Auclanityl 500/62.5mg Tipharco powder for infection treatment (12 packs x 3.8g)

Dosage form Box of 12 packs x 3.8g
Specifications Clavulanic acid, amoxicilina
Ingredient Tipharco

Ingredient

Composition information	Content
Clavulanic Acid	62.5mg
Amoxicilina	500mg

Uses

indications

AuclanityL 500/62.5mg drug indicated in a short time of the following cases:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media have been treated with conventional antibiotics but does not decrease. E. coli, Klebsiella and Enterrobacter produce: cystitis, urethritis, pyelonephritis (female genital tract infections). Abdominal.

ATC code: J01cro2.

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactamin family with broad bactericidal spectrum for many Gram -positive and gram -negative bacteria due to the synthetic inhibition of bacterial cell walls. But because Amoxicilin is easily decomposed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (many of En Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicilin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not to be destroyed by beta - lactamase, and expand the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and cephalosporins.

Dynamic pharmacokinetics

amoxicillin and clavulanic acid are easily absorbed by oral.

The concentration of these 2 substances in the serum is up to 1-2 hours of taking the medicine. With a dose of 250mg (or 500mg) will have 5µg/ml (or 8 - 9µg/ml) amoxicillin and about 3µg/ml of clavulanic acid in serum. After 1 hour oral 20mg/kg amoxicillin + 5mg/kg Clavulanic acid, there will be an average of 8.7µg/ml of amoxicillin and 3µg/ml of clavulanic acid in serum.

The absorption of the drug is not affected by food and it is best to take it right before meals.

The oral bioactivity of amoxicillin is 90% and of Clavulanic acid is 75%. Half a lifetime of amoxicillin in serum 1-2 hours and of Clavulanic acid is about 1 hour.

55 - 70% amoxicillin and 30-40% clavulanic acid are discharged through urine in the form of activity. Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

Before taking Auclanityl 500/62.5mg Tipharco powder for infection treatment (12 packs x 3.8g)

How to use

AuclanityL 500/62.5mg oral. Should drink at the beginning of eating. Treatment must not exceed 14 days without examination.

Dosage

Adults and children from 40kg or more

Take 1 pack/time, 8 hours/time.

Children under 40kg

Normal dose: Take 20 mg of amoxicillin/kg/day, divided into 3 times, 8 hours apart.

Treatment of otitis media, sinusitis, lower respiratory tract infections and severe bacterial infections, usual doses: 40 mg amoxicillin/kg/day, divided into 3 times, 8 hours apart, for 5 days.

kidney failure

Creatinine clearance:

> 30 ml/minute: No dose adjustment. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, general reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when using a very high doses because clavulanic acid is used in the form of potassium salt.

Overdose treatment: Can use the method of hemolysis so that the drug is from circulation.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using AuclanityL 500/62.5mg drugs often experience unwanted effects (ADR) such as:

Common, ADR> 1/100

diarrhea, rash, itching.

Uncommon, 1/1000

Incretion, nausea, vomiting.

Hepatitis and jaundice, increased transaminase. Can be heavy and last for several months. Itching, erythema, rash.

Rare, ADR

Anaphylaxis reactions, Quincke edema, platelet mitigation, leukopenia, hemolytic anemia, fake colitis, Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning, interstitial nephritis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Auclanityl 500/62.5mg drug contraindicated in the following cases:

allergies to the beta - lactam group (penicillin and cephalosporin).

Be cautious when using

for patients with signs of liver dysfunction

Signs of bile jaundice symptoms occur rarely when taking the drug but may be severe. However, those symptoms often recover and
will end after 6 weeks of stopping treatment.

For patients with a history of hypersensitivity to penicillins may have severe reactions or deaths.

For people with average or severe renal impairment, attention should be paid to the dosage.

For those who use amoxicillin with redness with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Avoid using drugs for pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

Using drugs for women during pregnancy and lactation

Avoid the use of drugs for pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

During breastfeeding can use preparations. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

The effect of the drug on the ability to drive and operate machinery

The drug does not cause drowsiness, so it can be used for driving and operating machinery.

Interactive drug

The drug can cause prolonged bleeding time and coagulation. Therefore, it is necessary to be careful for those who are treating with anticoagulants.

The drug may reduce the effectiveness of the drug to notice to the patient.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.