Augtipha 1g tipharco treatment for infection (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, skin infections and soft tissue, acute bronchitis, chronic bronchitis, bone inflammation

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

Indications

Augtipha drug is indicated in the following cases:

Heavy respiratory infections: tonsillitis , sinusitis , otitis media have been treated with conventional antibiotics but does not decrease. and Man, pneumonia - Bronchial. Bone bacteria and joints: osteomalitis bacterial cells. But because Amoxicilin is easily decomposed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (many of En

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicilin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins. Clavulanic acid itself has very weak antibacterial effects. Clavulanic acid helps amoxicillin not to be destroyed by beta - lactamase, while expanding the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant to other penicillins and cephalosporins.

pharmacokinetic

amoxicillin and clavulanic acid both absorbed easily by oral. The concentration of these 2 substances in serum reaches maximum after 1-2 hours of taking the medicine. The absorption of the drug is not affected by food and it is best to drink right before meals.

AMOXICillin's oral bioactivity is 90% and of clavulanic acid is 75%.

The half -life of amoxicilin in serum 1-2 hours and of Clavulanic acid is about 1 hour.

55 - 70% amoxicillin and 30-40% clavulanic acid are discharged through urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Augtipha 1g tipharco treatment for infection (2 blisters x 10 tablets)

How to use

Take at the beginning of eating.

Treatment must not exceed 14 days without examination.

Dosage

calculated by amoxicillin content in the drug.

adults and children 40kg or more

Take 1 tablet, 8 hours/time, 5 days.

kidney failure

Creatinine clearance:

> 30 ml/minute: No dose adjustment.

15 - 30 ml/min: Normal dose, 12 - 18 hours/time.

5 - 15 ml/minute: Normal dose, 20 - 36 hours/time.

Hemodiatro: 1 tablet between each time of appraisal and 1 tablet after each appraisal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, general reactions occur depending on the hypersensitivity of each individual.

The risk is definitely increased with potassium when taking very high doses because clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from circulation.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Augtipha, you may experience unwanted effects (ADR).

Common: diarrhea , foreign rash, itching. Hepatitis and jaundice, increased transaminase. Can be heavy and last for several months. Itching, erythema, rare rash. Unwanted use when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Augtipha drug is contraindicated in the following cases:

allergies to the beta - lactam group (penicillin and cephalosporin).

Caution when using

For patients with manifestation of liver dysfunction: Signs of symptoms of jaundice are rare when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

For patients with a history of hypersensitivity to penicillin may have severe reactions or death.

For people with average or severe renal impairment, attention should be paid to the dosage.

For those who use amoxicillin with redness with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

The ability to drive and operate machinery

The drug does not cause drowsiness, so it can be used for driving and operating machinery.

Pregnancy

Avoid the use of drugs for pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

Breastfeeding period

During breastfeeding can use preparations. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Medicinal interaction

Probenecid : Probenecid reduces the excretion of amoxicillin in the renal tubules. Simultaneous use of probenecid with amoxicillin and clavulanic acid can increase the concentration of amoxicillin in the blood. Unable to use simultaneously.

Oral anticoagulants: Concomitance oral anticoagulant drug with amoxicillin and clavulanic acid can cause abnormal prolonged time prothrombin time. Need to adjust the oral anticoagulant dose.

Allopurinol : simultaneous use of allopurinol with amoxicillin significantly increases the ratio of rash in the patient.

Oral contraceptives: Amoxicillin and clavulanic acid can affect the intestinal bacteria, leading to reducing estrogen reabsorption and reducing the effectiveness of oral contraceptives in combination with estrogen/progesterone.

Amoxicillin can lead to a false positive reaction in the test of glucose concentration in urine.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Expiry date: 36 months from the date of production.

Do not use drugs when expired on the label.

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