Augxicine 250mg/31.25mg Vidipha treat tonsillitis, sinusitis (10 packs x 0.8g)

Dosage form Box of 10 packs x 0.8g/package
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, pharyngitis, sinusitis, urinary tract infections, genital infections, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

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Composition information	Content
Amoxicillin	250mg
Clavulanic Acid	31.25mg

Uses

indications

Augxicine drugs are indicated for treatment in short time cases of sensitive bacteria infections such as:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media have been treated with conventional antibiotics but does not help.

Lower respiratory infections by H. Influenzae strains and Branhamella CatVrbalis produce beta - lactamase.

Acute and chronic bronchitis, pneumonia - bronchial.

Severe urinary - genital infections by strains E.coli, Klebsiella and Enterobacter produced: cystitis, urethritis, pyelonephritis (female genital tract infections).

Skin infections and soft tissue: pimples, abscesses, wound infections.

Bone and joint infections: Bone inflammation.

Dental infections: tooth abscess.

Pharmacology

Amoxicillin is a semi -synthetic antibiotic of the Beta - Lactam family, with wide bactericidal spectrum for many gram -positive and gram -negative bacteria due to the synthetic inhibition of bacterial cells. But because Amoxicilin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (many eninelobacieriaceae and hemophilus influenzae). Clavulanic acid due to the fermentation of Streptomyces Clavuligerus has a beta - lactam structure similar to penicillin, capable of inhibiting beta -lactamase due to the majority of Gram -negative bacteria and staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmids that resist penicillin and cephalosporins.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some entobacter strains and providentia resistant drugs, and staphylococcus aure against Methicilin are also resistant to this drug. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not being destroyed by beta - lactamase, and expanding the antibacterial spectrum of amoxicillin effectively with many common bacteria that have resisted amoxicillin, resistant penicillins and cephalosporins.

It is possible to see Amoxicilin and Clavulanat as an antibacterial poison for pneumococcus, streptococcus beta beta, Staphylococcus (penicillin sensitive strains are not affected by penicilinase), Haemophilus Infienza and Branhamella Catatrhalis, including strong Beta - LaCTama. In short, the antibacterial spectrum of the drug includes:

Gram -positive bacteria

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogens. Clostridium, peptococcus, peptostreptococcus.

Gram -negative bacteria

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, PasteRae Multocida. The concentration of these two substances in serum is maximum after 1-2 hours of taking the medication. With a dose of 250 mg (or 500 mg) will have 5 micrograms/ml (or 8 - 9 micrograms) amoxicillin and about 3 micrograms/ml of clavulanate acid in serum.

After an hour oral 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals.

The oral bioactivity of amoxicillin is 90% and of Clavulanic acid is 75%. The half -life of amoxicillin in serum is 1-2 hours and of Clavulanìc acid is about 1 hour.

55% - 70% amoxicillin and 30-40% clavulanic acid are discharged through urine in the form of activity. Probenecid extends the excretion time of amoxicilin but does not affect the elimination of clavualnic acid.

Before taking Augxicine 250mg/31.25mg Vidipha treat tonsillitis, sinusitis (10 packs x 0.8g)

How to use

Take medicine at the beginning of eating to minimize the phenomenon of non -intolerance in the stomach - intestines.

Do not take medicine for more than 14 days without checking the treatment.

Dosage

Amoxicillin -related dose.

Children over 30 months old have normal kidney function

80mg/kg/day divided 3 times, not used exceeding 3 g/day.

Children over 30 months of kidney failure

Adjust the dose according to creatinine clearance.

greater than 30 ml/minute: No dose adjustment.

from 10 to 30 ml/minute: no more than 15 mg/kg of weight/a dose, 2 times daily.

less than 10 ml/minute: no more than 15 mg/kg of weight/day.

Hematoparoology

15 mg/kg of weight/day; Add 15 mg/kg of weight during and after hemolysis.

Adults

250 mg/time, 8 hours/time. Severe infections and respiratory infections: 500 mg every 8 hours, for 5 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? However, in general, the acute reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when using a very high doses because clavulanic acid is used in the form of potassium salt.

Can use the method of hemolysis so that the drug is from circulation.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Augxicine, you may experience unwanted effects (ADR).

Common, ADR> 1/100

diarrhea; External, itching.

Uncommon, 1/1000

Incretion increases; nausea, vomiting; Hepatitis and jaundice, increased transaminase. May be heavy and last for several months; Itching, erythema, rash.

Rare, 1/10000

Anaphylactic reaction, edema; A mitigation of platelets, leukopenia, hemolytic anemia; fake colitis; Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning; interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Augxicine drugs contraindicated in the following cases:

allergies to the beta - lactam group (penicillins and cephalosporins).

Pay attention to the ability to cross allergies to beta - lactam antibiotics as cephalosporin.

Pay attention to patients with a history of jaundice/liver dysfunction due to the use of amoxicilin and clavulanate or penicilin because clavulanic acid causes increased cholestatic risk in the liver.

Be cautious when using

Patients with signs of liver dysfunction: Signs and symptoms of cholestasis jaundice, though rarely occurs when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

Average or severe renal failure should pay attention to the dosage.

Patients with amoxicillin redness with lymphadenopathy.

Take prolonged drugs to develop anti -drug bacteria.

Patients with urinary phenylceton.

The ability to drive and operate machinery

Not recorded.

Pregnancy

Because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The period of breastfeeding

During breastfeeding, the preparation may be used. The drug is not harmful to breastfeeding, unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Interactive drug

The drug can cause prolonged bleeding time and coagulation. Therefore, it is necessary to be careful for people who are being treated with anticoagulants.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient in advance.

Storage

Store in a cool dry place, avoid light, at temperatures below 30ºC.

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Disclaimer

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