AusVair 75 medicine for inflammation, peripheral neuralgia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Pregabalin
Ingredient BRV Healthcare Company Limited

Ingredient

Composition information	Content
Pregabalin	75mg

Uses

indications

AusVair 75 drug is indicated in the following cases:

Pain due to neurological causes: peripheral neuritis (due to diabetes, after herpes).

coordinates with anti -convulsions to treat local epilepsy in adults.

Disrail anxiety disorders.

muscle pain caused by fibrosis. The exact mechanism of action has not been fully explained, the position and pharmacological properties are similar to Gabapentin. The drug attaches to the subunit alpha 2 Delta in the Synapse the channels depending on the voltage is widely distributed in the peripheral nervous system and central nervous system. Has the effect of reducing the calcium line into the nerve end, thereby reducing the release of neurotransmitters such as glutamat, noradrenalin and p.

Pregabalin increases neuromus gaba through increased active glutamic decarboxylase acid, an enzyme that converts neurotransmitters that are easily stimulated as glutamat into GABA inhibitors through a simple step. Like Gabapentin, Pregabalin does not affect GABA A and GABA B receptor, not converted into GABA or to GABA antagonist, and does not change the absorption and divestment of GABA.

Dynamic pharmacokinetics

Pregabalin is quickly absorbed through the gastrointestinal tract when hungry, the peak concentration in plasma is achieved after 1.5 hours during the single and multi -dose. Oral bioactivity is about 90% and dosage depends. In repeated use, stable status achieved in 24 - 48 hours. The absorption reduced when used with food, resulting in CMAX decreased from 20-30% after 2.5 hours, but there is no significant influence on clinical. The drug passes through the bloody barrier easily, through the placenta and breast milk. The drug is not associated with plasma proteins.

Pregabalin is insignificant metabolized, 3% is found intact in the urine and 0.9% is the metabolic N - methylate of Pregabalin. The drug is excreted mainly through the kidneys. Selling time for 6.3 hours. Pregabalin clearance is proportional to creatinine clearance, so the dose should be adjusted for people with renal failure and separation. Pregabalin's pharmacokinetics is linearly within daily dose.

Before taking AusVair 75 medicine for inflammation, peripheral neuralgia (3 blisters x 10 tablets)

How to use

oral medication, use or not with food.

Dosage

Neurological pain

The starting dose is 150 mg/day, divided into 2 drinks. Depending on the response and tolerance of the patient, the dosage may be increased to 300 mg/day after a distance of 3-7 days, and if necessary, it can increase to a maximum of 600 mg/day after another 7 days. The dose exceeds 300 mg/day only for people who are still painful and tolerated with a dose of 300 mg/day, due to the risk of many unwanted effects in high doses.

Treatment of local epilepsy support

The starting dose is 150 mg/day, divided into 2 drinks. Depending on the response and tolerance of the patient, the dosage can be increased to 300 mg/day after 1 week, may increase to up to 600 mg/day after 1 week.

Disseminated anxiety disorders

The starting dose is 150 mg/day. Depending on the response and tolerance of the patient, the dose increased by 300 mg/day after a distance of 1 week, and then may increase to 450 mg/day and then up to 600 maximum/day after weeks.

muscle pain due to fibrosis

The starting dose of 150 mg/day, depending on the response and tolerance of the patient may increase the dose to 300 mg/day after 1 week, can increase the dose of 600 mg/day after 1 week.

Stop taking medicine

If the medication is needed, it is necessary to stop slowly and as directed.

Renal failure

Need to adjust the dose according to creatinine clearance as follows:

Creatinine clearance

Starting dose

Maximum dose of the day

30-60 ml/minute

75 mg

300 mg divided 2-3 times to take

15-29 ml/minute

25-50 mg

150 mg, 1 or 2 times

25 mg

75 mg, 1 time

It is necessary to use an additional dose of 25 - 100 mg/day after each session lasting 4 hours.

People with liver failure

No dose adjustment for people with liver failure.

Children

Safety and effectiveness when taking drugs for children under 12 years old and teenagers aged 12-17 have not been established, so they do not use drugs for these subjects.

Elderly

may need to reduce the dose due to renal function in these people often decreased.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Experience overdose pregabalin is small, the highest pregabalin dose is reported 600 mg. There is no significant consequences for clinical.

Handling

There is no specific antidote. It is possible to indicate vomiting or gastric lavage, maintaining airway if needed. Treatment of symptoms, support, blood decomposition removed about 50% of the drug in 4 hours.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using AusVair 75 you may experience unwanted effects (ADR).

Common, ADR> 1/100

Infections: infection.

Central nervous system: dizziness, sleep, loss, headache.

Eyes: blurred vision, double look.

Cardiovascular: peripheral edema. gastrointestinal tract: weight gain, dry mouth.

Muscle and connective tissue: Run muscles.

Uncommon, 1/1000

Blood and lymphatic system: thrombocytopenia.

The immune system: allergic reactions.

Metabolic and nutrient disorders: fluid fluid, blood glucose.

Central nervous system: neuritis, abnormal thoughts, fatigue, confusion, refreshment, language disorders, attention disorders, loss of coordination, loss/memory loss, pain, dizziness, abnormal sensation/sensory loss, anxiety, depression, loss of orientation, sleep, fever, insults, stunning, stupid state, stupor. eyes: visual disorders, vision loss, eyeball vibration, conjunctivitis. ears: hearing loss. Cardiovascular: chest pain, edema.

Respiratory, chest area, mediastinum: sinusitis, shortness of breath, bronchitis, sore throat - larynx.

Gastrointestinal tract: constipation, appetite, flatulence, flatulence, vomiting, abdominal pain, gastritis.

Skin and subcutaneous tissue: Facial edema, bruises, itching.

Bone and connective tissue disorders: balance disorders, abnormal gait, muscle weakness, joint pain, muscle jerky, back pain, muscle spasms, vibration, abnormalities, increase CPK.

genitals and urinary tracts: urine, urinary incontinence, loss of pleasure, sex reduction.

General: Fake influenza syndrome.

Rare, 1/10000

Infections: abscess.

Blood and lymphatic system: Anemia.

cardiovascular: tachycardia.

Respiratory, chest and mediastinum: apnea.

Gastrointestinal tract: Gastritis.

Skin and subcutaneous tissue: Evaluation. kidney: Acute renal failure.

Genital and urinary tract: Albuminuria. The immune system: Anaphylactic reaction.

Central nervous system: Drug dependence, agitation.

Instructions on how to handle ADR

Some side effects that cause patients to stop taking the drug include:

Dizziness, drowsiness (4%).

Fuzzy vision: 1% must stop the drug. If the visual disorders are prolonged, eye examination (most of themselves go away on their own).

Muscle disease or serum CPK concentration increased 3 times higher.

Weight gain, peripheral edema in people with heart disease before.

Feduna: Although rarely occur, it usually occurs when starting to use the drug, so it is necessary to ask a history of sensitivity and prepare appropriate emergency media.
The risk of suicide: It is necessary for patients and families to know the potential risk of suicide when taking drugs, closely monitoring and paying attention to signal symptoms such as anxiety, struggle, aggression, attack, opposition, stalk, insomnia and depression.
Sudden drugs, must gradually decrease the dose for at least a week.

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

AusVair 75 contraindicated drugs in hypersensitivity fields with pregabalin or any ingredients of the drug.

Be cautious when used

Anti -convulsions, including pregabalin, often increases the risk of suicidal thoughts or behaviors. Therefore, patients need to be closely monitored on depression, the tendency to commit suicide, abnormal behavior changes during the treatment process and need to be instructed to notify the doctor as soon as the above signs appear.

Be cautious when using pregabalin because it can cause peripheral edema, there is no clear combination of peripheral edema and cardiovascular complications (such as hypertension, congestive heart failure) and no kidney failure and liver. When used in combination, pregabalin with thiazolidinedion (anti -diabetes drugs) are at higher risk of increasing body weight and edema than when using alone.

Pregabalin causes increased body weight related to the dose and medication time, however, weight gain is not related to the body mass index (BMI) before treatment, gender or age and not due to edema. Although in short -term research, controlled, weight gain does not combine with important clinical changes in blood pressure, but the long -term effect on the heart has not been clarified. In addition, the drug does not lose blood glucose.

For patients who have had heart disease before, be cautious when taking the drug because it can increase the risk of heart failure.

The medication that affects the central nervous system includes: drowsiness, dizziness, which can reduce both the physical and mental of the patient, so be careful on driving objects or operating machines.

Pregabalin can increase CPK and can cause muscle globin - urinary tract (although rare). Patients need to notify the doctor when pain, muscle weakness, increase pain, especially when accompanied by fever and/or fatigue, discomfort. Must stop the drug when there is a manifestation of muscle disease.

Need to stop slowly and reduce the dose for at least a week before stopping the drug to avoid increasing the frequency of epilepsy as for anticonvulsants in general.

Be careful with patients with a history of drug addiction. Monitoring signs of drug abuse (such as drugs, trend of increasing dose or drug search). In control clinical studies, the proportion of patients taking drugs with refreshing manifestations is 4% compared to 1% of the control group. In studies on patient populations, this rate is greater, from 1 - 12%. When stopping the drug quickly and suddenly, the symptoms of drug dependence such as insomnia, vomiting, headache, diarrhea.

Because this product contains Lactose Monohydrate, it should not be used for patients with some rare genetic problems in tolerance of galactose, lactase deficiency, or poor absorption of glucose - galactose.

The ability to drive and operate machinery

Use a cautious drug for drivers or machinery operating, because the drug can cause side effects of drowsiness, dizziness, visual disorders.

Pregnancy

due to the lack of adequate research and good examination in pregnant women, only medication for pregnant women when the potential for mothers is greater than the potential risk for the fetus.

The period of breastfeeding

It is unknown whether it is excreted through breast milk or not. Should be cautious when used for breastfeeding women.

Interactive drug

Pregabalin increases the concentration/effect of alcohol, anti -diabetes drugs group Thiazolidinon (Glitazon group), central neurological inhibitors, methotrimeprazin, selective Serotonin recovery inhibitors.

The concentration/effect of pregabalin is increased by droperidol, hydroxyzin, methotrimeprazin.

concentration/effect of pregabalin is reduced by ketorolac, ketorolac (small nose), ketorolac (systemic line), mefloquin.

Storage

Store at a temperature not exceeding 30 ° C.

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