Bactamox 375 Imexpharm pills treat infections (12 packs)

Dosage form 12 package box
Specifications Amoxicillin, sulbactam
Ingredient Imexpharm Pharmaceutical Joint Stock Company

Ingredient

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Composition informationContent
Amoxicillin250mg
Sulbactam125mg

Uses

Indications

Bactamox 375 drugs are indicated for treatment of infections caused by sensitive bacteria, including:

  • Ear tinema infection: tonsillitis, sinusitis, otitis media.

    • Lower respiratory infections: acute and chronic bronchitis, pneumonia - bronchial.

  • Urinary - genital infections: cystitis, urethritis, pyelonephritis, female genital tract infections.

    • Skin infections and soft tissue: pimples, abscesses, wound infections.

    Bone and joint infections.

  • Dental infections: tooth abscess.
    • Other infections: infections of abortion, blood infections in the postpartum stage, infection in the abdomen.

    Pharmacy

    Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam group with wide bactericidal spectrum for many gram -positive and gram -negative bacteria due to the synthetic inhibition of bacterial cell walls. Amoxicillin is easily destroyed by beta - lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of enerobacteriaceae and haemophilus influenzae).

    Sulbactam is an unfavorable competitive inhibitor with beta - lactamase. The presence of sulbactam in the ingredient increases the effects and expansion of the amoxicillin antibacterial spectrum with the beta - lactamase seminarians.

    antibacterial spectrum:

  • Gram -positive bacteria: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Staphylococcus Epidemidis, Staphylococcus Sprophyticus.
  • Gram -negative bacteria: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella species, Enterobacter, Neisseria Gonorrhoeae, Moraxella CatinhLrhalis, acinetobacter.

    • Anaerobic bacteria: Bacteroides including b. Fragilis, Clostridium, Peptococcus.

    pharmacokinetics

    Amoxicillin is well absorbed after drinking and durable with stomach acid. Food does not affect the absorption of drugs.

    The average peak concentration in serum is achieved after 1-2 hours after drinking. Amoxicillin is quickly distributed into most tissues and fluids in the body except for brain tissue and cerebrospinal fluid, but when the meninges are inflamed, amoxicillin diffuse easily.

    About 20% of the drug is bound to serum protein.

    The semi -canceling time of amoxicillin is about 1 hour, longer in newborns and the elderly, in people with kidney failure, the semi -cancellation time of the drug is about 7-20 hours. About 60% of the oral dosage of amoxicillin eliminates raw form into the urine within 6 - 8 hours. Amoxicillin passes the placenta and is excreted in breast milk in small amounts.

    Sulbactam is well absorbed after drinking. The drug diffuses well into the tissue and body fluid. The peak concentration of SULBactam's serum also achieved the same time as amoxicillin.

    about 40% sulbactam is connected to plasma proteins. Sulbactam is excreted mainly in urine in the form of unchanged (75 - 85%).

    Salbactam's half -life is about 1 hour and lasts longer in people with severe renal failure. The drug is given the placenta and is excreted in breast milk.

    Before taking Bactamox 375 Imexpharm pills treat infections (12 packs)

    How to use

    take medicine before or after meals. Dispersion of drugs in a little water, milk, or fruit juice and drink immediately after mixing.

    Dosage

    Dosage is calculated by amoxicillin.

    Adults, children over 40 kg

    1 pack x 3 times/day.

    Children under 40 kg

  • Mild and medium infections: 20 mg/kg of weight/day, divided into 3 times/day.
  • Severe infections: 40 mg/kg of weight/day, divided into 3 times/day, drink for 5 days.

    • Patients with renal failure

    Creatinine clearance

    Dosage

    30 ml/minute

    No dose adjustment

    10 - 30 ml/minute

    250 - 500 mg/12 hours, depending on the severity of infection

    250 - 500 mg/24 hours, depending on the severity of infection

    Creatinine clearance

    Dosage

    30 ml/minute

    No dose adjustment

    10 - 30 ml/minute

    2/3 of the usual doses, divided into 2 times/day

    1/3 of the usual dose, drink 1 time/day

    Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? The acute reactions occur depending on the hypersensitivity of each individual. In case of overdose, stop taking the drug immediately and use supportive measures, can cause vomiting, gastric lavage if newly overdosed. There is no specific antidote. Amoxicillin and sulbactam can be removed by hemolysis.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that double dose should not be used.

    Side Effects

    When using Bactamox 375, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • diarrhea, itching, foreign rash.
  • Nausea, vomiting, eosinophilia, rash, hepatitis and jaundice, transaminase.
  • Anaphylaxis reactions, Quincke edema, platelet mitigation, leukopenia, hemolytic anemia, fake colitis, Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning, interstitial nephritis.

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Bactamox 375 drugs in the following cases:

  • Hypersensitivity to drug components or antibiotics group penicillin, cephalosporin.

    • History of gastrointestinal diseases, especially ulcerative colitis, Crohn or colitis.

    History of jaundice or liver dysfunction.

    Precautions when using

    Signs and symptoms of cholestasis jaundice are rarely occurring when taking the drug but may be severe. However, those symptoms often recover and will end after 6 weeks of stopping treatment.

    Severe hypersensitivity reactions and sometimes lead to death (anaphylactic form) have been reported in patients using penicillin antibiotics.

    There has been an erythema (diverse) rash that comes with lymphadenopathy (mononoconemosis of infection) in patients using amoxicillin. Should avoid using drugs if suspected of monomeric hyperlemen.

    Taking drugs for prolonged drugs sometimes develops resistant bacteria.

    The ability to drive and operate machinery

    The drug does not affect the ability to drive or operate machinery.

    Pregnancy

    Experimental research on the reproductive process of animals (mice) has proved when using oral preparations that do not cause deformities. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months of pregnancy, except for the necessary cases prescribed by a physician.

    It is necessary to avoid using drugs in pregnant women, especially in the first 3 months of pregnancy, except for the necessary cases prescribed by a physician.

    Breastfeeding period

    amoxicillin and sulbactam are excreted into breast milk, be careful when taking the medication for nursing mothers.

    Drug interaction

  • The drug can cause prolonged bleeding and blood clotting time.
  • The drug can reduce the effectiveness of oral contraceptives, so warns patients with this.

    • Probenecid reduces the elimination of the drug through the renal tubules.

  • nifedipine increases the absorption of amoxicillin.
  • Amoxicillin reduces methotrexate secretion, increasing toxicity on the gastrointestinal tract and hematopoietic system.
  • Simultaneously with alopurinol: Increases the risk of skin allergies.
    • chloramphenicol, macrolid, sulfonamid and tetracyclin can hinder the bactericidal effect of amoxicilin.

    Storage

    temperature below 30ºC, avoid moisture and avoid light.

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    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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