Atussin United medicine supports reducing cough symptoms (25 blisters x 4 tablets)

Dosage form Box of 25 blisters x 4 tablets
Specifications Sodium citrate, chlorpheniramine, dextromethorphan, ammonium chloride, guaifenesin
Ingredient United

Ingredient

Composition information	Content
Sodium citrate	133mg
Chlorpheniramine	1mg
Dextromethorphan	10mg
Ammonium chloride	50mg
Guiifenesin	50mg

Uses

Indications

Atussin is indicated in the following cases:

Reduces symptoms of coughs due to colds, flu, tuberculosis, bronchitis, pertussis, measles, pneumonia, pneumonia - bronchial, sore throat, laryngitis, trachea inflammation, bronchitis, irritated pleura, too much smoking, inhalation of irritants, and coughs with central origin.

Pharmacokology

Dextromethorphan HBr

Dextromethorphan HBr is a cough medicine that works on the cough center in the brain. Dextromethorphan is most effective in the treatment of chronic cough, cough without phlegm. With the treatment dose, the anti -cough effect of the drug lasts 5 - 6 hours.

chlorpheniramine maleaty

Chlorpheniramine Maleatate is an antihistamine with very little sedative effects. Like most other antihistamines, chlorpheniramine also has side effects against acetylcholin secretion, but this effect varies greatly among individuals. The antihistamine antihistamine effect of chlorpheniramine through the block of the h1 receptor of the acting cells.

Sodium citrate dragon fruits are moisturized and play a role in maintaining pH. Ammonium chloride makes long talks thanks to the effect of stimulating mucous membranes. Glyceryl Guaiacolate makes long talks by reducing the viscosity of the mucus.

Pharmacokinetics

Dextromethorphan HBr

Dextromethorphan is quickly absorbed through the gastrointestinal tract and works within 15 - 30 minutes after drinking, lasting 6 - 8 hours. The drug is metabolized in the liver and excreted through the urine in the form of constant and Demethyl metabolites, among them dextrorphan also has a slight cough reduction effect.

chlorpheniramine maleaty

Chlorpheniramine Maleate absorbs well when drinking and appears in plasma for 30 - 60 minutes. Plasma peak concentration reaches 2.5 to 6 hours after drinking. Low biological use, reaching 25-50%. About 70% of the drug during the circulation associated with the protein. The distribution volume is about 3.5l/kg (adults) and 7 - 10l/kg (children). The drug is excreted mainly in urine in the form of constant or metabolic, the excretion depends on the pH and the urine flow. Only a small amount is seen in the feces. The sale time is 12 - 15 hours.

The substances of Dam

sodium citrate is absorbed and converted into sodium bicarbonate.

Ammonium chloride absorbs well through the gastrointestinal tract. NH4+ ions converted into urea in the liver. CL- ion release into blood and extracellular fluid causes metabolic acidosis and decreased urine pH, followed by fleeting diuretic.

glyceryl Guaiacolate is absorbed through the gastrointestinal tract. It is metabolized and excreted in urine.

Before taking Atussin United medicine supports reducing cough symptoms (25 blisters x 4 tablets)

How to use

You should use the drug as directed by the doctor and check the information on the label for instructions on the exact medication. In particular, you do not use the drug in low doses, high or longer than the specified time.

You can take the medicine with or not with food. However, you can take the drug with food to reduce the stomach irritation. Besides, you need to take the tablet with a full glass of water.

Dosage

Take every 6 to 8 hours or as instructed by a physician.

adults and children over 12 years old

1 - 2 tablets/time.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Treatment: Support, use Naloxone 2mg intravenously, for a total dose of 10mg if needed.

The overdose symptom of chlorpheniramine includes drowsiness, central nervous stimulation, seizure, apnea, convulsions, anti -secretion effects Acetylcholine, hypertonic reaction and cardiovascular collapse, arrhythmia.

Symptomatic treatment and support: gastric lavage or vomiting with ipecacuanha syrup; Then use activated carbon and bleach to limit absorption. In the case of hypotension and arrhythmia, it should be actively treated. Diazepam or intravenous phenytoin may be helpful to treat convulsions. Can blood transfusion in heavy cases.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Atussin, you may experience unwanted effects (ADR) such as:

Fatigue, dizziness, headache, tachycardia, nausea, vomiting, diarrhea, redness, urticaria, sleeping chicken, sedation, dry mouth.

Please notify your doctor the unwanted effects when taking the drug.

Instructions on how to handle ADR

Can reduce the side effects of the drug by reducing the dose.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ATussin drugs contraindicated in the following cases:

Patients who are sensitive to the ingredients of the drug or are using monoamine oxidase inhibitors.

Patients are suffering from acute asthma attacks, narrow -angle glaucoms, stomach ulcers, pyloric switches, and urine stasis due to urethral - prostate disorders.

Precautions when using

Caution when taking Atussin for patients with coughs with too much phlegm, chronic cough in smokers, asthma, pulmonary overflow, respiratory decline.

The ability to drive and operate machinery

Do not control the vehicle, machine, or other vehicles when taking the drug because the drug can cause sleepiness, loss of agility.

Pregnancy

Pregnant women: consult a doctor before use.

Breastfeeding period

Medicinal interaction

Monoamine oxidase inhibitors (IMAO) and 3 -round antidepressants can be prolonged, increasing anticholinergic effects and sedative effects of antihistamine drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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