Atorvastatin 10mg TV.PHARM Treatment for total cholesterol, LDL-Cholesterol (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Atorvastatin
Ingredient Atherosclerosis, blood fat, high blood cholesterol

Ingredient

Composition information	Content
Atorvastatin	10mg

Uses

indications

Atorvastatin 10mg drug is indicated in the following cases:

Single cholesterol, LDL - Cholesterol and Apolipoprotein B in patients with primary cholesterol and mixed lipid metabolic disorders. It is necessary to follow a diet to achieve high therapeutic effect. 3-Hydroxy-3-methyl-glutaryl-coenzyme A into Mevalonate, a precursor of sterols, including cholesterol. Cholesterol and triglycerides circulate in blood in the form of lipoprotein molecules.

These molecules are divided into high molecular weight lipoprotein (HDL), medium molecular weight lipoprotein (IDL), low molecular weight lipoprotein (LDL) and lipoprotein very low molecular weight (VLDL). Triglycerides and cholesterol combined into VLDL in the liver. From the liver they are released into plasma to go to peripheral tissues.

LDL is formed from VLDL and degenerated mainly through the LDL receptors. Clinical and pathological studies have shown that the increase in total cholesterol levels, LDL cholesterol and Apolipoprotein B (APO B) in the blood increases atherosclerosis in humans and increases the risk factors for cardiovascular disease, while increasing HDL cholesterol reduces the risk of cardiovascular disease.

Atorvastatin reduces total cholesterol, LDL cholesterol and apoprotein B in diseases of hyperchemical hypercholesterol family and heterozygous, hyperplasia and mixed blood lipids. It also reduces VLDL cholesterol and triglycerides and increases HDL cholesterol and Apolipoprotein A-1. Atorvastatin reduces total cholesterol, LDL cholesterol, VLDL cholesterol, APO B, Triglycerides, and non -HDL cholesterol and HDL cholesterol hyperplasia in hyperlage patients with triglycerides are simple. It reduces the average density cholesterol (IDL cholesterol) in patients with blood lipoprotein metabolism disorders.

Efficiency of Atorvastatin on the death rate and cardiovascular events have not been set up.

pharmacokinetics

absorption:

Atorvastatin absorbs rapidly after drinking, the maximum concentration in plasma is achieved after 1 to 2 hours. Atorvastatin absorption level increases corresponding to the dose. Atorvastatin's bioavailability is about 14% and the whole body of the body inhibits HMG-CAA reducing enzymes is about 30%.

Distribution:

The distribution of Atorvastatin is about 381 liters. More than 98% Atorvastatin is attached to plasma. The ratio in the blood/plasma is about 0.25 shows that the drug is soaked into red blood cells. Based on mice research, Atorvastatin may eliminate milk.

Metabolism:

Atorvastatin metabolizes mainly into hydroxylation derivatives at Ortho and Para positions and oxidized products at beta.

Era:

Atorvastatin and its metabolites are excreted mainly into bile after the metabolism through the liver and/or outside the liver. However, the drug does not go through the gut liver cycle.

Atorvastatin's waste time is about 14 hours, but the sale time of the elimination of COA reducing enzymes is about 20 to 30 hours due to the main metabolites of Atorvastatin. Under 2% is found in urine.

Before taking Atorvastatin 10mg TV.PHARM Treatment for total cholesterol, LDL-Cholesterol (3 blisters x 10 tablets)

How to use

Take oral use. Recommendation to start treatment with the lowest dose that the drug works, then if necessary, the dose can be adjusted according to the needs and response of each person by increasing the dose of each time apart from less than 04 weeks and must monitor the harmful reactions of the drug, especially the harmful reactions to the muscle system.

Dosage

Atorvastatin when used in combination with amiodaron: Do not use more than 20mg/day.

Need to follow a diet to reduce cholesterol.

Start: 10mg/day. The dose can be adjusted (if necessary) after 4 weeks of treatment.

Maintenance dose: 10 - 40mg/day. Can increase the dose but not more than 80mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of overdose, patients need to be treated with symptoms, and use other necessary supportive measures to maintain living functions. Because most of the drug is associated with plasma proteins, the hemorrhage is almost not increasing the elimination of Atorvastatin from the body.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Atorvastatin 10mg medicine, you may experience unwanted effects (ADR) fleeting:

Common, ADR> 1/100

Digestive system: constipation, flatulence, indigestion, abdominal pain, vomiting, diarrhea.

Nervous system: weakness, headache, insomnia, cognitive impairment.

musculoskeletal system: muscle pain, myasthenia, weakness.

liver: increased liver enzymes, increased content of plasma creatinine phosphokinase.

Metabolic disorders: hyperglycemia, HBA1C.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Atorvastatin 10mg drug is contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Progressive liver disease, liver disease has an increase in prolonged serum transaminase.

Pregnant women, nursing women.

Itraconazole antifungal drugs, ketoconazole, fibrat drug group.

Caution when using

It is necessary to consider when using Atorvastatin for patients with risk factors leading to muscle damage. Atorvastatin is at risk of harmful reactions to muscle systems such as muscle atrophy, muscleitis, especially for patients with risk factors such as patients over 65 years old, patients with unproven thyroid diseases, patients with kidney disease. Need to closely monitor the harmful reactions during the use of the drug.

Before treatment with Atorvastatin must eliminate the causes of blood cholesterol due to: underdogy -controlled diabetes, blood protein disorders, biliary liver disease, due to some other drugs, alcoholism.

Must conduct total cholesterol quantitative, LDL cholesterol, HDL cholesterol and triglycerides.

Must conduct periodic lipid quantification, with a distance of less than 4 weeks, and adjust the dosage according to the patient's response to the drug.

It is necessary to conduct liver enzyme tests before and while starting with atorvastatin.

Consider monitoring Creatin Kinase (CK) in the case:

Before the treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic diseases, a history of muscle disease due to the use of Atorvastatin or previous fibrat, a history of liver disease and/or drinking lots of alcohol, elderly patients (> 70 years) special. In these cases, the benefits/risks should be considered and monitor patients clinically when treated with Atorvastatin. If CK test results> 5 times the upper limit of normal levels, do not start treatment with atorvastatin.

During Atorvastatin treatment when there are muscle manifestations such as muscle pain, stiff muscle, muscle weakness, ... Patients need to do CK test to take appropriate interventions.

Patients with hyginase alat or Asat increases should be monitored until the resolving abnormalities, if the concentration increases to 3 times the limit above the normal level is required to stop treatment.

Be cautious when taking medicine for patients to drink plenty of alcohol or a history of liver disease.

Need to stop or terminate Atorvastatin treatment when the patient has severe acute symptoms of muscle disease or risk factors leading to the development of secondary renal failure into globulin ureter (severe infections, hypotension, surgery, injury, electrolyte disorders, hormonal and severe conversion, non -control epilepsy).

The ability to drive and operate machinery

can be used.

Pregnancy

contraindicated.

breastfeeding period

contraindicated.

Medicine interaction

using Atorvastatin along with enzyme inhibitors CYP3A4 can increase the concentration of Atorvastatin in plasma, leading to an increased risk of muscle and muscle disease.

Atorvastatin when used in combination with amiodaron, should not be used more than 20mg/day because of the increased risk of muscle pattern. For patients who have to take a dose of over 20mg/day to be effective for treatment, the doctor may choose another stalin (like pravastatin).

Increased risk of muscle damage when using Atorvastatin simultaneously with the following drugs: Gemfibrozil; other fibrat blood cholesterol medications; High doses (> 1 g/ day); Colchicin.

Avoid simultaneous use of Atorvastatin with oral epidemics used orally containing magnesi, aluminum hydroxyd and cholestyramine due to reducing the concentration of Atorvastatin in plasma.

Caruscastatin levels in plasma will increase when used simultaneously with digoxin, erythromycin or clarithromycin.

Be cautious when used with birth control pills will increase the effects of birth control pills.

Used with HIV treatment, HCV can cause muscle damage and kidney damage leading to kidney failure.

Storage

Store in a dry place, avoid sunlight.

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