Bactamox 1g Imexpharm medicine for infection (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, sulbactam
Ingredient Tonsillitis, otitis media, sinusitis, urinary tract infections, skin infections and soft tissue, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition information	Content
Amoxicillin	875mg
Sulbactam	125mg

Uses

Indications

Amoxicillin drugs are indicated in the following cases:

Treatment of infections caused by sensitive bacteria, including:

Ear tinema infection: tonsillitis, sinusitis, otitis media. Lower respiratory infections: acute and chronic bronchitis, bronchiomic pneumonia. Urinary tract infections: cystitis, urethritis, pyelonephritis female genital tract infections.

Skin infections and soft tissue: pimples, abscesses, wound infections.

Bone and joint infections.

Dental infections: tooth abscess.

Other infections: infections caused by abortion, obstetric blood infections, abdominal infections.

This drug is only used by a doctor.

Pharmacokological

Amoxicillin is a semi-synthetic antibiotic belonging to the Beta-Lactam group with wide bactericidal spectrum for many gram-positive and gram-negative bacteria due to synthetic inhibition of bacterial cells. Amoxicillin is easily destroyed by beta-lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenzae).

Sulbactam is an unfavorable competitive inhibitor with beta-lactamase. The presence of sulbactam in the composition increases the effects and expansion of the amoxicillin antibacterial spectrum with beta-lactamase seminarians.

antibacterial spectrum:

Gram -positive bacteria: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Staphylococcus Epidemidis, Staphylococcus Sprophyticus.

Gram -negative bacteria: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella species, Enterobacter, Neisseria Gonorrhoeae, Moraxella CatinhLrhalis, acinetobacter.

Anaerobic bacteria: Baceroides including B. Fragilis, Clostridium, Peptococcus.

pharmacokinetics

Amoxicillin is well absorbed after drinking and durable with stomach acid. Food does not affect the absorption of drugs. The average peak concentration in serum is achieved after 1-2 hours after drinking.

Amoxicillin is quickly distributed into most tissues and fluids in the body eliminating brain tissue and cerebrospinal fluid, but when the meninges are inflamed, the amoxicillin diffuses easily. About 20% of the drug is connected to serum protein. The half -life of amoxicillin is about 1 hour, longer in infants and the elderly. In people with kidney failure, the half -life of the drug is about 7-20 hours. About 60% of the oral dosage of amoxicillin eliminates raw form into the urine within 6 - 8 hours. Amoxicillin passes the placenta and is excreted in breast milk in small amounts.

Sulbactam is well absorbed after drinking. The drug diffuses well into the tissue and body fluid. The peak concentration of Sulbactam's serum also achieved the same time as amoxicillin. About 40% of sulbactam associated with plasma proteins. Sulbactam is excreted mainly urine in the form of unchanged (75 - 85%). The half -life of sulbactam cancellation is about 1 hour and lasts longer in people with severe renal failure. The drug is given the placenta and is excreted in breast milk.

Before taking Bactamox 1g Imexpharm medicine for infection (2 blisters x 7 tablets)

How to use

Bactamox medicine is recommended to take medicine before or after meals.

Dosage

Amoxicillin dosage for adults and children over 12 years old?

Used in severe infections.

Adults and children over 12 years: Usually 1 capsule 2 times/day.

Amoxicillin dose for children under 12 years old?

Amoxicillin drugs are not for children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Using more drugs will not improve your symptoms, instead they can cause poisoning or serious side effects. If you suspect that you or anyone else may have overdose amoxicillin, please go to the emergency room at the nearest hospital or hospital. Carry a box, shell, or a pharmacy with you to help doctors have the necessary information.

The drug is less likely to cause complications, because it is well tolerated even at high doses. The acute reactions occur depending on the hypersensitivity of each individual. In case of overdose, stop taking the drug immediately and use supportive measures, can cause vomiting, gastric lavage if newly overdosed. There is no specific antidote. Amoxicillin and sulbactam can be removed by hemolysis.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Bactamox, you may experience unwanted effects (ADR). Some of the side effects recorded in research on users of this drug are:

Common side effects: diarrhea , itching, foreign rash.

Uncommon side effects: nausea, vomiting, eosinophilia, rash, hepatitis and jaundice, Transaminase increasing.

Rare side effects: anaphylactic reactions, scales, platelets, leukopenia, hemolytic anemia, fake colitis, Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning, interstitial nephritis.

This is not a full portfolio of all side effects and may occur other side effects. If you encounter any unwanted effect, stop taking the medication and immediately notify your doctor or immediately go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bactamox drugs contraindicated in the following cases:

Hypersensitivity to drug components or antibiotics group penicillin, cephalosporin. History of gastrointestinal diseases, especially ulcerative colitis, Crohn disease or colitis due to antibiotics.

History of jaundice or liver dysfunction.

Patients with renal failure with Creatinin CrCl clearance

Children under 12 years old.

Be cautious when taking drugs

Signs and symptoms of cholestasis jaundice are less occurring when taking the drug but may be severe. However, those symptoms often recover and will end after 6 weeks of stopping treatment. Severe hypersensitivity reactions and sometimes lead to death (anaphylactic form) have been reported in patients using penicillin antibiotics.

There has been an erythema (diverse) rash that comes with lymphadenopathy (mononoconemosis of infection) in patients using amoxicillin. Should avoid using drugs if suspected of monomeric hyperlemen.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

The impact of the drug on the ability to drive and operate machinery

The drug does not affect the ability to drive or operate machinery.

Pregnancy and lactation

Pregnant women

Experimental research on the reproductive process of animals (mice) has proved when using oral preparations that do not cause deformities. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months of pregnancy, except for the necessary cases prescribed by a physician.

breastfeeding women

Amoxicillin and sulbactam are excreted into breast milk, cautious when taking the drug for the mother who is breastfeeding. Before using the drug, you should consult your doctor to consider benefits and risks.

Other special subjects (elderly, children, allergies)

No report.

Drug interaction

The drug can cause prolonged bleeding and blood clotting time.

The drug can reduce the effectiveness of oral contraceptives, so warns patients to know this.

Probenecid reduces the elimination of nifedipine renal tubules that increase the absorption of amoxicillin.

Amoxicillin reduces methotrexate secretion, increasing toxicity on the gastrointestinal tract and hematopoietic system.

Simultaneous use with Allopurinol: Increases the risk of skin allergies.

chloramphenicol, macrolid, sulfamid and tetracycline can hinder the bactericidal effect of amoxicillin.

Storage

How should you store amoxicillin medicine?

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

Expiry date: 24 months from the date of manufacture.

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