Bactamox 625 Imexpharm Pilly (12 packs)

Dosage form 12 package box
Specifications Amoxicillin, sulbactam
Ingredient Tonsillitis, otitis media, urinary tract infections, skin infections and soft tissue, acute bronchitis, chronic bronchitis, pneumonia

Ingredient

Composition informationContent
Amoxicillin500mg
Sulbactam125mg

Uses

indications

Bactamox 625mg 12 packs are indicated in the following cases:

Treatment of infections caused by sensitive bacteria, including:

  • Ear tinema infection: tonsillitis, sinusitis, otitis media.

    • Lower respiratory infections: acute and chronic bronchitis, pneumonia - bronchial.

    Urinary - genital infections: cystitis, urethritis, pyelonephritis, female genital tract infections.

    Skin infections and soft tissue: pimples, abscesses, wound infections.

    Bone and joint infections.

  • Dental infections: tooth abscess.
    • Other infections: infections of abortion, blood infections in the postpartum stage, infection in the abdomen.

    Pharmacology

    Amoxicillin is a semi-synthetic antibiotic belonging to the Beta-Lactam group with wide bactericidal spectrum for many gram-positive and gram-negative bacteria due to the synthetic inhibition of bacterial cells. Amoxicillin is easily destroyed by beta-lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenzae).

    Sulbactam is an unfavorable competitive inhibitor with beta-lactamase. The presence of sulbactam in the composition increases the effects and expansion of the amoxicillin antibacterial spectrum with the beta-lactamase seminarians.

    Antibacterial Street:

  • Gram -positive bacteria: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Staphylococcus Epidemidis, Staphylococcus Sprophyticus.
  • Gram -negative bacteria: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella species, Enterobacter, Neisseria Gonorrhoeae, Moraxella CatinhLrhalis, acinetobacter.

    • Anaerobic bacteria: Baceroides including B. Fragilis, Clostridium, Peptococcus.

    pharmacokinetic pharmacology

    amoxicillin

  • Absorption: Amoxicillin is well absorbed after drinking and durable with stomach acid. Food does not affect the absorption of drugs. The average peak concentration in serum is achieved after 1-2 hours after drinking.
  • Distribution: Amoxicillin is quickly distributed into most tissues and fluids in the body eliminating brain tissue and cerebrospinal fluid, but when the meninges are inflamed, amoxicillin is diffused easily. About 20% of the drug is connected to serum protein.
  • Metabolism and elimination: The half -life of amoxicillin is about 1 hour, longer in infants and the elderly. In people with kidney failure, the half -life of the drug is about 7-20 hours. About 60% of the oral dosage of amoxicillin eliminates raw form into the urine within 6 - 8 hours. Amoxicillin passes the placenta and is excreted in breast milk in small amounts.

    • Sulbactam

  • Absorption: Sulbactam is well absorbed after drinking. The peak concentration of serum Sulbactam also achieved the same time as amoxicillin.
  • Distribution: Good diffuse drugs into tissues and body fluids. About 40% of sulbactam associated with plasma proteins.
  • Metabolism and elimination: Sulbactam is excreted mainly through urine in the form of unchanged (75 - 85%). The half -life of sulbactam cancellation is about 1 hour and lasts longer in people with severe renal failure. The drug is given the placenta and is excreted in breast milk.

    • Before taking Bactamox 625 Imexpharm Pilly (12 packs)

    How to use

    Take oral use. Take medicine before or after meals. Dispersion of drugs in a little water, milk, or fruit juice and drink immediately after mixing.

    Dosage

    Dosage is calculated by amoxicillin:

    Adults, children over 40 kg: 1 pack x 2-3 times/day.

    Children under 40 kg:

  • Sild and medium infections: 20 mg/kg of weight/day, divided into 3 times/day.
  • Severe infections: 40 mg/kg of weight/day, divided into 3 times/day, drink for 5 days.

    • Adults with kidney failure:

    Creatinine clearance

    Dosage

    30 ml/minute

    No dose adjustment

    10 - 30 ml/minute

    250 - 500 mg/12 hours, depending on the severity of infection

    250 - 500 mg/24 hours, depending on the severity of infection

    Creatinine clearance

    Dosage

    30 ml/minute

    No dose adjustment

    10 - 30 ml/minute

    2/3 of the usual doses, divided into 2 times/day

    1/3 of the usual dose, drink 1 time/day

    Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when overdose? The acute reactions occur depending on the hypersensitivity of each individual. In case of overdose, stop taking the drug immediately and use supportive measures, can cause vomiting, gastric lavage if newly overdosed. There is no specific antidote. Amoxicillin and sulbactam can be removed by hemolysis.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Bactamox 625mg 12 packs, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Digestive: diarrhea.

    • Skin: itching, foreigner.

    Uncommon, 1/1000

  • Digestive: Nausea, vomiting;

    • DA: rash; Blood: Nothing hypernagus; liver: hepatitis, jaundice, multi -stasis, transaminase increase.

    Rare, ADR

  • Hypersensitivity: Anaphylactic reaction, Phuincke edema, Stevens - Johnson syndrome, diverse erythema, bubble dermatitis, epidermal necrosis due to poisoning;
    • Blood: A mitigation of platelets, leukopenia, hemolytic anemia; digestive: fake colitis; kidney: interstitial nephritis.

    Instructions on how to handle ADR

    Notify the doctor with unwanted effects when using the drug.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Bactamox 625mg 12 packs of contraindications in the following cases:

  • Hypersensitivity to drug components or antibiotics group penicillin, cephalosporin.

    • History of gastrointestinal diseases, especially ulcerative colitis, Crohn or colitis.

    History of jaundice or liver dysfunction.

    Be cautious when using

  • Signs and symptoms of cholestasis jaundice are less occurring when taking the drug but may be severe. However, those symptoms often recover and will end after 6 weeks of stopping treatment.

    • Patients with medium and severe renal impairment.

    Severe hypersensitivity reactions can sometimes lead to death (anaphylactic form) that have been reported in patients using penicillin antibiotics.

    There has been a rash (diverse) accompanied by lymphadenopathy (monon cell leukemia) in patients using amoxicillin.

    Should avoid using drugs if suspected of mononucleemia.

  • Take drugs that sometimes develop resistant bacteria.

    • The ability to drive and operate machinery

    The drug does not affect the ability to drive or operate machinery.

    Pregnancy

    Experimental research on the reproductive process of animals (mice) has proved when using oral preparations that do not cause deformities. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months of pregnancy, except for the necessary cases prescribed by a physician.

    The period of breastfeeding

    Amoxicillin and sulbactam are excreted in breast milk, which must be cautious when taking the drug for the mother who is breastfeeding.

    Interactive drug

  • The drug can cause prolonged bleeding and blood clotting time.
  • The drug can reduce the effectiveness of oral contraceptives, so warns patients to know this.

    • Probenecid reduces the elimination of the drug through the renal tubules.

  • nifedipine increases the absorption of amoxicillin.
  • Amoxicillin reduces methotrexate secretion, increasing toxicity on the gastrointestinal tract and hematopoietic system.

    • Simultaneous use with Allopurinol: Increases the risk of skin allergies. chloramphenicol, macrolid, sulfonamid and tetracyclin can hinder the bactericidal effect of amoxicilin.

    Storage

    less than 30 ° C, avoid moisture and light.

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