Auclanityl 250/31.25mg Tipharco powder for infection treatment (12 packs x 3.8g)

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicilin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not to be destroyed by beta - lactamase, while expanding the antibacterial spectrum of amoxicillin effectively for many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

The bactericidal spectrum of the drug includes:

Gram -positive bacteria:

Air -pretended type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes. Streptococcus Viridans. Staphylococcus aureus, corynebacterium,. Bacillus anthracis, Listeria monocytogenes.

Anaerobic type: Clostridium, peptococcus, peptostreptococcus.

Gram -negative bacteria:

Air -favorite type: Haemophilus Influenzae, Moraxella Catnrhalis, Escherichia Coll, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeea, Neisseria Mensseria Pasteurella Multocida.

Anaerobic type: Baceroides including B. Fragilis.

Strains of anti -drug bacteria: Citrobacter, Entobacter. Morganella, Serratia spp., And Pseudomonas Aeruginosa. Some beta - Lactamase broad spectrum transmitted via plasmid of Klebsiella Pneumoniae, some other Enterobacteriaceae and pseudomonas aeruginosa are also not inhibited by clavulanic acid.

pharmacokinetics

absorption:

Amoxicillin and clavulanic acid are easily absorbed by oral. The concentration of these 2 substances in serum reaches maximum after 1-2 hours of taking the medicine. With a dose of 250 mg (or 500 mg), there will be 5 µg/ml (or 8 - 9 µg/ml) amoxicillin and about 3 µg/ml of clavulanic acid in serum. After 1 hour oral 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 µg/ml of amoxicillin and 3 µg/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals.

Elimination:

55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged through urine in the form of activity. Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Be cautious when using

for patients with manifestations of liver dysfunction: Signs of symptoms of cholestasis jaundice, though rarely occurs when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

For patients with a history of hypersensitivity to penicillins may have severe reactions or deaths.

For people with average or severe renal impairment, attention should be paid to the dosage.

For those who use amoxicillin with redness with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Periodically check the hematology, liver and kidney function during treatment. Distinguished diagnosis is needed to detect cases of diarrhea caused by C. Difficile and fake colitis. There is a high risk of a rash in patients with monon cells.

Patients with phenylketon urinary and patients need to control phenylalanin to be cautious when using chewing tablets or mixed powder containing aspartam due to Aspartam metabolized in the digestive tract into phenylalanin.

The ability to drive and operate machinery

Not applicable, the dosage form is only suitable for children with weight

Pregnancy

Not applicable, the preparation is only suitable for children with weight

The period of breastfeeding

Not applicable, the form of preparation is only suitable for children with weight

Interactive drug

The drug can prolong the bleeding time and coagulation, so it is necessary to be careful for those who are treated with anticoagulants (Warfarin).

nitedipine increases amoxicillin absorption.

Patients with hyperuricemia when using alopurinol along with amoxicillin will increase the ability of amoxicillin.

There may be antagonists between amoxicillin and bactericidal stimulants such as fusidic acid, chloramphenicol, tetracyclin.

Amoxicillin reduces methotrexate secretion, increases toxicity on the digestive tract and hematopoietic system.

Probenecid when taken right before or simultaneously with amoxicillin reduces amoxicillin excretion, thereby increasing blood amoxicillin levels in the blood. However, Probenecid does not affect the sale time, the maximum concentration of the drug in the blood (CMAX) and the area under the curve of drug concentration over time in the blood (AUC) of Clavulanic Acid.