Bactirid medicine 100mg/5ml Medicraft to treat infections (30ml)

Dosage form Box x 5ml
Specifications Cefixim
Ingredient Urinary infection, respiratory infection

Ingredient

Thành phần cho 5ml

Composition information	Content
Cefixim	100mg

Uses

indications

Bactirid drugs are indicated in the following cases:

Respiratory infections: pharyngitis, otitis media, rhinitis, tonsillitis, acute batches of chronic bronchitis, acute bronchitis.

Pharmacology

Cefixime's bactericidal activity is the result of the inhibition of cell wall synthesis. Cefixime stabilizes with beta - lactamase and as a result, many bacteria are resistant to penicillin and some cephalosporins due to the presence of beta - lactamase may be sensitive to cefixime.

The clinical effect has been shown in the common bacterial infections such as Streptococcus Pneumoniae, Streptococcus Pyogenes, Escheriachia Coli, Salmonella Typhi, Proteus Mirabilis, Klebsiella spp, Haemopilus Influenzae (Beta - Lactamase positive and negative) Catnrhalis (Beta - Lactamase positive and negative), and Enerobacter spp.

Cefixime is also very highly active, both in vitro and clinical infections are caused by anaerobic bacteria such as peptostreptococcus spp., Lactobacillus spp., and Veillonella spp. Most Enterococcus lines (Streptococcus Faecalis, Streptococcus group D), Staphylococcus (including positive and negative coagulase lines and anti -methicillin lines), Pseudomonas, Bacteroides Fragilis, Listeria Monocytogenes and Clostridia are resistant to CEFIXIME.

Mechanism of action

Cefixime is a 3rd generation cephalosporin antibiotic, used by oral. The drug has a bactericidal effect.

Cefixime's bactericidal mechanism is similar to other cephalosporins: attached to target proteins (penicillin -mounted proteins) that inhibit mucopeptide synthesis in bacterial cell walls. The bacterial resistance mechanism of bacteria is to reduce Cefixime's affinity for target protein or reduce the permeability of bacterial cell membranes for drugs.

Cefixim has high durability with the hydrolysis of beta - lactamase encoded by the gene located on plasmid and chromosom. Sustainability with beta - lactamase of Cefixime is higher than Cefaclor, Cefoxitin, Cefuroxime, Cephalexin, Cephradin.

pharmacokinetics

only about 40-50% of the dose is absorbed through the gastrointestinal tract. Cefixime absorption is not significantly changed when food. Cefixime solution is better absorbed than tablets. The peak concentration of plasma is reached 2 - 3 mcg/ml with oral dose of 200 mg after 2 hours and 3.7 - 4.6 mcg/ml with oral dose of 400 mg after 6 hours.

In people with kidney failure, half -life of plasma lasts for 3-4 hours. About 65% Cefixime has a protein cohesion. The distribution of cefixime in tissues, solutions of the body is limited. Cefixime passes through the placenta and is highly concentrated in bile and urine.

The drug is eliminated through the kidneys and half -life is 0.8 - 2 hours. About 20% of the dose (equivalent to about 50% of the absorption dose) is eliminated in the form of unchanged urine within 24 hours. About 60% of the dose is not eliminated through the mechanism of renal operation.

Before taking Bactirid medicine 100mg/5ml Medicraft to treat infections (30ml)

How to use

Take oral use.

Add 10 ml of cooled boiled water to the dry powder mixture in the bottle and shake the dough, then add 10 ml of water and shake to form 30 ml of the mixture.

The mixture after mixing is only used within 1 week of storage in a cool dry place, temperatures below 30 ° C, avoiding light. Shake the jar of the chaos before use.

Dosage

Adults

The recommended dose of Cefixime is 400 mg per day (corresponding to 20 ml of mixed mixture). This dose can be used once or can be divided into 2 times.

For long -term treatment, it is recommended to use a single -dose of 400 mg (corresponding to 20 ml of mixed mixture).

Children weigh over 50 kg or children over 12 years old

Use the dose as adults.

Children from 6 months to 12 years of age can be important

Use the dose of 4 mg Cefixime in chaos/kg body/1 time, 2 times a day or 8 mg Cefixime in the form of a chaos/kg body weight/1 time daily.

In the treatment of s.pyogenes infections, the treatment time with Cefixime should last for at least 10 days.

Patients with renal function

Cefixime can be used for patients with renal function.

The normal dose and dosage mode can be applied to patients with clearance> = 60 ml/min.

Patients with clearance between 21 - 60 ml/minute or patient being hemorrhage may use about 75% of the standard dose.

Patients with clearance of

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Adultery effects are seen at a dose of up to 2 g of cefixime in ordinary people not different from the figures found in patients treated with recommended dose.

Gastrointestinal lavage may be started when overdose. There is currently no specific antidote. Differences do not significantly eliminate the amount of cefixime.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Bactirid, you may experience unwanted effects (ADR).

cefixime generally tolerated well. Most of the adverse effects observed in clinical studies are light and self -limited.

Gastrointestinal disorders

The most common adverse effects with Cefixime are diarrhea and stool disorders. In some cases, the average to severe diarrhea has been reported, it must be discontinued if the diarrhea occurs seriously. The extra effects of the gastrointestinal tract occur such as nausea, abdominal pain, digestive disorders, vomiting and constipation. Fake colitis has been reported.

Central nervous system

headache and dizziness.

Hypersensitivity reaction

allergies include emphasis, itching, urticaria, fever and joint pain due to the observed drug. These reactions often decrease during treatment.

Hematology and clinical chemistry

Ophthalmic reduction, leukopenia and eosinophilia have been reported. These reactions do not usually occur and recover themselves. The slight changes of liver function tests and renal function have been observed. Occasionally increase amylase in the serum has been reported.

Other adultery effects

The reactions may be different including genital itching and vaginitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Bactirid drugs contraindicated in the following cases:

Patients with a history of hypersensitivity to any component of other drugs and antibiotics of other cephalosporin groups.

Do not use for children under 6 months old, pregnant or lactating women.

Be cautious when using

cefixime must be careful when used in patients with severe renal failure.

Cefixime must be careful when prescribing in patients with a history of gastrointestinal disease, especially colitis.

cefixime must be cautious when used in people who know hypersensitivity to other cephalosporin drugs. Be careful when used in patients sensitive to penicillin, there are some evidence of cross allergy between penicillin and cephalosporin. If an allergic reaction occurs with Cefixime, the drug should be discontinued and the patient should be treated with appropriate drugs if necessary. Treatment with broad -spectrum antibiotics, including cefixime, changes the common bacteria in the colon and may allow the growth of Clostridium.

Studies show that toxins produced by Clostridium difficile are the main cause of severe diarrhea due to antibiotics including fake colitis.

Safety and effectiveness of Cefixime has not been established in children under 6 months old.

There has been no research to show the safety of the drug for pregnant and lactating women. So do not use drugs for pregnant and lactating women.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

There has been no research to show the safety of the drug for pregnant and lactating women. So do not use drugs for pregnant women.

The period of breastfeeding

It is unclear whether cefixime will excrete in milk. Consider temporarily stop feeding milk during the time the mother took medicine.

drug interaction

so far, no significant interaction has been reported. The glucose test in urine may occur fake positive with Benedict or Fehling solutions or with copper sulphate test tables, but not with tests based on glucose oxidase reactions. Coombs test directly positively positive during treatment with cephalosporin antibiotics, so it should be noted that the positive Coombs test may be due to the drug.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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