AUGMEX DUO Korea United treatment for bronchitis, cystitis (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, sore throat, sinusitis, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

indications

Augmex Duo drug is indicated in the following cases:

Acute and chronic bronchitis and chronic, bronchitis - pulmonary and pulmonary lobes, pleural pleura, pulmonary abscess, tonsillitis, sinusitis, otitis media;

Cystitis , urinary tract, nephritis - pyelonephritis;

Infections due to miscarriage, obstetric blood infections, pelvic cell inflammation, oral hypoglycemia, gonorrhea ;

boils and abscesses, cellitis, wound infections, abdominal infections;

Vectoritis; osteomyelitis;

Blood infection;

Postoperative infection.

Pharmacy

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam family with wide bactericidal spectrum for many gram -positive and gram -negative bacteria due to the synthetic inhibition of bacterial cells. Amoxicillin is easily destroyed by beta - lactamase, so it does not work for bacterial strains producing these enzymes (multiple enzyme strains and H. Influenzae).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicillin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillin and cephalosporin.

Clavulanic acid helps Amoxicillin not be destroyed by beta - lactamase, while expanding the antibacterial spectrum of amoxicillin effectively for many common bacteria that have been resistant to amoxicillin, resistant penicillin and cephalosporins.

antibacterial spectrum:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic type: Clostridium, peptococcus, peptostreptococcus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, PasteRae Multocida.

anaerobic type: Bacterioides including B. Fragilis.

Amoxicillin and Clavulanat are easy to absorb through oral. The absorption of the drug is not affected by food and it is best to drink right before the meal.

Distribution - Metabolism:

The concentration of these 2 substances in serum is maximum after 1-2 hours of taking the drug. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%.

Era:

The half -life of amoxicillin in serum is 1-2 hours and of clavulanic acid is about 1 hour. 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking AUGMEX DUO Korea United treatment for bronchitis, cystitis (2 blisters x 10 tablets)

How to use

take the tablet with water, no chewing. It is best to drink right before meals.

Dosage

Adults: The usual dosage in adults is 1 tablet, drink every 12 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In the case of poisoning, symptomatic treatment is done based on the monitoring of electrolytes and applying other appropriate auxiliary measures. The drug is eliminated from the circulatory method by hemorrhage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using AUGMEX Duo, you may experience unwanted effects (ADR).

Hypersensitivity:

Rarely causes rash (usually light and transient) and urticaria (related to hypersensitivity to penicillin, need to stop taking the drug).

Stomach - intestines:

can cause diarrhea , fake colitis, indigestion , nausea, vomiting, stomatitis and candidiasis.

Nausea (rare) is often related to high doses of drugs. These side effects may be reduced when taking the drug right before meals.

DA:

Rarely causes a variety of erythema, Stevens - Johnson syndrome, Lyell syndrome, angioedema, dermatitis.

If the above symptoms occur, it is necessary to stop taking the drug.

liver:

Occasionally cause AST, ALT, ALP.

rarely cause hepatitis and jaundice.

These reactions occur more often in adults, elderly people and men. Liver dysfunctions are often recovered, rarely severe liver dysfunction.

Hematology:

can cause anemia hemolytic, thrombocytopenia, thrombocytopenia, eosinophilia preferred eosin, leukemia, leukemia, granulocytes.

If the above symptoms occur, it is necessary to stop taking the drug.

Kidney:

rarely cause severe impaired renal function such as acute renal failure and interstitial nephritis .

Need to closely monitor the patient and periodically assess the patient's kidney function. If any abnormal symptoms occur, it is necessary to stop the drug and/or conduct appropriate treatment.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

AUGMEX DUO drug is contraindicated in the following cases:

Patients with hypersensitivity to penicillin.

Patients with mononoculatoculus hyperlemen.

Patients who have a history of jaundice or liver dysfunction are related to the use of penicillin.

Be cautious when using

Patients with severe liver failure.

Patients with medium to severe kidney failure (normal doses need to be adjusted due to drugs with long half -life).

Patients have a history of hypersensitivity to penicillin and cephalosporins.

Patients with relatives are sensitive to the cause of allergies such as bronchial asthma, rash and urticaria ...

Elderly patients and people are in poor health (these patients need to be monitored closely due to vitamin K deficiency).

Severe hypersensitivity reactions and sometimes life -threatening (anaphylactic reaction) and angioedema may occur in people treated with penicillin. These reactions are likely to occur in people with a history of hypersensitivity to penicillin and/or in people with a history of sensitivity to allergens. These reactions often occur more in drug users by oral, but also recorded cases related to oral penicillin.

Slowly treatment occasionally causes superinfection of bacterial strains that are not sensitive to drugs. Therefore, when treatment lasts more than 14 days, it is necessary to closely monitor the patient to promptly detect these signs and symptoms. Signs and symptoms of harmful reactions have been recorded during treatment as well as within 6 weeks after stopping treatment.

Use AugMex Duo by oral route to increase the concentration of amoxicillin in the urine. This can cause false positive reactions when conducting a test for glucose in the urine with clinitest, benedict solution or fehling solution.

The ability to drive and operate machinery

No report. Need to consult a doctor or medical staff.

Pregnancy

Animal studies show that the drug is not harmful to the fetus. However, the drug should not be used in pregnant women or likely to get pregnant unless it is really necessary, due to the safety of this object has not been established. Especially should not use the drug in the first 3 months of pregnancy.

Breastfeeding period

A small amount of drugs can be through breast milk.

Drug interaction

Probenecid reduces the elimination through the renal tubules of amoxicillin. Using drugs simultaneously with probenecid can increase and prolong the concentration of amoxicillin in the blood.

Simultaneous use of ampicillin and allopurinol basically increases the ratio of rash in the sick compared to when using ampicillin alone. It is still unknown that the ability to cause ampicillin rash is due to the presence of allopurinol or for hyperuricemia in the patients.

Do not use AUGMEX duo with disulfiram.

prolonged bleeding and increasing blood clotting time has been recorded very rare in drug users. Therefore, it is necessary to be cautious when taking drugs in humans being treated with anticoagulants.

The drug may reduce the effects of oral contraceptives, so it is necessary to notify the patient when using this drug.

Storage

Store in closed packaging, avoid moisture, in a dry and cool place.

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