80 mg/day.

When used in combination with amiodarone, do not use more than 20 mg/day.

When used in combination with Darunavir + Ritonavir, Fosamprenavir, Fosamprenavir + Ritonavir, Saquinavir + Ritonavir, do not use more than 20 mg/day.

When used in combination with nelfinavir, do not use more than 40 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Due to the drug associated with plasma proteins, hemorrhage does not significantly increase the clearing of statins ..

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Atorlog 20 Bidiphar, you may experience unwanted effects (ADR).

Common

diarrhea, constipation, flatulence, abdominal pain, and nausea.

Headache, dizziness, blurred vision, sleeping eyes, weakness.

muscle pain, joint pain.

liver: The test results of liver function increases more than 3 times the upper limit of normal.

Uncommon:

muscle disease (combining muscle weakness and increasing the content of creatine phosphokinase plasma (CPK).

skin.

Rhinitis, sinusitis, sore throat, cough.

Rare: muscle inflammation, muscular pattern, leading to secondary acute renal failure caused by myoglobin.

In addition, some other unwanted effects may occur such as: Cognitive decline (memory loss, confusion ....) Hyperglycemia, Hbaic.

Notify the doctor with unwanted effects when using the drug.

Warnings

Contraindicated

Atorlog 20 Bidiphar is contraindicated in the following cases:

Hypersensitivity to HMG inhibitors - CoA Reductase or any ingredients of the preparation.

Precautions when using

need to conduct liver enzyme tests before starting statin treatment and when clinical indicators require previous tests.

Need to use caution in patients with alcohol and/or a history of liver disease. Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to the use of statin or fibrat before, the history of liver disease and/or drinking lots of alcohol, elderly patients (70 years old) have risks in risk of muscle pilot, the possibility of drug interactions and some special patients. In these cases, the benefits/risks should be considered and monitor patients clinically when treated with statin. If the results of CK test> 5 times the upper limit of normal levels, do not start treatment with statin.

During statin treatment, patients need to notify when there are muscle manifestations such as muscle pain, stiffness, muscle weakness ... When these manifestations, patients need to do CK test to take appropriate interventions.

Statin therapy must be suspended or only in the patient who shows signs of acute and severe muscle disease or has a risk of risk of acute renal failure due to muscle pattern, such as severe acute bacterial infections, hypotension, surgery and large injury, abnormalities in specialized, hormonal, electrolytes or uncontrolled convulsions.

Use cautiously atorvastatin with Lopinavir + Ritonavir and if necessary, use the most staple atorvastatin.

Only use statin for women of reproductive age when they are certainly not pregnant and only in the case of hyperlestoly blood cholesterol is very high without responding to other drugs.

The ability to drive and operate machinery

drugs have side effects that cause headaches, dizziness, insomnia so be cautious when driving and operating the machine.

Pregnancy

Not used.

Breastfeeding period

Not used.

Drug interaction

often experience more muscle and muscle pepper in patients with statin coordination treatment with cyclosporin, erythromycin, otraconazole, ketoconazole (due to Cytochrome CYP3A4).

Statin can increase the effects of warfarin, so prothrombin should be determined before starting to use statin and regular monitoring in the first stage of using statin.

Bile acid -mounted resins can significantly reduce the bioavailability of the statin when taken with them, so they should use these two drugs apart.

Increased risk of muscle lesions when using statin simultaneously with the following drugs: Gemfibrozil, fibrat blood cholesterol subordinates, high -dose niacin (> 1 g/ day), Colchicine.

Concomitance the use of statins with protease inhibitors of HIV and HCV may increase the risk of causing muscle damage, the most serious is muscle pattern, kidney damage leading to kidney failure and can be fatal.

Storage

In a dry place, avoid moisture, avoid light, temperature

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