Babytrim - New Pharbaco powder for infection treatment (10 packs x 1.5g)

Chronic or recurrent urinary tract infections: Children 2 months and older: The usual dose of cotrimoxazol is 8 mg trimethoprim (in combination of cotrimoxazol)/kg/day divided into 2 times apart 12 hours, for 10-14 days.

Experience of chronic bronchitis

Children 2 months and older: The usual dose of cotrimoxazol is 8 mg trimethoprim (in combination of cotrimoxazol)/kg/day divided into 2 times 12 hours apart. The normal treatment time is 10 days.

Gastrointestinal tract infections

Bacillary dysentery (S.Flexneri or S. Sonnei): Children: 8 mg trimethoprim (in combination of cotrimoxazol)/kg/day divided into 2 times 12 hours apart, for 5 days.

Brucella disease

Children dose 10 mg/kg/day trimethoprim (in combination of cotrimoxazol) divided into 2 times, for 4-6 weeks.

Cholera

Children dose 4 - 5 mg trimethoprim (in combination of cotrimoxazol)/kg/day divided into 2 times 12 hours apart, drink for 3 days. Coordinate with infusion and electrolytes.

Plague

Preventive for people who come into contact with people with pulmonary plague. Children at least 2 months and older: The dose of 8 mg trimethoprim (in combination of cotrimoxazol)/kg/day divided into 2 times equal, drink 12 hours apart, for 7 days.

pneumocystis carinii pneumonia (Pneumocystis Jiroveci)

Children take 15 - 20 mg trimethoprim (in combination of cotrimoxazol)/kg/day divided into 3 or 4 small doses equal. The usual treatment time is 14 - 21 days.

Priority or secondary backup

Backup in children, including HIV -infected children: Trimethoprim dosage disruption regimen (in combination of cotrimoxazol) is 150 mg/day divided into 2 small doses, drink for 3 days a week.

Toxoplasma disease

Backup in children with HIV infected: Trimethoprim dose (in combination of cotrimoxazol) is 150 mg/m2/day divided into 2 small doses.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Anorexia, nausea, vomiting, headache, unconscious. Hematopoietic disorders and jaundice are late manifestations of overdose, inhibitors.

Handling

Causes vomiting, gastric lavage. Acidification of urine to increase trimethoprim elimination. If there are signs of marrow inhibition, patients need to use leucovorin (folinic acid) 5 - 15 mg/day until hematoma recovery. Hematalo fertilizer only removes a small amount of medicine. The abdominal division is ineffective.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Severe renal failure without monitoring the concentration of drugs in plasma.

Be cautious when using

death, although very rarely occurred due to severe reactions including: liver necrosis, leukopenia, hyperplasmic anemia, hematuria disorders and hypersensitivity of the respiratory tract. The life -threatening skin reaction of Stevens - Johnson (SJS) syndrome and poisoned epidermal necrosis (Ten) has been reported with the use of cotrimoxazols.

Patients must be notified of signs and symptoms and closely monitor skin reactions. The highest risk appears SJS and Ten are in the first weeks of treatment. If the symptoms or signs of SJS or ten (for example, the skin rash progresses regularly with blisters or mucosal lesions), it should be discontinued with cotrimoxazol.

The best result in controlling SJS and Ten is early diagnosis and immediately stop any suspected drug. The early stop will give better prognosis. If the patient has been sjs or ten when using cotrimoxazol, do not re -use cotrimoxazol for this patient at any time.

Special care is always encouraged when treating older patients because they are more sensitive to harmful reactions and are susceptible to serious effects, as a special result when there exists complicated conditions, such as renal failure and/or impaired liver function and/or simultaneous use of other drugs.

regularly check the monthly blood count in patients with cotrimoxazol for a long time, or patients with folat or elderly; Because there is the possibility of changing without symptoms of hematology due to lack of folat. These changes can be overcome when using folic acid (5 - 10 mg/day) without affecting the antibacterial activity of the drug.

The drug can cause hemolytic anemia in people with G6DP deficiency. Precautions when taking drugs for patients with serious allergies or bronchial asthma. Cotrimoxazol should not be used in the treatment of sore throat due to streptococcal beta soluble group A; Because the treatment of pharyngeal infections is less effective than penicillin.

Trimethoprim has been recorded reducing phenylalanin metabolism but does not make sense in patients with diet phenylketon with strict diet. Cotrimoxazol should not be indicated for patients to know or doubt Porphyrin metabolism disorders. Both trimethoprim and sulfonamid (although it is not specifically sulfamethoxazol), is more serious than this disorder.

Strict monitoring of blood potassium in patients at risk of hyperkalemia. Except for careful supervision, cotrimoxazole should not be used for patients with serious hematological disorders. Cotrimoxazol is used for patients treated toxic toxicity with little or no effect on the bone marrow or peripheral blood. The combination of antibiotics in cotrimoxazol should only be used when, according to doctors, the benefits of treatment are greater than any possible risks; It is necessary to consider the use of the most effective antibacterial.

The ability to drive and operate machinery

There is still no studies to investigate the effects of cotrimoxazol on driving or operating machinery. Moreover, the adverse effects on these activities cannot be predicted from the effects of the drug. However, it should be noted for the clinical condition of the patient and the unwanted effects of cotrimoxazol when used for patients with the ability to drive and operate machinery.

Pregnancy

Sulfonamid can cause jaundice in children during the period of birth due to pushing bilirubin from albumin. Because trimethoprim and sulfamethoxazol can hinder folic acid metabolism, the drug is only used during pregnancy when necessary. If you need to take the drug during pregnancy, it is important to use folic acid.

The period of breastfeeding

The drug excreted through breast milk, so women during breastfeeding are not allowed to take the drug. Babies are very sensitive to the toxic effect of the drug.

Drug interaction

trimethoprim may affect plasma/serum creatinine when using Picrat alkaline reaction to evaluate. This can lead to increased plasma/serum creatinine levels to 10%. Creatinine clearance is decreased: The excretion in the renal tubules of creatinine decreased from 23% to 9% while glomerular filtration remains unchanged.

In some cases, simultaneous treatment of cotrimoxazol with zidovudine may increase the risk of side hematology. If treated at the same time is necessary, it is necessary to consider to monitor hematology parameters.

The recovery impairment has been observed in patients treated with cotrimoxazol and cyclosporin after kidney transplantation.

Simultaneous use of rifampicin and cotrimoxazols shorten trimethoprim's disposal time after about a week. This is not considered clinical significance. When using Trimethoprim simultaneously with cation drugs in the physiological pH and partially eliminated through the kidneys (for example, Procainamid, Amantadin), the competitive inhibitor will lead to an increase in plasma concentration of one or both drugs.

In older patients who use simultaneously with diuretics, mainly thiazid, which may increase the risk of thrombocytopenia with or without hemorrhage. There are reports showing patients using pyrimethamine at the dose exceeding 25 mg per week can worsen huge red blood cell anemia if used simultaneously with cotrimoxazol.

cotrimoxazol has been shown to increase Warfarin's anticoagulant activities through the selective inhibition of stereopetic selection of its transformation. Sulfamethoxazol can replace warfarin sites with plasma albumin protein in vitro. It is necessary to strictly control anticoagulants while using cotrimoxazol.

cotrimoxazole extends phenytoin's disposal time and if combined treatment can lead to excessive phenytoin effect. It is necessary to closely monitor the condition of the patient and the level of phenytoin in serum.

Simultaneous use of trimethoprim with digoxin increases the concentration of digoxin in plasma in some elderly patients.

cotrimoxazol may increase the free concentration of methotrexate in plasma. Trimethoprim affects methotrexate quantitative tests in serum when using Dihydrofolate Reductase from lactobacillus casei in tests. There is no effect if methotrexate is quantified by radioactive immunity.

Use trimethoprim/sulfamethoxazol 160 mg/800 mg (cotrimoxazol) increases 40% lamivudine concentration (due to trimethoprim). Lamivudin does not affect the pharmacokinetics of trimethoprim or sulfamethoxazol.

Interaction with sulfonylurea hypoglycemic drugs is not common but this ability has been reported. Be careful in patients who are taking drugs that cause hyperkalemia. If cotrimoxazol is considered an appropriate therapy in patients who are taking other folat drugs such as methotrexate, adding folat.