Augxicine 625 medicine for infections (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Clavulanic acid, amoxicilina
Ingredient Vidipha

Ingredient

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Composition information	Content
Clavulanic Acid	125mg
Amoxicilina	500mg

Uses

indications

The drug is used for treatment in a short time cases of sensitive bacterial infections such as:

Severe upper respiratory infections: tonsillitis, sinusitis, otitis media have been treated with common antibiotics but does not help.

Lower respiratory infections by H.influenzae strains and Branhamella Catnrbalis produce betalactamase. Acute and chronic bronchitis, pneumonia - bronchial.

Urinary - genital heavy bacterial infections by E.coli strains, Klebsiella and Enerobacter produce betalactamase: cystitis, urethritis, pyelonephritis, female genital tract infections.

Skin and soft tissue infections: pimples, abscesses, wound infections.

Bone and joint infections: Bone inflammation.

Dental infections: to alveolar abscess.

Pharmacology

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam family that has a broad bactericidal spectrum for many gram -lactam gram -positive and gram -negative micro -sound due to the synthetic inhibition of bacterial cells. But because Amoxicillin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenzae).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, which has a beta - lactam structure similar to penicilin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasmids that resist penicillin and cephalosporins.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some entobacter strains and providentia anti -drugs, and staphylococcus aure against this drug. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps Amoxicillin not be destroyed by beta - lactamase, and expand the antibacterial spectrum of amoxicillin effectively with many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

It is possible to see Amoxicillin and Clavulanate are bactericidal for pneumoccus, streptococcus beta beta, Staphylococcus (penicilin sensitive strains are not affected by penicillinase), Haemophilus Influenzae and Branhamella Catatrhalis, including strong products. lactamase. In short, the bactericidal spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic type: Clostridium, peptococcus, peptostreptococcus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, Pasteurae Multocida.

Anaerobic type: Bacterioides including B.fragis.

Dynamic pharmacokinetics

Amoxicillin and Clavulanate both absorb easy through oral. The concentration of these two substances in serum is maximum after 1-2 hours of taking the medication. With a dose of 250mg (or 500mg), there will be 5 micrograms/ml (or 8 - 9 micrograms/ml) amoxicillin and about 3 micrograms/ml of clavulanic acid in serum. After an hour oral 20mg/kg amoxicillin + 5mg/kg Clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals.

Amoxicillin's oral bioactivity is 90% and of Clavulanic acid is 75%. The half -life of amoxicillin in serum is 1-2 hours and of clavulanic acid is about 1 hour.

55% - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Augxicine 625 medicine for infections (4 blisters x 7 tablets)

How to use

Take medicine at the beginning of eating to minimize the phenomenon of non -intolerance in the stomach - intestines.

Do not take medicine for more than 14 days without checking the treatment.

Dosage

Adults:

For severe infections and respiratory tract infections: 1 tablet 500mg every 8 hours, for 5 days.

Dosage of children from 40 kg or more: Take adult dose.

Children under 40 kg of weight: not suitable for using this form of preparation.

kidney failure:

When kidney damage is available, the dose and/or the number of times must be changed to respond to kidney damage.

If creatinine clearance is greater than 30ml/minute: The dose does not need to change. If the clearinine clearance 15 - 30ml/min: the usual dose for 12 -18 hours apart. If creatinine clearance 5 - 15ml/min, the usual dose for each other 20 - 36 hours, and adults with creatinine clearance below 5ml/minute: for the usual dose 48 hours/time.

If dialysis, for 1 tablet of 500mg (containing 500mg of amoxicillin and 125mg of clavulanic acid) between the time of each time of fertilization and an additional 1 tablet of 500mg after each appraisal.

What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

Common: diarrhea; External, itching.

Uncommon: Incretion of eosinophilia; nausea, vomiting; Hepatitis and jaundice, increased transaminase. May be heavy and last for several months; Itching, erythema, rash.

Rare: Anaphylaxis reactions, edema; A mitigation of platelets, leukopenia, hemolytic anemia; fake colitis; Steven - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning; interstitial nephritis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

allergies to the beta - lactam group (penicilin and cephalosporins).

Pay attention to cross -allergies with beta -lactam antibiotics as cephalosporins.

Pay attention to patients with a history of jaundice/liver dysfunction due to the use of amoxicillin and clavulanate or penicilin because clavulanic acid causes increased cholestatic risk in the liver.

Be cautious when using

Patients with signs of liver dysfunction: Signs and symptoms of cholestasis jaundice, though rarely occurs when taking the drug but may be severe. However, those symptoms are often recovered and will end after 6 weeks of stopping treatment.

Average or severe kidney failure needs to pay attention to the dosage.

Patients with amoxicillin are reddened with lymphadenopathy.

Take prolonged drugs to develop anti -drug bacteria.

Patients with urinary phenylceton.

The effect of the drug on the ability to drive and operate machinery

consult a doctor before using the product for the driver and operate machinery.

Use drugs for women during pregnancy and nursing mothers

Pregnant women: Because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

Lactating women: During breastfeeding can use preparations. The drug is not harmful to breastfeeding, unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Consult your doctor before using the product for pregnant and nursing women.

Interactive drug

The drug can cause prolonged bleeding time and coagulation. Therefore, it is necessary to be careful for patients being treated with anticoagulants.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient in advance.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

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