Azicine 250mg Stella medicine for infections (1 blister x 6 tablets)

Dosage form Box of 1 blister x 6 tablets
Specifications Azithromycine
Ingredient Tonsillitis, sore throat, sinusitis, cervicitis, pneumonia

Ingredient

Composition information	Content
Azithromycine	250mg

Uses

Indications

Azicine 250mg drug is indicated in the following cases:

Treatment of bacterial infections caused by sensitive bacteria, lower respiratory infections including bronchitis and pneumonia, in dental infections, in skin and soft tissue infections, in acute otitis media and in the upper respiratory tract infection, including sinusitis, pharyngitis/tonsillitis.

Treatment of non -complication of genital infections caused by Chlamydia trachomatis, chancroid disease (chancroid) caused by Haemophilus ducreyi, and non -complicated genital infections caused by Neisseria Gonorrhoeae without multi -resistant indicated not only to treat bacterial infections simultaneously with Treponema Pallidum.

Can be used alone azithromycin or together with rifabutin to prevent Mycobacterium avium-intracellulare complex (Mac), which is a common chance infection in patients with human immunodeficiency virus infections (Him phase progression).

Indications for combination of azithromycin with ethambutol to treat spreading Mac infection (DMAC) in patients with HIV -contaminated stage.

Pharmacokological

azithromycin is the first drug of macrolid antibiotic groups, known as Azalids, and chemically different from erythromycin. Chemically it is formed by attaching an nitrogen atom to the lactone ring of erythromycin A. Azithromycin attached to the 23S trna of the ribosom 50s subunit. It prevents protein synthesis by inhibiting the peptide/displacement of protein synthesis and inhibiting the cohesion of Ribosom 50s.

Bacteria often sensitive to azithromycin include anaerobic gram -positive and aerobic bacteria (inductance strains with erythromycin): S. Aureus, Streptococcus Agalactiae S. Pneumoniae, Streptococcus Pyogenes, Streptococci Demonstrate Bleeding B (Group C, E G) Streptococci. Macrolid -resistant strains are relatively common in anaerobic gram -positive bacteria and aerobic bacteria, especially S. Aureus, Methicillin resistant (MRSA) and S. Pneumoniae resistant penicillin (PRSP). The anaerobic and aerobic grams: Bordetella Pertussis, Campylobacter Jejuni, Haemophilus Ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae, Legionella Pneumophila, Moraxella Catarrhalis, and Neenseria Gonorrhoeea. Pseudomonas and most enterobacteriaceae are inherently resistant to azithromycin, although azithromycin has been used to treat Salmonella Enterica infection. Anaerobic bacteria: Clostridium perfringens, peptostreptococcus spp. and Prevotella Bivia.

Other bacteria: Borrelia Burgdorferi, Chlamydia Trachomatis, Chlamydophila Pneumoniae, Mycoplasma Pneumoniae, Treponema Pallidum, and Ureaplasma ureaticum. The chance of being infected with HIV infection: Mac+, and the standard microorganisms Pneumocystis Jirovecii and Toxoplasma Gondii.

pharmacokinetic

absorption

After drinking on a drink, azithromycin is widely distributed throughout the body; Birth is approximately 37%. The drug achieved the peak concentration in plasma after 2-3 hours.

Distribution

In animal models, this condition leads to high concentrations of azithromycin, which is taken to the infection position. Human pharmacokinetics studies have shown that azithromycin's concentration is significantly higher than in plasma (up to 50 times the maximum concentration observed in plasma), which shows that the drug has high cohesion to the tissue. The concentration of drugs in target tissues such as lungs, tonsils and prostate is exceeding the mic90 for most pathogens after using a single dose of 500 mg.

Metabolism

There is no study in vitro and in vivo evaluating azithromycin metabolism.

Elimination

Semi -selling time in plasma is closely related to the semi -exhaust time in tissue, about 2-4 days. About 12% of the dose after intravenous injection is excreted by the urinary tract in the form of non -metabolic within 3 days, most of the first 24 hours. The excretion of bile is the main excretion of azithromycin for unproperable drugs after oral use.

Before taking Azicine 250mg Stella medicine for infections (1 blister x 6 tablets)

How to use

Take a single dose of the day. You can drink azithromycin capsules with or not with food.

Dosage

Adults:

To treat sexually transmitted diseases caused by Chlamydia Trachomatis, Haemophilus Ducrey, only 1000 mg.

With sensitive Neisseria Gonorrhoeae, the recommended dose is 1000 mg or 2000 mg Azithromycin simultaneously used for 250 or 500 mg Ceftriaxon according to clinical treatment instructions.

To prevent Mac infection in patients with viral infections causing immunodeficiency in humans (HIM), taking a dose of 1200 mg once a week. To treat DMAC infections in HIV -infected patients, the dose of 600 mg should be used once a day.

With other indications that can be taken by oral, the total dose is 1500 mg, divided into 3 days, 500 mg daily. Can be replaced by such a total dose but used for 5 days, 500 mg of day 1, then 250 mg/day from 2 to 5.

Children:

The maximum dosage recommended for any treatment in children is 1500 mg. Weight> 45 kg: 3 -day treatment: Dosage as adults, 5 -day treatment for dosage like adults.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In the case of overdose, symptomatic treatment and general support are specified as required.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Azicine 250mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Gastrointestinal disorders: nausea, vomiting, diarrhea, loose stool, uncomfortable abdomen (pain/spasm), and flatulence.

Infections and parasites: Candida and vaginitis.

Blood system and lymphatic system: Mild neutropenia.

Disorders at and internal ears: hearing loss (including reduction of hearing, deafness and/tinnitus). Rarely reports on serious skin reactions including diverse roses, acute all-body pustules (AGEP), Stevens-Johnson syndrome (SMS), and poisoned epidermal necrosis (name) and drug reactions that cause eosinophilia and eosine and systemic symptoms (Dress). Acute kidney.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Azicine 250M drug is contraindicated in the following cases: hypersensitivity to azithromycin, erythromycin, with any antibiotic of the MacRolid family or ketolid, or any excipient.

Precautions when using

Hypersensitivity: As with Erythromycin and other macrolids, there have been reports on rare serious allergic reactions, including veins and anaphylactic shock (rarely death), and skin reactions including acne-bodied pustules (AGEP), StevenS-Johnson (SJS), and neutral syndrome Toxicity (ten) (rarely death) and drug reaction causes eosinophilia to love eosin and millions of body (dress). A few reactions with this azithromycin have caused recurrent symptoms and need to be monitored and treated longer. If allergic reactions, immediately stop the drug and use appropriate treatment.

Liver poisoning: Because the liver is the main excretion of azithromycin, the use of azithromycin needs to be cautious in patients with severe liver disease. There have been reports on abnormal liver function, hepatitis, jaundice due to biliary obstruction, liver necrosis and liver failure, some of these cases have led to death. When there are signs and symptoms of hepatitis, azithromycin must be stopped immediately.

Enlargement pyloric pylorus in young children: In the process of monitoring the use of azithromycin on newborn babies (taking drugs up to 42 days of age), there is a report on the case of hypertrophic pyloric stenosis in young children.

Sino: Like any antibiotic preparation, it is necessary to observe the signs of superinfection of non -sensitive microorganisms, including mushrooms.

diarrhea caused by Clostridium Difficile: diarrhea caused by Clostridium difficile (Clostridium Difficile Associated Diarrhea - CDAD) has been reported when using most antibacterial agents, including azithromycin, and severity of mild diarrhea to mild diarrhea.

Renal failure: In patients with severe renal impairment (ger

extends the QT interval: The condition of the heart muscle is found and the QT range has been seen, causing risk of arrhythmia and torsion when using macrolids, including azithromycin.

Myastheniastick: There has been a report on the academic phase of symptoms of myasthenia gravis in patients treated with azithromycin.

The ability to drive and operate machinery

There is no evidence that azithromycin has an influence on the patient's ability to drive and operate machinery. However, unwanted effects such as dizziness, convulsions, dizziness, drowsiness and fainting have been reported when using azithromycin can affect the ability to drive and operate machinery

Pregnancy

Animal reproductive studies have been conducted at close doses with mild toxicity concentrations with reproductiveity. In these studies, there is no evidence of harmful to the embryo of azithromycin. However, there is no adequate and controlled research on pregnant women, only azithromycin should only be used during pregnancy if really necessary.

Breastfeeding period

azithromycin is reported as excreted by breast milk, but there is no adequate clinical research and well controlled in breastfeeding women about the pharmacokinetic properties of azithromycin secretion through breast milk. Be careful when breastfeeding women use azithromycin.

Medicinal interaction

digoxin: simultaneously use antibiotics of the macrolid family including azithromycin with the substrate of p-glycoprotein, like digoxin, which is reported to increase the substrate concentration of p-glycoprotein in serum.

Nelfinavir: simultaneously use azithromycin (1200 mg) and Nelfinavir in a stable state (750 mg, 3 times daily), leading to an increase in azithromycin level.

Rifabutin: simultaneously use azithromycin and rifabutin does not affect the plasma concentrations of both drugs. Observed neutropenia in those treated simultaneously with azithromycin and rifabutin.

Sildenafil: In volunteers who are normal healthy men, there is no evidence of the influence of azithromycin (500 mg, daily for 3 days) to AUC and C of Sildenafil or its main metabolites during the circulation.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

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