Atorvastatin 40mg Savi treats blood lipid disorders, blood fat, high blood cholesterol (3 blisters x 10 tablets)

Atorvastatin reduces LDL levels very effectively. This group of drugs lowered LDL cholesterol from 25% to 45% depending on the dose.

Atorvastatin reduces the strongest LDL cholesterol (25 - 61%) compared to any drug used alone and has a prospect for patients who need to reduce cholesterol, which is now only achieved when combined with drugs. Atorvastatin increases the concentration of HDL cholesterol (high density lipoprotein) from 5 to 15% and thus lowering LDL/HDL ratios and cholesterol all/HDL. Atorvastatin also reduces plasma triglycerides at a lower level (10% to 30%) by increasing LDL clearance (Lipoprotein very low density) residues thanks to LDL receptors. A response to Atorvastatin can be seen within 1-2 weeks after starting the drug and usually reaches up to 4-6 weeks. Maintain maintenance during long -term treatment. In clinical studies, evidence suggests that statins significantly reduce coronary artery events, all cardiovascular events have existed and reduce the total number of deaths in people with coronary artery disease (with a history of angina or acute myocardial infarction) and people with plasma cholesterol 5.5 mmol/liter or higher.

Atorvastatin also plays a role in the primary disease prevention (acute 1) coronary artery disease in patients with hypercholesterol higher risk of coronary artery event. The high doses of Atorvastatin are strongly acting, which can reduce triglyceride levels. Atorvastatin is also used to increase HDLC, but clinical significance must be proven.

pharmacokinetics

Atorvastatin quickly absorbed. The biological transformation of Atorvastatin is an active form. Atorvastatin's absorption is not affected by food. The bioavailability of Atorvastatin is low because it is strongly metabolized in the liver (> 60%). Time to reach the peak concentration of Atorvastatin from 1-2 hours.

Atorvastatin's protein bonds> 98%, Atorvastatin likes fat, should pass through the blood -brain barrier. Atorvastatin metabolizes mainly in the liver (> 70%) into metabolites with or non -active, then eliminates a lot of stool. Elimination through the kidneys of Atorvastatin

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? No patient has special symptoms and all patients recover without sequelae.

If an overdose occurs, symptomatic treatment and support when necessary. Due to the strong drug associated with plasma proteins, the hemorrhage does not expect significantly increasing statin.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Neuros - muscles and bones: muscle inflammation, muscle pilot, leading to secondary acute renal failure due to myoglobinuria.

Side effects are recorded during the circulation of the drug:

Changes in serum liver enzyme concentration usually occur in the first months of statin treatment. Any patient with high serum aminotransferase must monitor the second liver function test to confirm the results and monitor treatment until the abnormalities return to normal. If the concentration of aminotransferase (transaminase) serum AST or ALT (GOT or GPT) persisted more than 3 times the upper limit of normal, it is necessary to stop treating with statin.

Advice patients to use statin immediately report any manifestation such as muscle pain for unknown reasons, sensitivity and muscle weakness, especially if accompanied by discomfort or fever. Statin therapy must be stopped if the CPK concentration increases significantly, 10 times higher than the upper limit of normal and if diagnosed or suspected is muscle disease.

Be cautious when using

Consider when taking drugs belonging to the statin group for patients with risk factors leading to muscle lesions. The drug in the statin group is at risk of causing harmful reactions to the muscle system such as muscle atrophy, muscle inflammation, especially for patients with risk factors such as patients over 65 years old, patients with untreated thyroid diseases, patients with kidney disease. Need to closely monitor the harmful reactions during the use of the drug.

Avoid using the following medications: Gemfibrozil; other fibrate blood cholesterol medications; High doses (> 1g/day); Colchicin ... due to increased risk of muscle damage.

Be cautious when using statin lipid medications with HIV and hepatitis C (HCV) because it can increase the risk of muscle damage, most serious is muscle pattern, kidney damage leading to kidney failure and can be fatal.

Before starting treatment with Atorvastatin, it is necessary to eliminate the causes of hypercholesterol (for example, under controlled diabetes, thyroid defect, nephrotic syndrome, blood protein disorders, biliary clogged liver disease, due to some other drugs, alcoholism) and quantification of total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride. Periodic lipid quantification must be conducted, with a distance of less than 4 weeks, and adjust the dosage according to the patient's response to the drug. The goal of treatment is to reduce LDL cholesterol so it is necessary to determine the level of LDL cholesterol to start treatment and evaluate treatment. Only when the LDL cholestrol is not tested, will the total cholesterol use to monitor treatment.

In clinical trials, a small number of adult patients drink Atorvastatin see significantly increasing serum transaminase (> 3 normal limits). When stopping the drug in these patients, Transaminase concentration often lowered to the level before treatment. Some of these patients before treatment with Atorvastatin have had abnormal liver function test results and/or drink plenty of alcohol. Caution should be used in patients with a lot of alcohol and/or a history of liver disease. Therefore, liver enzyme tests should be taken before starting statin treatment and in case of clinical indications for testing later.

Consider monitoring Creatine Kinase (CK) in the case:

Before treatment:

CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to the use of statin or fibrate before, a history of liver disease and/or drinking lots of alcohol, elderly patients (> 70 years old) have risk factors for muscle eligibility, the possibility of drug interactions and some special patients.

In these cases, the benefits/risks should be considered for clinical patients when treated with statin. If the results of CK test> 5 times the upper limit of normal levels, do not start treatment with statin.

During treatment:

Patients need to notify when there are muscle manifestations such as muscle pain, stiffness, muscle weakness ... When there are these manifestations, patients need to test CK to take appropriate interventions.

Atorvastatin therapy must be temporarily suspended or stop in any patient who shows signs of acute and severe muscle disease or has risk factors prone to acute renal failure due to muscle pattern, such as severe acute bacterial infections, hypotension, surgery and large trauma, abnormalities in metabolism, endocrine, electrolytes or uncontrolled convulsions.

Only use Atorvastatin for women of reproductive age when they are certainly not pregnant and only in the case of hyperlestoly blood cholesterol very high without responding to other drugs.

The effect of the drug on driving and operating machinery

studies to determine the influence of Atorvastatin on driving and operating machinery has not been done. When driving or operating the machine should note that dizziness may occur during treatment.

Use drugs for women during pregnancy and lactation

pregnancy:

Because statins reduce cholesterol synthesis and maybe many other substances have biological activity derived from cholesterol, the drug can be harmful to the fetus if used for pregnant women. So contraindicated use of statin during pregnancy.

breastfeeding period:

Many statins are distributed into milk. Because the potential has a serious unwanted effect for breastfeeding children, contraindicated use of statin in nursing mothers.

Drug interaction

foxes about interactions between statins and HIV -resistant protease and HCV inhibitors:

Statin may increase the effects of warfarin. Prothrombin must be determined before starting to use statin and regular monitoring in the first stage of treatment to ensure no change in prothrombin time.

When used in combination with amiodaron, do not use more than 20mg/day.

Bile acid -mounted resins can significantly reduce the bioavailability of statin when taken. So the time to use these 2 drugs must be apart.

Although there is no clinical interactive studies in clinical interactions, there is no clinical interactive manifestation of clinical significance when using statin along with angiotensin transferring enzymes, beta blockers, calcium channel blockers, diuretics and nonsteroidal anti -inflammatory drugs.