Baburol Agimexpharm Treatment Treatment of bronchial asthma, bronchitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bambuterol
Ingredient Agimex

Ingredient

Composition information	Content
Bambuterol	10mg

Uses

indications

Baburol drugs are indicated in the following cases:

Treatment of bronchial asthma, chronic bronchitis, piercing gas and other lung diseases with bronchial spasms.

Pharmacokology

Baburol contains bambuterol is the precursor of terbutaline, the owner of the venom on the beta receptor, selective stimulation on beta-2, thus relaxing bronchial muscles, inhibiting endogenous spasms, inhibiting edematous reactions caused by endogenous intermediate substances and increasing the clearance of the hair system.

pharmacokinetics

absorption:

About 20% of the dose of Bambuterol oral oral absorption. The absorption of drugs is not affected when used simultaneously with food. The maximum concentration in the plasma of terbutalin, the metabolites are active, achieved within 2-6 hours. The effect time lasts at least 24 hours. Achieving stable concentration after 4-5 days of treatment.

Metabolism:

After absorption, bambuterol is slowly metabolized by hydrolysis reaction (by enamel cholinesterase in plasma) and oxidation into terbutaline is active. About 1/3 of the absorption bambuterol dose is metabolized in the intestinal wall and liver, mainly into intermediate metabolic forms.

In adults, about 10% bambuterol taken into transforming into terbutaline.

Children have a smaller terbutaline clearance, but terbutaline is also less than adults. Therefore, children of 6–12 years old should be indicated for adults, younger children (2–5 years) often take lower doses.

Era:

Bambuterol's half -life after drinking about 13 hours. The half -life of metabolites has a terbutaline activity about 21 hours. Bambuterol and its metabolic forms including terbutaline are excreted mainly through the kidneys.

Before taking Baburol Agimexpharm Treatment Treatment of bronchial asthma, bronchitis (3 blisters x 10 tablets)

How to use

oral medication. Should take medicine right before going to bed.

Dosage

Dosage 1 time/day. Need to adjust the appropriate dose.

Adults: The indicated dose of 10 mg starts. The dose can be increased by 20 mg after 1–2 weeks, depending on the clinical effect. In patients who have previously tolerated the oral beta-2 owner, the starting dose is 20 mg.

Children 2–5 years old: The usual recommendation is 5 mg/time/day.

Children 6–12 years old: recommended starting dose is 10mg/time/day.

Elderly: Used by adult dose.

In patients with renal function (GFR ≤ 50 ml/min), the starting dose is 5 mg; May be up to 10 mg after 1–2 weeks, depending on the clinical effect.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

In case of severe overdose, the following methods should be taken: gastric lavage, activated carbon. Assess the balance of acidic alkaline, blood sugar and electrolytes. Monitor the frequency, heart rate and blood pressure.

The appropriate detoxification substance when overdose bambuterol is a selective beta receptor inhibitor, but the beta receptor inhibitors should be used cautiously in patients with a history of bronchospasm.

If the peripheral resistance is reduced through the intermediary Beta-2, significantly contributes to a decrease in blood pressure, it is necessary to compensate for plasma volume.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Baburol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Muscle muscle: Run muscles, cramps.

nerve: headache, sleep disorders and behavioral disorders such as anxiety, hyperactive, restlessness. Cardiovascular: Brushing the chest.

Uncommon, 1/1000

Cardiovascular: tachycardia, atrial fibrillation, ventricular tachycardia, extra systolic.

Rare, 1/10000

Skin: urticaria, skin rash.

digestive: nausea. cardiovascular: local myocardial ischemia.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Baburol drugs contraindicated in the following case:

Hypersensitivity to terbutaline or any ingredients of the drug.

Be cautious when used

Because terbutaline is excreted mainly through the kidney, need to reduce half the dose in patients with kidney function damage (GFR ≤ 50ml/min).

In cirrhosis patients and patients with severe liver function damage due to other causes, daily doses must be adjusted appropriately for each individual, need to assess the ability to convert bambuterol into terbutaline in patients with impaired or not. Therefore, based on the viewpoint of practice, direct use of terbutaline activity is more suitable in these patients.

Need to use caution in patients with armor poisoning.

Cardiovascular effects can be seen with sympathetic drugs, including bambuterol. There are some evidence of the rare occurrence of myocardial ischemia related to beta agonized substances. Patients with severe heart disease (for example, myocardial ischemia, arrhythmia or severe heart failure) are taking bambuterol, so they are warned to find medical advice if the patient feels chest pain or other symptoms of heart disease are worse. Pay attention to assessments of symptoms such as shortness of breath and chest pain, because it may be a symptom of respiratory or cardiovascular origin.

Due to the effect of increasing blood sugar of beta-2 agar, it is necessary to better control blood sugar in patients with diabetes at the beginning of treatment.

Due to the positive muscle contraction of Beta-2, these drugs should not be used for patients with hypertrophic cardiomyopathy.

Hyperbathing hypokalemia may occur when treated with beta-2 agar. It is necessary to be especially careful in acute severe severe asthma attacks due to increased risk of hypokalemia when reducing blood oxygen. The impact of reducing potassium can occur during coordination treatment. Need to monitor serum potassium concentration in these cases.

Be careful when using bambuterol treatment for patients who are likely to suffer from an angular glaucoma.

Baburol contains lactose. Patients with rare genetic problems are galactose intolerance, lactase deficiency or glucose -galactose abutment should not be taken.

The ability to drive and operate machinery

has not recorded the drug that affects the driver and operates machinery. However, it should be noted that the drug can cause muscle tremor, headache, cramping, sleep disorders.

Pregnancy

although it has not been seen to cause teratogenic effects in animals after using bambuterol, need to be cautious in the first 3 months of pregnancy.

Air hypoglycemia is recorded in premature babies whose mothers are treated with Beta-2.

Breastfeeding period

Unknown bambuterol or intermediate metabolic forms through breast milk or not. Terbutaline passes through breast milk but does not see the impact on the emulsion at the treatment dose.

Drug interaction

bambuterol prolongs the muscle stretch effect of Suxamethonium (Succinylcholine). This impact is due to plasma cholinesterase, which is the inactivated Suxamethonium, partially inhibited by Bambuterol. The inhibition depends on the dosage and can recover completely after stopping treatment with Bambuterol. This interaction should also be considered with other muscle relaxants metabolized by CholininineseTerase.

Beta receptor inhibitors (including eye drops), especially non -selective inhibitors, can inhibit partial or complete effects of beta receptor stimulants.

Hypotension may occur when treated with beta-2 agonists and worsen when treated simultaneously with the derivatives of xanthin, steroids and diuretics.

Storage

temperature below 30ºC, avoid moisture and light.

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