Bamifen medicine 10mg Remedica reduces muscle spasms (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Baclofen
Ingredient Remedica

Ingredient

Composition information	Content
Baclofen	10mg

Uses

Indications

Bamifen is indicated to reduce muscle spasms in disorders such as scattered sclerosis, other spinal lesions such as spinal cord, spinal cord disease, mental neuron disease, marrow inflammation, partial spinal trauma. Bamifen is also indicated for adults and children to reduce muscle spasticity due to cerebrovascular damage, cerebral paralysis, encephalitis, head injury. Patient choice is a very important stage in starting bamifen treatment, the drug seems to be most effective when used for patients with muscle stiffness due to mobility or physical therapy patients. Do not recommend treatment until there is a spasticity.

Pharmacokology

Bamifen is an anti -spasticity acting on the spine, the derivative of gamma - Aminobutyric Acid (GABA), Bamifen's chemical structure formula is not related to other anti -spasms.

Bamifen reduces SINAP and Sinap single reflection transmission, may be due to GABA-receiver stimulation, which leads to the inhibition of the release of amino acids that stimulate the stimulating effect: glutamate and aspartate. Neurotrotomy is not affected by Bamifen.

The main benefit of Bamifen is the ability to relieve pain due to folding muscle spasms and spontaneous vibration reduction thus increases patient movement ability, increases the initiative and recovery ability for patients.

Bamifen also has a resistance effect. Often improved better and sedative effects less than central nervous effects. Baclofen stimulates the stomach to excrete acid.

pharmacokinetic

absorption

Bamifen absorbs quickly and completely through the gastrointestinal tract. After taking 1 dose (10 - 30mg) of the peak concentration in plasma recorded after 0.5 to 1.5 hours and the area under the curve is proportional to the dose.

Distribution

The distribution of Baclofen is 0.7L/kg and the protein mounting rate is about 30%. In cerebrospinal fluid, the concentration of substance is about 8.5 times lower in plasma.

Metabolism

Baclofen is metabolized at a small percentage. Eliminate amino to form the main metabolites- (p-chlorophenyl)- 4-hydroxybutyric acid, which is no longer active.

Elimination

Semi -selling time in baclofen's plasma averages 3 to 4 hours. Plasma protein ratio is about 30%.

Baclofen is eliminated mainly in the form of unprovered. Within 72 hours, about 75% of the dose was eliminated through the kidney, about 5% have been metabolized.

Before taking Bamifen medicine 10mg Remedica reduces muscle spasms (6 blisters x 10 tablets)

How to use

as directed by the doctor

Dosage

Adults

Should increase the dose slowly as follows, but should be adjusted to suit each patient.

5mg x 3 times/day for 3 days.

10mg x 3 times/day for 3 days.

15mg x 3 times/day for 3 days.

20mg x 3 times/day for 3 days.

With a dose of up to 60mg/day, usually controlled symptoms, but careful evaluation is necessary for each patient. The dose may be slowly increased if necessary but do not recommend a maximum dose per day over 100mg unless the patient is being treated in the hospital under the careful supervision of the doctor.

In some cases, divide the drug into smaller doses when taking the drug at the distance between large doses. Some patients use Bamifen only in the evening to reduce pain due to folding muscle spasms. Similarly, taking 1 dose about 1 hour before doing a specific task such as washing, wearing clothes, shaving, physiotherapy often makes the patient easier to exercise. When the maximum recommended dose has been reached, if the treatment effect is not seen within 6 weeks, it is advisable to consider whether or not to use Bamifen anymore.

Elderly

Should start treatment with small doses, dosage and then gradually adjusted based on the response of patients when carefully monitored.

Children

Should use a dose of 0.75 - 2mg/kg body weight. However, children greater than 10 years old, a maximum dose of a day may be 2.5mg/kg body weight. Often starting with 2.5mg dose divided into 4 times a day. The dose should be carefully increased, the distance between the dose increasing is 3 days until you find the right dose for each patient. The daily recommended dose for maintenance treatment is as follows:

Children from the age:

12 months to 2 years: 10 - 20mg.

2 years - 6 years: 20 - 30mg.

recommendations for low doses, for example, about 5mg/day.

Patients in brain spasticity

Unwanted effects often occur in these patients. Therefore, the dose should be carefully considered and should have appropriate monitoring.

What to do when overdose?

Symptoms of an overdose: Drop drowsiness, mixed, reduced reflexes, shortness of breath, hypotension, disorders of language, reduced muscle tone, coma ... may also appear depression, slow heart rate, temperature drop, nausea, vomiting, diarrhea, increase LDH, SGOT and AP.

Treatment: There is no specific antidote to treat an overdose of Baclofen. Can use general support measures such as gastric lavage, active carbon and use solutions as well as diuretic.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Like all other drugs, Bamifen can cause unwanted effects.

The most unwanted effects are: Central neurological disorders (drowsiness, falling asleep, nausea, respiratory inhibition, superficial, fatigue, exhaustion, confusion, dizziness, headache, insomnia, pleasure, depression, muscle weakness, dysplasia, tremor, depression, nightmares, muscle pain, eye -catching eye, omnipomible, omniscient, ferococent disorders). secretion, visual disorders, taste disorders), disorders on the gastrointestinal tract (nausea, mild digestive disorders of constipation, diarrhea and vomiting, abdominal pain), disorders on the cardiovascular system (lowering blood pressure, reducing cardiovascular function), disorders on urinary genital systems (regular urination, bed beams, difficulty urinating, urinary urination, powerlessness)

Some patients increased spasms, may also experience unwanted muscle tone and often decreased when adjusting the dose.

Need to notify the doctor immediately if there is any unwanted effect mentioned above.

Warnings

Contraindicated

Bamifen drugs are contraindicated in the following cases: hypersensitivity to baclofen, peptic ulcer.

Be cautious when taking the drug

should be cautious when taking Bamifen for patients with blood vessel damage, epilepsy, mental disorders, digestive ulcers, and the elderly. Should start increasing the dose slowly. Unless there is an unwanted effect, when stopping treatment, it should be stopped by reducing the dose slowly for about 1 to 2 weeks before stopping. In the composition of this product contains lactose, tell your doctor before you use this medication if your doctor said you did not tolerate some sugar.

The ability to drive and operate machinery

Bamifen can cause sleep, so it can affect the ability to drive and operate machinery. Responsible for using alcoholic food/drink.

Pregnancy

do not recommend using Bamifen during pregnancy. Advise a doctor or pharmacist before taking any drug.

breastfeeding period

The amount of baclofen excreted in milk is too small to be dangerous. Advise a doctor or pharmacist before taking any medicine.

Drug interaction

should not be used simultaneously with drugs interacting with Baclofen. However, some drugs interact with Baclofen can still be used simultaneously but need to be especially careful. In this case, your doctor may change the dose or some other carefully if needed. It is important to notify your doctor or pharmacist if you are taking other drugs, especially the following drugs: 3 -round antidepressants or capillary inhibitors, central neurological inhibitors, ibuprofen, lowering blood pressure drugs, diuretics, anti -diabetes drugs, carbidopa/levodopa, alcohol.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

Expiry date: 60 months from the date of manufacture.

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