Baribit bio-labs topical treatment for skin diseases (15g)

Dosage form Tube x 15g
Specifications Betamethasone, salicylic acid
Ingredient Eczema, psoriasis, atopic dermatitis, oily dermatitis, contact dermatitis

Ingredient

Thành phần cho 1g

Composition information	Content
Betamethasone	0.064%
Salicylic acid	3%

Uses

Indications

Baribit medicine is indicated in the following cases:

Betamethasone has the effect of skin diseases: Liken's local infection, hypertrophy (Lichen), psoriasis rash, keloid scars, Luput discs, diverse erythema (Stevens-Johnson syndrome), peeling dermatitis, contact dermatitis. Salicylic acid when used on the spot works to soften and destroy the horny layer. Therefore, the baribit is indicated for skin diseases that need to be treated with betamethasone on dry, horny skin.

Pharmacokology

Betamethason is a synthetic corticosteroid. When used on the skin, the drug has anti -inflammatory effects due to the synthesis of chemical intermediates that cause inflammation and inhibitors release chemical mediators that cause allergic reactions such as histamine, bradykinin, serotonin ...

Salicylic acid works to strongly peel off the horny layer and mild antiseptic when applied on the skin. At low concentrations, the drug has the effect of shaping the horny layer (adjusting the abnormalities of the horn process); At high concentrations (> 1%), the drug works to peel off the horny layer. Salicylic acid softens and destroys the horny layer by endogenous hydration, which can be due to reducing pH, causing the epithelial layer to swell, then peel off. When applying too much, the drug can cause normal skin necrosis. At high concentrations (eg 20%), salicylic acid has a skin corrosion effect.

Moist medium is necessary for salicylic acid to light and peel the epidermal tissue.

The drug has a weak anti -fungal effect, thanks to the horny layer to prevent the fungus from developing and help the antifungal drugs absorb into the skin. When coordinated, salicylic acid and sulfur have the effect of peeling force.

pharmacokinetics

betamethason: The drug is easily absorbed when used on the spot. When applied, especially if the skin is torn or when the skin is torn or when the rectum, there may be a amount of betamethasone that is absorbed enough for the whole body effect. Betamethason quickly distributed into all tissues in the body.

The drug through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethason is widely linked to plasma proteins, mainly with globulin and the albumin is less. Synthetic corticosteroids include betamethason, less spacious links with protein than hydrocortison. Their half -life also tends to be longer.

betamethason is a prolonged glucocorticoid. The corticosteroids are metabolized mainly in the liver but also in the kidneys and the issue into the urine. The metabolism of synthetic corticosteroids, including betamethasone, is slower and their protein bonding is lower, which can explain more powerful than natural corticosteroids.

Salicylic acid is easily absorbed through the skin and slowly excreted through the urine, so there have been cases of salicylate poisoning after using too much salicylic acid on a large scale of the body.

Before taking Baribit bio-labs topical treatment for skin diseases (15g)

How to use

The drug is used on the skin.

Dosage

Adults

Apply medicine into thin layer on the sick area 1-2 times daily.

Should take the drug up to 2 weeks. The maximum dose for each week does not exceed 60g.

Children

Children should not take medicine for more than 5 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Effects due to increased corticosteroids do not appear early unless high doses are continuous.

Symptoms

Systemic effects due to corticosteroid overdose include: Sodium and water holding effects, increasing appetite, mobilizing calcium and phosphorus accompanied by osteoporosis, loss of nitrogen, hyperglycemia, reducing the effect of tissue regeneration, increasing sensory with bacterial infections, adrenal insect activity, mental and mental disorders, muscle weakness.

Treatment

In case of an overdose, need to monitor serum and urine.

Pay special attention to sodium and potassium balance. In the case of chronic poisoning, stop the drug slowly. Treatment of electrolyte imbalance if needed.

When taking salicylic acid, poisoning symptoms often manifest vary depending on the person such as deep breathing, fast, tinnitus, deafness, vasodilation, sweating. Gastric lavage and plasma pH must be monitored, plasma salicylate concentrations and electrolytes. Mandatory urine can be alkalinized to increase the urinary tract, if the concentration of alicylate in plasma is over 500mg/liter in adults or 300mg/liter in children.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Prolonged treatment with high activity corticosteroids can cause local atrophy such as skin cracks, thin skin, surface blood vessels, especially when treated with sealed, or on skin folds.

As well as local -acting corticosteroids, when used in a large amount of prolonged, or treated on a large skin area, the drug can be absorbed in the body with sufficient amounts to cause signs of adrenal enhancement. This effect is more likely to occur in children with children, children, and in the treatment of closed drugs. In children with children, diapers can work as when the skin is covered with medicine.

In rare cases, treatment (or stop treatment, psoriasis with corticosteroids is thought to have initially developed pustules of the disease.

Long -term use of salicylic acid can be poisoned by salicylate (with symptoms: confusion, dizziness, severe or continuous headache, rapid breathing, vibration or chiffon sound in the ear continuously). Treatment of warts with high concentrations can cause skin, and thus make warts easily spread.

Common, ADR> 1/100

Light skin irritation, burning sensation.

Uncommon, 1/1000

Skin irritation, average to heavy. Ulcers or skin corrosion, especially when using preparations with high concentration salicylic acid.

Instructions on how to handle ADR

If you have an eye on the eye, mucosa, you must wash immediately with clean water for 15 minutes. Wash your hands immediately after applying the medication, unless you have to apply it in your hands.

Normally, the baribit is well tolerated, but if there are signs of hypersensitivity, it is advisable to stop using

Warnings

Contraindicated

Too sensitive to any ingredients of the drug.

Patients with chronic dermatitis, acne, dermatitis around the mouth, itching around the anus and genitals, viral skin infections.

The drug is not indicated in the treatment of skin damage caused by fungal infections.

Precautions when taking drugs

Do not bandage the wound after applying the drug because it can increase the absorption of drug steroids continuously on a wide skin that can be toxicity on the spot or the whole body, especially for infants and young children, even if the area is not covered with medication. In case of use for children, do not take more than 5 days.

Located corticosteroids to treat psoriasis can cause risks such as recurrence, oily pills, puu psoriasis, and the ability to poison local or body toxicity due to damaged skin barrier function. When using corticosteroids to treat psoriasis, careful monitoring of patients.

Salicylic acid preparations are only used outside. Avoid applying to the mouth, eyes, mucosa.

Protect the surrounding skin, avoid chapped skin, do not apply the medicine on the face, the anus, or on a large scale. May cause a whole body effect when used too much. Although Salicylate is used in place is much less absorbed than drinking, there may still be side effects. To limit the absorption of salicylic acid, not long -term, high concentration, widespread or applied on inflamed or chapped skin. It is also necessary to be cautious when applied on peripheral peripheral and diabetic impaired people.

If the skin is too dry or has skin irritation, patients should stop taking the drug.

Be cautious when taking medicine for young children.

The ability to drive and operate machinery

No data.

Pregnancy and lactation

Pregnancy

There is no data on the effects of baribits on pregnant women. However, pregnant women should not apply drugs in large quantities or for a long time. Please consult your doctor to consider benefits and risks.

Breastfeeding period

During breastfeeding if it is really necessary, consult a doctor and pharmacist to consider the benefits and risks.

Drug interaction

The ability to interact between topical medication and other drugs rarely occurs under common conditions.

To avoid drug interactions, it is best to write a list of drugs that are used (including prescription, non -prescription, herbal, functional foods) and for doctors or pharmacists. To ensure safety when taking the drug, you do not arbitrarily take the drug, stop or change the dosage of the drug without the permission of a doctor.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

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