Axofen Aristopharma oral phlegm for allergic rhinitis, urticaria (50ml)

Dosage form 1 bottle box
Specifications Fexofenadin hydrochlorid
Ingredient Allergic rhinitis, itching, sneezing, hives, stuffy nose

Ingredient

Composition information	Content
Fexofenadin hydrochlorid	6mg/ml

Uses

indications

Axofen drug indicated in the following cases:

Seasonal allergic rhinitis: Fexofenadin is indicated to reduce the symptoms of seasonal allergic rhinitis for adults and children ≥ 6 years old. Symptoms such as sneezing, runny nose, itchy eyes, nose and throat, red eyes and watery. Significantly reduces itching and urticaria. Fexofenadin is a pharmacological metabolic substance of terfenadin.

Human -hute -throwned hildo -throwning studies, using Fexofenadin hydrochlorid once and twice a day shows that the drug shows antihistamine effect within 1 hour, reaching the maximum level after 6 hours and lasting effect for 24 hours. There is no evidence of tolerance to these effects after 28 days of medication. Clinical studies in seasonal allergic rhinitis shows that the 120 mg dose is sufficient within 24 hours.

There is no significant difference in the QT segment in seasonal patients with seasonal allergic rhinitis using fexofenadin hydrochlorid at the dose up to 240 mg x 2 times/day x 2 weeks compared to placebo. Also, there is no significant change in the QT segment in healthy people using fexofenadin hydrochlorid at the dose of 60 mg x 2 times/day x 6 months, 400mg x 2 times/day x 6.5 days, 240 mg/day/day x 1 year compared to placebo.

Fexofenadin Hydrochlorid (5-10mg/kg oral inhibiting bronchospasm caused by antigen in the mouse and inhibiting the release of histamine from the village nursing concentration on the concentration of treatment (10-100μm).

Dynamic pharmacokinetics

Fexofenadin hydrochlorid is quickly absorbed into the body by oral, with a maximum concentration time about 1-3 hours after drinking. The average concentration is about 427 ng/ml after taking 120 mg/day/day and about 494 ng/ml after taking the dose of 180 mg/time/day.

Fexofenadin binds to plasma proteins about 60-70%. Fexofenadin is negligible (through the liver or without liver), because Fexofenadin is the main compound found in urine and feces of animals and humans. Fexofenadin plasma plasma concentrations decrease in a exponential jaw, with the final selling time of about 11-15 hours after drinking many doses.The pharmacokinetics of Fexofenadin are linear when taking a dose and many doses of up to 120 mg 2 times/day. The dose of 240 mg x twice a day increases slightly (about 8.8%) under the concentration curve in a stable state, indicating that the actual pharmacokinetics of Fexofenadin is linear at the dose of 40 - 240 mg /day. The main excretion line is through the secretion of bile, about 10% of the dose is excreted through urine in the form of unchanged.

Before taking Axofen Aristopharma oral phlegm for allergic rhinitis, urticaria (50ml)

How to use

Axofen drugs in the form of oral fluid.

Dosage

Dosage to support the treatment of seasonal allergic rhinitis and chronic or spontaneous urticaria:

adults, children> 12 years old: take a dose of 60mg x 2 times daily or 180mg x 2 times daily.

Adults: take the dose of 60 mg x 2 times daily. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The side effects of fexofenadin are almost the effects of the placebo.

Side reactions are often noticed such as headache, indigestion, fatigue, drowsiness, nausea, angina, shortness of breath ...

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

anti -contraindications in the following cases:

Contraindicated for patients with hypersensitivity to Fexofenadin or any excipients of the drug.

Be cautious when using

like most new drugs, only very few data about the elderly, patients with liver failure or kidney failure.

Should use Fexofenadin Hydrochlorid carefully in these special patients.

Safety and effectiveness of fexofenadin on children under 6 years old has not been studied.

Medicinal interaction

Simultaneous use of fexofenadin hydrochlorid with ketoconazole or erythromycin may increase the content of fexofendin in plasma.

Antacomicated drugs containing aluminum or magnesium can reduce the absorption of fexofenadin. Grapefruit, oranges and apple juice can reduce the bioavailability of fexofenadin.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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