Bambec 10mg drug Astrazeneca treats bronchial asthma, bronchospasm (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bambuterol
Ingredient Astra

Ingredient

Composition information	Content
Bambuterol	10mg

Uses

Indications

Treatment of bronchial asthma, bronchospasm and/or obstruction of the recovery gas path.

Pharmacokology

Bambec contains bambuterol is the precursor of terbutalin, the owner of the velocate on the beta receptor, selective stimulation on beta - 2, thus relaxing bronchial muscles, inhibiting the release of endogenous spasms, inhibiting endomemotic reactions caused by endogenous intermediaries and increasing the waste of the hair and the waste of the hair and the waste of the hair, the elaborate of the expansion of the hair and the waste of the hair. mucus.

pharmacokinetic

absorption

About 20% of the dose of Bambuterol oral oral absorption. The absorption of drugs is not affected when used simultaneously with food. The maximum concentration in the plasma of terbutalin, the metabolites are active, achieved within 2 - 6 hours. The effect time lasts at least 24 hours. Achieving the status of 4 - 5 days of treatment.

Distribution

No data.

Metabolism

About 90% of bambuterol is slowly metabolized by hydrolysis reaction (by enzyme cholinesterase in plasma) and oxidizing into active terbutalin. About 1/3 of the absorption bambuterol dose is metabolized in the intestinal wall and liver, mainly into intermediate metabolic forms. In adults, about 10% of bambuterol drink into transforming into terbutalin.

Elimination

Bambuterol's half -life after drinking about 13 hours. The half -life of the active metabolites is about 21 hours.

Bambuterol and its metabolic forms including terbutalin are excreted mainly through the kidneys, so patients with renal impairment (creatinine clearance

Before taking Bambec 10mg drug Astrazeneca treats bronchial asthma, bronchospasm (3 blisters x 10 tablets)

How to use

oral oral medications right before going to bed.

Dosage

Dosage 1 time/day. Need to adjust the dose suitable for individuals. Patients must use optimal anti -inflammatory therapy (such as inhaled corticosteroids, Leukotrien receptor resistant drugs) when using bambec for maintenance treatment in asthma.

Adults

Starting dose of 10mg - 20mg. Can increase the dose from 10mg to 20mg after 1-2 weeks, depending on the clinical effect.

In patients who have previously tolerated the beta -2 agonized owners, the starting dose as well as the maintenance dose is 20mg.

Elderly

No dose adjustment.

Patients with liver dysfunction

It is not recommended for patients with liver dysfunction because it is not predicted to convert into terbutalin.

Patients with average to severe kidney function (GFR

Recommended the use of bambec starts with half the dose in adults.

Children

Do not use bambec for children until there are all clinical data.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Hypotension sometimes occurs due to terbutalin overdose. Subclinical signs: hyperglycemia, blood lactic acid contamination sometimes occurs. High doses of Beta-2 motorcycle owner can cause hypokalemia due to potassium redistribution.

Bambec overdose can significantly inhibit plasma cholinininusterase for a few days.

Overdose treatment:

often do not need treatment. In case of severe overdose, the following methods should be taken:

Gastric lavage, activated carbon. Assess the balance of acidic alkaline, blood sugar and electrolytes. Monitor the frequency, heart rate and blood pressure. The appropriate detoxifying substance when overdose Bambec is a selective beta receptor inhibitor, but the beta receptor inhibitors need to be used cautiously in patients with a history of bronchospasm. If the decrease in peripheral blood vessels through beta-2 intermediaries contributes significantly to reducing blood pressure, the plasma volume is required.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Bambec may experience some of the following side effects:

Very common, ADR> 1/10:

Nervous system: muscle tremor, headache.

Mental: behavioral disorders such as restlessness, sleep disorders.

Cardiovascular: Brushing the chest.

Mental: behavioral disorders such as anxiety.

Cardiovascular: Local myocardial ischemia Blood, hyperglycemia.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Bambec drugs contraindicated in the following cases:

Hypersensitivity to Terbutalin or any other ingredients of the drug.

Caution when used

In patients with cirrhosis and patients with severe liver function damage due to other causes, daily doses must be adjusted appropriately for each individual, need to assess the ability to convert Bambuterol into terbutalin in patients with impaired or not. Therefore, based on the viewpoint of practice, directly using active metabolites, Terbutalin (BRICANYL), is more appropriate in these patients.

Use bambec cautious in patients with toxic armor.

rarely occur local myocardial ischemia related to beta -driven drug owners. Patients with severe heart disease (ischemia, arrhythmia or severe heart failure) are taking Bambec, should notify the doctor if they feel angina or symptoms of heart disease progresses. Pay attention to the assessment of symptoms such as shortness of breath and angina because it may be due to respiratory or cardiovascular disease.

Although Bambec does not use the treatment of premature birth, it is also important to note that bambuterol converts to terbutalin and should not use terbutalin such as anti -spasms in patients with a history of ischemia or patients at risk of ischemia.

Due to the effect of increasing the blood sugar of beta-2 agar, it is necessary to better control blood sugar in diabetics at the beginning of treatment.

Hyperbathing hypokalemia may occur when treated with beta-2 agar. It is necessary to be especially careful in acute severe severe asthma attacks due to increased risk of hypokalemia when reducing blood oxygen. The impact of reducing potassium can occur during coordination treatment. Need to monitor serum potassium concentration in these cases.

Hypotension can increase the tendency of arrhythmia. Especially cautious in patients treated with digitalis glycosides due to hypokalemia also increases the risk of Digitalis poisoning.

Patients with prolonged asthma requirements for maintenance treatment with beta-2 agreement should also be optimal anti-inflammatory treatment such as inhaled corticosteroids, Leukotriene receptor anti-receptor drugs. These patients should be consulted to continue treating with anti -inflammatory after using Bambec even until symptoms have decreased. If the symptoms still exist or need to increase the dose of treatment with the Beta-2 owner, this shows that there is a worse progression of the background disease and should be re-evaluated.

Do not start or increase the dose of bambec when treating asthma attacks.

Bambec tablets contain lactose. Patients should not use drugs if there are rare genetic problems: galactose intolerance, complete lactase enzyme deficiency or glucose-galactose.

Precautions when treating patients with narrow angle glaucoma.

The ability to drive and operate machinery

bambec does not affect the ability to drive and operate the machine.

Pregnancy

although it has not seen a teratogenic effect in animals after using bambuterol, need to be cautious in the first 3 months of pregnancy. Precautions when using Beta -Beta -2 -year -old drinking drugs in the final stage of pregnancy due to anti -spasms. Hypoglycemic hypoglycemia is recorded in premature babies whose mothers are treated with beta -2.

The period of breastfeeding

It is not known whether bambuterol or intermediate metabolic forms will go through breast milk or not. Terbutalin passes through breast milk but does not see any effect on the emulsion at the dose of treatment. Conducting breastfeeding or stopping treatment with bambec is decided based on the benefits of breastfeeding and treating the mother.

Drug interaction

bambuterol extends the muscle stretch effects of Suxamethonium (Succinylcholin). This impact is due to cholinesterase in plasma, the inactivated enzyme of Suxamethonium, partially inhibited by Bambuterol. The inhibition depends on the dosage and can recover completely after stopping treatment with Bambuterol. This interaction should also be considered with other muscle relaxants metabolized by CholininineseTerase.

Beta receptor inhibitors (including eye drops), especially non -selective inhibitors, can inhibit partial or complete effects of beta receptor stimulants.

Avoid using Halothan anesthesia when treated with beta-2 agent due to an increased risk of arrhythmia. Precautions when using other halogen anesthesia with Beta-2.

Due to the impact of hypokalemia of beta-2 agonists, caution when using the serum potassium waste is known to increase the risk of reducing potassium, such as diuretics, methyl xanthin and corticosteroids.

Use bambec caution in patients being treated with other sympathetic nerve stimulants. Theoretically, the concentration of bambuterol is reduced by quinidine due to quinidine inhibits cholinesterase even at treatment dose.

Simultaneously used with salbutamol and ipratropium in asthma treatment (aerosol spray) can cause narrow angle glaucoma. Terbutalin seems to interact with ipratropium similar to salbutamol when taking the drug with aerosol sprayer. This combination is not recommended for patients who are likely to suffer.

Storage

Store at a temperature not exceeding 30 ° C.

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