Augmentin 1g GSK medicine for infections (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Interstitial nephritis, cystitis, skin and soft tissue infection, upper respiratory tract, chronic bronchitis, osteoarthritis

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

indicated

Augmentin 1g is indicated for short -term treatment of infections in the following positions:

Upper respiratory tract infections (ear-nose-ears): tonsillitis, sinusitis, otitis media.

Lower respiratory infections: Exacection of chronic bronchitis, lobe pneumonia and bronchitis Teeth: tooth abscess.

Use drugs according to the instructions of the official antibiotic prescription and data on the sensitivity of local bacteria.

Pharmacokology

Augmentin 1g is an antibiotic with a wide antibacterial spectrum, especially against common bacteria in the community and hospitals. Cluavulanate's beta-lactamse enzyme inhibits amoxicillin's antibacterial spectrum, including many strains resistant to other beta-lactam antibiotics.

pharmacokinetics

absorption:

Amoxicillin and clavulanic acid are well absorbed and fast through oral when taken at the beginning of the meal. After drinking, both achieved approximately 70%.

Distribution:

About 25% of total clavulanic acid in plasma and 18% amoxicillin total in plasma binding to protein.

After intravenous injection, both are found in gallbladder, abdominal tissue, skin, muscle tissue, fluid and abdominal fluid, bile and latex. Amoxicillin is not much distributed in cerebrospinal fluid.

Metabolism:

Amoxicillin eliminates part of the urine in the form of inactivated penicilloic acid with an equivalent of 10 to 25% of the initial dose.

Clavulanic acid metabolizes in humans and eliminates urine and feces in the form of CO2 in exhaled gas.

Era:

Amoxicillin is excreted mainly through the kidneys, while clavulanic acid eliminates the mechanism through both the kidneys and external kidneys.

amoxicillin/clavulanic acid has an average 1 hour waste sale time.

Before taking Augmentin 1g GSK medicine for infections (2 blisters x 7 tablets)

How to use

Patients should swallow both tablets and do not chew. If you need a pair of tablets and pills and do not chew.

Should take the medicine at the beginning of the meal to absorb the optimal drug and minimize the possibility of gastrointestinal intolerance.

Do not treat more than 14 days without testing.

Dosage

conventional dose treatment

Adults and children over 12 years old:

Mild up to medium infection: 625mg x 2 times/day.

Severe infections: 1g x 2 times/day.

It is not recommended to use Augmentin 625mg and 1g for children 12 years old and younger.

Patients with renal failure (adults):

should only use Augmentin 1g for patients with glomerular filtration> 30ml/min.

Patients with medium renal failure (Creatinine clearance 10 - 30ml/min) and severe renal failure (Creatinine clearance

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Meet the urinary amoxicillin crystal in some cases leading to renal failure.

Augmentin 1g can be removed from the circulatory cycle.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Augmentin 1g, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: diarrhea, nausea, vomiting;

Infections and architects: Candida infections on skin and mucosa.

Uncommon, 1/1000

Nervous system: dizziness, headache;

digestive system: indigestion;

Skin and subcutaneous tissue: skin rash, itching, urticaria;

Liver, bile: Moderate increase AST and/or Al.

Instructions on how to handle ADR

Vomiting usually appears more when taking high doses. If there are signs of reactions on the gastrointestinal tract, you can take the drug at the beginning of the meal to reduce these reactions. When encountering other side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

contraindicated drugs in the following cases:

Patients with a history of hypersensitivity to beta-lactam (penicillin, cephalosporin).

Patients with a history of jaundice/liver dysfunction related to augmentin.

Be cautious when using

Before the beginning of treatment with 1g Augmentin should ask carefully the history of hypersensitivity reaction to penicillin, cephalosporin or other allergens.

Avoid using augmentin if suspected of mononucleemocal hypernage due to the appearance of measles rash related to this condition after using amoxicillin.

For long -lasting use can sometimes cause non -sensitive bacteria.

Palm colitis may be encountered after antibiotics with mild to life -threatening severity. Therefore, this diagnostic consideration is very important in patients with diarrhea during or after antibiotics. If diarrhea is a lot or prolonged or a patient with abdominal pain should stop treatment immediately and check the patient.

Rarely about prothrombin time (Inr) in patients with Augmentin and anticoagulants used orally. Monitoring when prescribing simultaneously with anticoagulants, the dose of oral anticoagulants can be adjusted to maintain the desired anticoagulant level.

Be cautious when using the drug in patients with signs of liver dysfunction.

Convulsions can occur in patients with renal function or high doses.

Advise patients to maintain enough water and the amount of urine excreted during the high doses of amoxicillin use to reduce the possibility of the occurrence of urinary amoxicillin crystals.

The ability to drive and operate machinery

has not observed the unwanted effect on the ability to drive and operate machinery.

Pregnancy

should not take medication during pregnancy, especially in the early stages of pregnancy, unless the doctor's special request is available.

breastfeeding period

can use Augmentin 1g during breastfeeding. Except for the risk of hypersensitivity, related to the excretion of a very small amount of breast milk, there is no adverse side effect for breastfeeding children.

Medicinal interaction

used with probenecids reduces the secretion of amoxicillin through the renal tubules increases and prolongs the concentration of amoxicillin in the blood.

Concentrated with Allopurinol while treating amoxicillin can cause an increase in the likelihood of allergic reactions on the skin.

Augmentin shared with 1g with other antibiotics may affect the intestinal bacteria, which leads to the reduction of re -absorption of estrogen, reducing the effectiveness of oral contraceptives used in combination.

Storage

Store in closed packaging, dry place, temperature below 30ºC.

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