Avamys nasal spray 27.5mcg gsk treatment of runny nose, nasal congestion (120 doses of spray)

Dosage form Box x 3300mcg
Specifications Fluticason Furoat
Ingredient Allergic rhinitis

Ingredient

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Composition information	Content
Fluticason Furoat	27.5mcg

Uses

indications

Avamys drugs are indicated in the following cases:

Adults and teenagers (12 years or older):

Treatment of symptoms in the nose (runny nose, nose congestion, itchy nose and sneezing) and symptoms of the eye (itching, the feeling of burning the eyes, watery and redness) of the seasonal allergic rhinitis.

Treatment of nasal symptoms (runny nose, nasal congestion, itchy nose and sneezing) of allergic rhinitis all year round.

Children (2 to 11 years old):

Treatment of nasal symptoms (runny nose, nasal congestion, nasal and sneezing) of both seasonal allergic and allergic rhinitis all year round.

Pharmacokic

Mechanism of action: Fluticason is a fluoride synthetic corticosteroid attached to the steroid frame, has a very high affinity with glucocorticoid receptor and has strong anti -inflammatory effects.

Pharmacokinetics

absorption

Fluticason Furoat has been metabolized quite a lot and is not fully absorbed in the liver and intestines leading to insignificant systemic concentrations. When using 110 micrograms once a day via a nasal spray, the concentration of drugs in plasma is reached below the level of quantitative (less than 10 picograms/ml).

Fluticason Furoat's absolute bioavailability when using 880 micrograms three times daily (total daily dose is 2640 micrograms) is 0.50%.

Distribution

The cohesion with the plasma protein of Fluticason Furoat is greater than 99%. Fluticason Furoat is distributed in an average stable state of 608 l.

Metabolism

Metabolic line is the S-Fluoromethyl Carbothioat functional hydrolysis to form a metabolism of 17 beta-carboxylic acid by cytochrom P450 enzyme CYP3A4.

Elimination

Fluticason Furoat is quickly eliminated (total plasma clearance is 58.7 l/hour) from the whole client week mainly in the form of metabolites without active 17 beta-carboxylic. The excretion mainly through stool after oral medication and venous sugar shows Fluticason Furoat and its metabolites excreted through the bile.

After using the drug by intravenously, the average selling time for the drug is 15.1 hours. About 1% of oral medication and 2% of the drug dose used by vein are excreted in the urine.

Before taking Avamys nasal spray 27.5mcg gsk treatment of runny nose, nasal congestion (120 doses of spray)

How to use

only use Avamys nasal spray through the spray in the nose. It is recommended that patients use the drug regularly to get adequate treatment. The drug acts early about 8 hours after the starting dose. May need drugs for a few days to achieve maximum benefits. It is necessary to explain to the patient that the drug effect does not appear immediately.

Dosage

Adults and teenagers (12 years or older):

The recommended starting dose is 2 sprays (27.5 micrograms/spray) on each side x 1 time/day (total daily dose is 110 micrograms).

Once the symptoms are fully controlled, the reduction of the dose is 1 spray on each side of the nose x 1 time/day (the total daily dose is 55 micrograms) may be effective for maintenance treatment.

Children (2 to 11 years old):

The initial starting dose is 1 spray (27.5 micrograms/spray) on each side x 1 time/day (total daily dose is 55 micrograms).

Can use 2 sprays on each side of the nose x 1 time/day (total daily dose is 110 micrograms) when the patient does not fully respond to a dose of 1 spray on the side of the nose x 1 time/day (the total daily dose is 55 micrograms).

Once the symptoms are fully controlled, the dose should be reduced to 1 spray on each side of the nose x 1 time/day (the total daily dose is 55 micrograms).

Children (under 2 years old):

There is no recommended data for the use of Avamys nasal sprays in the treatment of seasonal allergic rhinitis or allergic rhinitis year -round in children under 2 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Excavity overdose may not need any treatment but follow -up.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Avamys drugs can cause the following unwanted effects (ADR):

Common, ADR> 1/100

Respiratory disorders, chest and mediastinum: nosebleeds, nose ulcers.

Nervous disorders: headache.

Uncommon, 1/1000

Respiratory disorders, chest and mediastinum: nose pain, discomfort in the nose (including a burning sensation, nose irritation and nose aches), dry nose.

Rare, 1/10,000

Respiratory disorders, chest and mediastinum: Perforation of the nasal septum.

The immune system disorder: Hypersensitivity reactions include anaphylactic, angioed, rash and urticaria.

Not determined

Musculoskeletal and connective tissue disorders: underdeveloped.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist with unwanted effects.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

contraindicated use of Avamys spray for patients with hypersensitivity to any component of the drug.

Be cautious when using

There has been a report on systemic effects when using corticosteroid spray through the nose, especially when taking high doses for a long time. These effects are much less occur than taking oral corticosteroids and may vary in patients and differently between corticosteroids.

Observed the deceleration of growth in children with Fluticason Furoat 110 microgram/day for 1 year. Therefore, the lowest dose should be maintained enough to control symptoms for children. Like other corticosteroids used by nasal lines, the doctor should pay attention to the possibility of the systemic effect of steroids including eye changes.

Unwanted effect on the nose: In clinical test data, the most unwanted effects are reported as nosebleeds and nose ulcers. Cases of puncturing the nasal wall when using Fluticason Furoat nasal spray has been reported after the circulation.

Corticosteroids inhaled and in the nose can cause the progression of glaucoma, RX and/or cataracts. Therefore, closely monitoring for patients with vision changes or a history of internal hypertension (IncrASEDED INTRAOCULAR PRESTURE IOP), glaucoma and cataract.

Hypersensitivity reactions, including anaphylaxis, angioedema, itching and urticaria may occur after use.

When using nasal steroids at higher doses than recommended or in sensitive objects when used in accordance with the recommended dose, the systemic effect of corticosteroids as possible Cushing. If these changes occur, slowly stop using Fluticason Furoat nasal spray similar to oral corticosteroid stopping.

The replacement of body corticosteroids with a local corticosteroid may also occur signs of adrenal insufficiency. In addition, some patients may experience corticosteroids, such as joint pain and/or muscle, fatigue, depression. Patients who had previously been treated with long -term corticosteroids switched to corticosteroids on the spot, so they were carefully monitored with acute adrenal failure when responding to stress.

In patients with asthma or diseases that require prolonged treatment with systemic corticosteroids, the reduction of corticosteroid dosage of systemic system can cause a serious play of their symptoms.

The ability to drive and operate machinery

There is no basis to show that the Avamys nasal spray has influenced the ability to drive and operate machinery.

pregnancy and lactation

There is no adequate data on the use of Avamys nasal spray during pregnancy and lactation in humans. Avamys nasal spray should only be used during pregnancy when the benefits of treatment for the mother outstanding potential risks to the fetus.

Lactation period

The excretion of Fluticason Furoat into breast milk has not been studied.

Fluticason Furoat uses unknown nasal sugars whether or not to excrete in breast milk or not. The use of Fluticason Furoat in breastfeeding women should only be considered when the desired benefits for mothers are higher than the potential risk to the baby.

Drug interaction

Fluticason Furoat is quickly eliminated by initial transformation quite a lot through intermediaries Cytochrom P450 3A4.

Based on data on another Glucocorticoid (Fluticason Propionate), metabolized by CYP3A4, not recommended to be used with Ritonavir because of the risk of increased body exposure of Fluticason Furoat.

Be careful when using Fluticason Furoat simultaneously with strong CYP3A4 inhibitors because it is expected to increase the risk of systemic side effects.

Storage

less than 300C, dry place, avoid light.

Do not leave in the refrigerator or freezing.

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