Augtipha 625mg tipharco treatment for infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Skin and soft tissue infections, acute bronchitis, upper respiratory tract infections, chronic bronchitis, pneumonia, osteoarthritis

Ingredient

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Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

indications

Augtipha 625 mg is indicated in the following cases:

Treatment in a short time the following cases:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media have been treated with conventional antibiotics but does not decrease. E. coli, Klebsiella and Enerobacter produce: cystitis, urethritis, pyelonephritis (female genital tract infections). Abdominal. But because Amoxicilin is easily decomposed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (many of En

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicilin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not to be destroyed by beta - lactamase, while expanding the antibacterial spectrum of amoxicillin effectively for many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

Dynamic pharmacokinetics

amoxicillin and clavulanic acid are easily absorbed by oral. The concentration of these 2 substances in serum reaches maximum after 1-2 hours of taking the medicine. With a dose of 500 mg will have 8 - 9 PG/ml of amoxicillin and about 3 mcg/ml of clavulanic acid in serum. After 1 hour oral 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 mcg/ml of amoxicillin and 3 mcg/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals.

The oral bioactivity of amoxicillin is 90% and of Clavulanic acid is 75%. Half a lifetime of amoxicillin in serum 1-2 hours and of Clavulanic acid is about 1 hour.

55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged through urine in the form of activity. Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

Before taking Augtipha 625mg tipharco treatment for infections (2 blisters x 10 tablets)

How to use

drink at the beginning of eating. Treatment must not exceed 14 days without examination.

Dosage

Dosage calculated by amoxicillin content in the drug.

Adults and children from 40 kg or more

Take 1 tablet, 8 hours/time, 5 days.

kidney failure

Creatinine clearance is over 30 ml/min: No dose adjustment.

Creatinine clearance 15 - 30 ml/min: Normal dose, 12-18 hours/time.

Creatinine clearance 5 - 15 ml/min: Normal dose, 20-36 hours/time.

Creatinine clearance below 5 ml/minute: Normal dose, 48 hours/time.

Artificial dialysis

1 tablet between each time of appraisal and 1 tablet after each appraisal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, general reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when taking a very high dose because clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Augtipha 625 mg, you may experience unwanted effects (ADR).

Common

diarrhea, foreign rash, itching.

Less

Incretion, nausea, vomiting. Hepatitis and jaundice, increased transaminase. Can be heavy and last for several months. Itching, erythema, rash.

Rare

Anaphylaxis reaction, Quincke, platelet reduction, leukopenia, hemolytic anemia, fake colitis, Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning, interstitial nephritis.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Augtipha 625 mg contraindicated in the following cases:

allergies to the beta - lactam group (penicilin and cephalosporin).

Be cautious when using

for patients with manifestation of liver dysfunction: Signs of symptoms of cholestasis jaundice, though rarely occurs when taking the drug but is severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

For patients with a history of hypersensitivity to penicillins may have severe reactions or deaths.

For people with average or severe renal impairment, attention should be paid to the dosage.

For those who use amoxicillin with redness with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Avoid using drugs for pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The ability to drive and operate machinery

The drug does not cause drowsiness, so it can be used for people who are driving and operating machinery.

Pregnancy

avoid using drugs for pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The period of breastfeeding

during breastfeeding may be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Interactive drug

The drug can cause prolonged bleeding time and coagulation. Therefore, it is necessary to be careful for those who are treating with anticoagulants.

The drug can reduce the effectiveness of oral contraceptives, so it is necessary to notify the patient in advance.

Storage

Put in a dry place, avoid light. Temperature below 30 ° C.

Other drugs

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