Augxicine medicine 500mg/62.5mg Jersey treat tonsillitis, sinusitis (10 packs x 1000mg)

Dosage form Box of 10 packs x 1g/package
Specifications Amoxicillin, clavulanic acid
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, genital infections, acute bronchitis, chronic bronchitis

Ingredient

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Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	62.5mg

Uses

Indications:

Augxicine 500 mg/62.5 mg is indicated in the following cases:

Amoxicillin and potassium clavulanate preparations are used for treatment in a short time (less than 14 days) cases of infections caused by the products produced by beta - lactamase are not responded to treatment with poisonous aminopenicilin and sensitive to drugs:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media.

Lower respiratory infections: The outbreak of chronic bronchitis, pneumonia sufficient in the community.

Severe infection of urinary tract - genital: cystitis, urethritis, pyelonephritis.

Skin infections and soft tissue: pimples, insects, abscess, wound infections, cellular inflammation.

Bone and joint infections: Bone inflammation.

Pharmacology

Amoxicillin is a semi -synthetic penicillin (beta antibiotic - lactam), inhibiting one or more enzymes (often called penicillin bonding proteins, PBP) in the bacterial peptidoglycan biosynthesis of bacteria, this is an indispensable ingredient in bacteria. The inhibition of peptidoglycan biosynthesis leads to weakened bacterial cell wall walls, which often lead to cell destruction and death.

Amoxicillin is easily decomposed by beta - lactamase generated by anti -drug bacteria and thus the amoxicillin spectroscopy used alone does not include bacteria that produce these enzymes.

Clavulanic Acid is a beta - lactam related structural with penicillin. It indifferent to some beta - lactamase enzymes thus prevents Amoxicillin inactivity. Clavulanic Acid alone has no useful antibacterial effect on clinical.

Common sensitive bacteria:

Aerobic Gram -positive bacteria: Enterococcus Faecalis, Gardnerella Vaginalis, Staphylococcus aureus (sensitive to methicillin), Staphylococci without enamel coagulase (sensitive to methicillin), Streptococcus agalactiae, Streptococcus pneumoniae,,, streptococcus pneumoniae Streptococcus Pyogenes and other Beta blood -tanning streptococci, streptococcus viridans.

anaerobic bacteria: Bacteroides Fragilis, Fusobacterium nucleatum, Prevotella spp.

Two main resistance mechanisms with amoxicillin/ clavulanic acid are: inactivated by Beta - Lactamases secretion is not inhibited by Clavulanic Acid, including B, C and D. PBP changes, reducing the affection of antibacterial agents to the target. The permeability of bacteria or pumping mechanism is the cause or contributing to the resistance of bacteria, especially in gram -negative bacteria.

Some strains have drug resistance:

Aerobic Gram -positive bacteria: Enterococcus Faecium.

Aerobic Gram -negative bacteria: Escherichia Coli, Klebsiella Oxytoca, Klebsiella Pneumoniae, Proteus Mirabilis, Proteus Vulgaris.

Bacteria resistant to drugs:

Aerobic gramy bacteria: Acinetobacter sp.

Other bacteria: Chlamydophila Pneumoniae, Chlamydophila Psittaci, Coxiella Burnetii, Mycoplasma Pneumoniae.

Dynamic pharmacokinetics

absorption

Amoxicillin and Clavulanic Acid, are completely separated in water solutions in physiological pH. Both ingredients are easily absorbed by oral. Absorption of amoxicillin and clavulanic acid optimizes when taken at the beginning of the meal. After drinking, bioavailability of amoxicillin and clavulanic acid is about 70%. The concentration absorption chart of the two components is the same in plasma and the time to reach the maximum drug concentration (TMAX) in each case is about an hour.

Distribution

About 22 - 30% Clavulanic acid and 17-20% amoxicillin binds to plasma proteins. Amoxicillin's distribution voltage is about 0.3 - 0.4 l/kg and of clavulanic acid is about 0.2 l/kg.

After drinking, both amoxicillin and clavulanic acid are distributed into the lungs, pleural fluid and peritoneal fluid, passing through the placenta. A small amount of pills found in sputum, saliva as well as in breast milk. When the meninges are not inflamed, the concentration of drugs in cerebrospinal fluid is very low, but the larger amount is achieved when the meninges are inflamed.

Metabolism

Amoxicillin is partially excreted in urine into penicilloic acid, which is not active in equivalent to 10-25% of the initial dose. Clavulanic acid is metabolized in the body and eliminated through feces and urine and in the form of carbon dioxid in emissions.

Elimination

Amoxicillin is excreted mainly through the kidneys, while clavulanic acid is excreted through both kidney - and no kidney mechanisms. Amoxicillin/Clavulanic acid has an average half -life of about an hour and an average creatinine clearance of about 25 l/hour in people with normal kidney function. About 60 - 70% amoxicillin - and about 40 - 65% Clavulanic acid are discharged in urine in the form of unchanged within 6 hours after taking single doses of amoxicillin and potassium clavulanate.

Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

Before taking Augxicine medicine 500mg/62.5mg Jersey treat tonsillitis, sinusitis (10 packs x 1000mg)

How to use

Used by oral, drink at the beginning of eating to minimize the phenomenon of non -intolerance of the stomach - intestines.

Do not take the drug for more than 14 days without checking, reviewing the treatment. The dosage is usually calculated by the content of the total amoxicillin and clavulanic acid.

Put the powder in 10-15ml of cool boiled water (about 2-3 teaspoons), stir and drink immediately.

Dosage

Adults:

Mild up to medium -sized infections: 2 Augxicine 500 mg/62.5 mg (1000 mg/125 mg) x 2 times/day.

Dosage is calculated by age or mg/kg/day.

Children weighing 40kg or more: using the same dose as adults. Some types of bacterial infections (for example, osteomyelitis) need longer treatment time.

No dose adjustment, dose as adults. If signs of renal failure, dose adjustment should be adjusted by patients with renal failure.

kidney failure

No dose adjustment in patients with creatinine clearance> 30 ml/min.

In patients with clearance

Hematopalyst

This drug should only be used for patients with creatinine clearance> 30 ml/min.

Hepatic failure

Be cautious when prescribing this drug, should periodically check the liver function.

Not enough data to give recommended dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Abdominal pain, vomiting and diarrhea, water and electrolyte balance disorders, convulsions, rash, agitation or drowsiness. Crystal pisses in some cases that lead to kidney failure has been reported.

Handling

Need to stop the drug immediately. Symptomatic treatment and support. It is necessary to provide enough water and electrolytes to the body to maintain the urinary tract and reduce the risk of crystalline urination. Can use hemolysis method to remove amoxicillin and clavulanic acid from circulation.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Augxicine often has unwanted effects (ADR).

Common (ADR> 1/100)

Digestive: diarrhea, nausea, vomiting.

Blood: Acidic white blood cells. Can be severe and last for a few months.

Systemic body: Anaphylaxis reaction, edema.

Skin: Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Too hypersensitivity to the beta - lactam group (penicillin, cephalosporin, carbapenem or monobactam) or any ingredients of the drug.

Patients with a history of jaundice/liver dysfunction due to amoxicillin and potassium clavulanate (due to clavulanic acid that increases the risk of cholestasis in the liver).

Precautions when used

For extension of the drug that can cause events in the liver, especially in men and the elderly, prolonged use can cause excessive development of non -sensitive bacteria strains. Cephalosporin and other allergens. The drug should not be used to treat S.pneumoniae resistant penicillin. Skin. This reaction needs to be stopped and not used amoxicillin again, when visiting medical examination and treatment, it is necessary to notify health workers on this issue. Prothrombin has been reported when using amoxicillin/potassium clavulanate. It is necessary to monitor the appropriate prothrombin time when used simultaneously with oral anticoagulants. Adjust the dose of oral anticoagulant drugs to maintain the desired concentration if necessary. Because finding glucose with reducing agents can be positive. Phenylalanin, people with urinary phenylceton should not be used.

The ability to drive and operate machinery

Caution should be cautious when driving or operating machinery due to drugs can cause unwanted effects: allergic reactions, dizziness, headache, convulsions, fatigue.

Pregnancy

Experimental research on the reproductive process of mice proved when using oral preparations and injections at a dose larger than 10 times the dosage for humans did not cause deformities. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

Breastfeeding period

During breastfeeding can use preparations. The drug is not harmful to breastfeeding, unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Medicinal interaction

The drug can cause prolonged bleeding and blood clotting time. Therefore, it is necessary to be careful for those who are treated with anticoagulic drugs (Warfarin). Amoxicillin will increase the ability of amoxicillin.

Probenecid when taken right before or simultaneously with amoxicillin reduces amoxicillin elimination, thereby increasing the concentration of amoxicillin in the blood. However, Probenecid does not affect the sale time, the maximum concentration of the drug in the blood (CMAX) and the area under the curve of drug concentration over time in the blood (AUC) of Clavulanic Acid. (MPA) About 50% after starting oral amoxicillin combined with clavulanic acid. The change of concentration before the dose may not accurately show changes in the overall MPa exposure level.

Storage

Leave a cool dry place, avoid light, avoid moisture, temperature below 30⁰C.

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