Avodart 0.5mg GSK treatment for benign hyperplasia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Dutasteride
Ingredient Prostate hypertrophy

Ingredient

Composition information	Content
Dutasteride	0.5mg

Uses

indications

Avodart drugs are indicated in the following cases:

Treatment and prevention of the progression of prostate hygiene hyperplasia by reducing symptoms, reducing the size (volume) of the prostate gland, improving urine circulation and reducing the risk of acute urinary retention (AUR - Acute Urinary Retention) as well as reducing the demand for surgery related to BPH.In addition, Avodart is also combined with Tamsulosin as an alpha blocker for treatment and prevention of the progression of prostate hyperplasia (BPH) through reducing prostate size, reducing symptoms, improving urine circulation and reducing the risk of acute urinary retention (AUR) as well as the need for surgery related to BPH.

Pharmacological

dutasteride is a dual inhibitor of 5 alpha -Reductase. Dutasteride inhibits isoenzyme 5 alpha -Reductase for both type 1 and type 2, which are enzymes responsible for converting testosterone into dihydrotestosterone (DHT) in the body. DHT is associated with benign prostatic development (BPH).

The drug is used to treat benign prostatic hyperplasia (BPH) benign in men with prostate prostate. It helps improve urine flow and can also reduce your needs for prostate surgery later.

pharmacokinetics

absorption:

After taking a single dose of 0.5 mg, the peak concentration of dutasteride plasma appears after 1–3 hours of taking the medication. Birth is about 60%. Birth is not affected by food.

Distribution:

dutasteride has a large distribution, highly connected to plasma proteins (> 99.5%).

After taking single doses, the serum concentration reaches 65% of the stable concentration after 1 month and about 90% after 3 months. The drug is widely distributed throughout the body, the drug is also distributed into semen (11.5%).

Metabolism:

The drug is metabolized by CYP3A4 and CYP3A5 into active metabolites, such as monohydroxylate. Not metabolized by CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2C9, CYP2C19, CYP2B6 or CYP2D6.

Era:

dutasteride is widely metabolized. Most are eliminated in the form of metabolism through feces. Only a very small amount of unchanged (less than 0.1% of the dose) is found in the urine. The sale time of the drug is about 3–5 weeks.

Before taking Avodart 0.5mg GSK treatment for benign hyperplasia (3 blisters x 10 tablets)

How to use

oral Avodart drugs. When drinking, swallowing the capsule, not chewing or opening the follicles because the ingredients in the follicles can irritate the oral mucosa. Drugs can be taken during or outside meals.

Dosage

Adults (including the elderly)

Should swallow the whole capsule, should not chew or open the cyst because it is exposed to the follicle that can cause the oral mucosa to irritate the oral mucosa. Avodart can be taken during or outside the meal, the proposal of Avodart is a capsule (0.5 mg) oral once daily.

It is possible to see the response early but may need treatment for at least 6 months to be able to assess whether or not to meet the desired network treatment.

To treat benign hypertension, Avodart can be used for monomers or in combination with Alpha Tamsulosin (0.4 mg).

kidney failure

No research on kidney failure on dynamic pharmacokinetics of dutasteride. However, there is no need to adjust the dutasteride dose in patients with renal failure.

liver failure

Not studying the effects of liver failure on dynamic dynamics of dutasteride.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In clinical studies, when the patient is used by 5 mg daily for 6 months, there is no more unwanted effect other than the unwanted effects that have been encountered at 0.5 mg treatment.

Because there is no specific antidote for dutasteride, in case of an overdose suspected, it is advisable to conduct a million treatment and use appropriate support measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Avodart, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Rare, 1/10000

Skin and subcutaneous disorders: hair loss (mainly hair loss), hairy hair.

Very rare, ADR

Mental disorders: depression.

Immune system disorders: allergic reactions, including rash, itching, urticaria, localized edema and angioedema.

Disorders on reproductive and breast: testicular pain and testicular swelling.

Instructions for handling ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

AVODART drug is contraindicated in the following cases:

Hypersensitivity to dutasteride, other 5-alpha-Reductase inhibitors or any ingredients of the drug.

Women and children.

Be cautious when using

Prostate cancer: Men use Avodart should be evaluated regularly about the risk of prostate cancer including PSA test.

Prostate specific antigen (PSA): is an important component in the screening process to detect prostate cancer. The drug causes an average reduction of PSA by about 50% after 6 months of treatment, so compared to PSA level before treatment.

Cardiovascular adverse events.

Breast cancer: The patient promptly reports any changes in the mammary gland such as tumor or nipple secretion.

Leaked capsules: If contact with capsules leaked, wash the skin immediately with soap and water.

Hepatic failure: Because the drug is widely metabolized and has a half -life of 3 to 5 weeks, should be cautious when using Avodart for patients with liver disease.

The ability to drive and operate machinery

Dutasteride treatment does not affect the ability to drive and operate machinery.

Pregnancy

Contraindicated dutasteride for women. Dutasteride research is not conducted in women clinical data suggesting that inhibiting dihydrotestosterone amounts may inhibit the development of an external genital organs in her son's embryo when the mother uses Dutasteride.

The period of breastfeeding

It is unknown whether dutasteride will excrete in breast milk or not. Need to carefully consider the benefits and risks for mothers and babies. Do not arbitrarily use the drug without reading the instructions and instructions of the doctor to protect the mother and the baby.

Drug interaction

dutasteride is metabolized by isenzyme CYP3A4. Therefore, the concentration of dutasteride in the blood may increase when the presence of CYP3A4 inhibitors such as verapamil, diltiazem.

Do not observe clinical significant adverse interactions when using dutasteride simultaneously and other drugs such as blood lipid drugs, enzyme inhibitors, beta-year blockers, Calcium channel blockers, corticoids, diuretic, non-non-steroid anti-inflammatory, antibiotics ...

Storage

Store in a dry place, the temperature does not exceed 30ºC.

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